Plasma calcium and parathyroid hormone responses to EDTA infusion in the cow

Abstract

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Experimental Hypocalcemia Induced by Hemodialysis in Goats.

“…This may be caused by phosphorus loss in colostrum, inadequate phosphorus intake around parturition, inadequate phosphorus mobilization from bone, and/or phosphorus diuresis caused by the high blood concentrations of parathyroid hormone (PTH) due to hypocalcemia [17]. In the present study, the plasma P concentrations significantly decreased followed by a reduction in the Ca concentrations during Ca-free HD, which was the same result as in previous studies on experimental hypocalcemia induced by Na 2 EDTA infusion in cows and sheep [3,9,18,19,22]. In experimental hypocalcemia, it is suggested that the hypophosphatemia is due to PTH action.…”

“…The clinical signs found in the goats on Ca-free HD were ataxia (i. e., staggering and repeated reeling and falling, associated with muscle tremor), dullness, shivering, ruminal stasis and decreased heart sound intensity. These clinical signs seemed to resemble those in milk fever cows and experimental hypocalcemic ruminants previously reported [8,12,13,17,18,21,22].…”

“…The clinical signs observed during hemodialysis were mobility, demeanor, shivering, ruminal motility and heart sound quality by auscultation. Blood There are numerous reports dealing with an experimentally induced hypocalcemia in ruminants as a model for studies of the pathophysiology and prophylaxis of milk fever (parturient paresis, parturient hypocalcemia) [3,8,9,12,13,18,19,22]. Most of the reports have described an intravenous infusion of disodium ethylenediaminetetraacetic acid (Na 2 EDTA) solution to induce experimental hypocalcemia.…”

“…Most of the reports have described an intravenous infusion of disodium ethylenediaminetetraacetic acid (Na 2 EDTA) solution to induce experimental hypocalcemia. Some of the authors have reported that accidental death sometimes occurs in the experimental animals as a result of the Na 2 EDTA infusion [8,22]. The cause of death remains unclear, but they have assumed that death occurs due to the side effects of the Na 2 EDTA infusion [8,22].…”

“…Some of the authors have reported that accidental death sometimes occurs in the experimental animals as a result of the Na 2 EDTA infusion [8,22]. The cause of death remains unclear, but they have assumed that death occurs due to the side effects of the Na 2 EDTA infusion [8,22]. Nephrotoxicity and hepatoxicity are known to be side effects of the Na 2 EDTA infusion [6,7,10].…”