Plasma Calcium Homeostasis in the Guinea Pig during the Perinatal Period

Durand, D. Vital; Dalle, M; Barlet, J.P.

doi:10.1159/000241585

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…Plasma magnesium deficiency can cause low birth weights in animals 22 and the double knockouts had the lowest plasma magnesium concentrations and smallest birth weights. In rodents, plasma phosphate concentrations decrease during the 12 h following birth and then increase 23, 24, consistent with our wild‐type mouse results between E17 and P1. However, the APP and APLP2 single knockouts had no significant differences between E17 and P1, indicating an abnormal phenotype.…”

Section: Discussionmentioning

confidence: 99%

Photophysical Properties of BODIPY‐Derived Hydroxyaryl Fluorescent pH Probes in Solution

et al. 2005

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The photophysical properties of five fluorescent pH probes derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene with phenolic or naphtholic subunits at position 8 and with substituents having different electron driving forces at positions 3 and 5 have been investigated in several organic solvents, by means of absorption, steady-state, and time-resolved fluorimetry. For each compound, the fluorescence quantum yield and lifetime are lower in solvents with higher polarity, owing to an increase in the rate of nonradiative deactivation. The rate constants for radiative deactivation, k(f), are nearly constant for all dyes in all solvents studied [k(f)=(1.7+/-0.2)x10(8) s(-1)]. In aqueous solution, these probes undergo a reversible protonation-deprotonation in the near-neutral to basic pH range, producing intensity increases with lower pH. The pK(a) values of the indicators are between 7.5 and 9.3, depending on the substitution pattern on positions 3, 5, and 8. The difference between the absorption and excitation spectra as a function of pH is indicative of the presence of two species in aqueous solution: the phenol- or naphthol-based indicator and its conjugate base.

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Section: Discussionmentioning

confidence: 99%

Photophysical Properties of BODIPY‐Derived Hydroxyaryl Fluorescent pH Probes in Solution

et al. 2005

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“…Care, Ross, Pickard, Weatherley, Garel, Manning, Allgrove, Papapoulos & O'Riordan, 1982). The transient plasma hypocalcaemia seen at birth in the rat also occurs in other mammals, such as, for example, the guinea-pig (Durand, Dalle & Barlet, 1982). This phenomenon is probably due to a delay between birth with the cessation of placental calcium transport, and the first uptake of milk calcium, during which time there will be a loss of plasma calcium due to skeletal deposition.…”

Section: Control Plasma Calciummentioning

confidence: 97%

Brain fluid calcium concentration and response to acute hypercalcaemia during development in the rat.

Jones

Keep

1988

The Journal of Physiology

144

106

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Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

Needham

Wlodek

Ciccotosto

et al. 2008

The Journal of Pathology

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The amyloid precursor protein (APP), the source of the neurotoxic amyloid beta (A beta) peptide involved in Alzheimer's disease (AD), belongs to a conserved family of related proteins. In mammals, the APP family contains amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2). Whilst a number of activities have been attributed to the APP family, an overall function has not been definitively established. While ablating either the APP or APLP2 gene in mice produces minimal phenotypic change, the combined knockout of these genes in mice causes postnatal mortality. Postnatal survival therefore requires a shared but unknown function of APP and APLP2. To investigate the biochemical basis for the postnatal lethality, plasma was analysed from double knockout mice (APP-/- APLP2-/-) 2 days before birth, at gestational day E17, and from mice at 12-16 h after birth. The postnatal double knockouts had 66% lower plasma glucose levels than their wild-type controls and 50% lower than their single knockout counterparts. Interestingly, the postnatal double knockouts displayed hyperinsulinaemia, as shown by inappropriate plasma insulin levels, given their degree of hypoglycaemia. The single knockout mice also showed hyperinsulinaemia and had 31% lower plasma glucose than the wild-types. While the double knockouts did not survive more than 24 h after birth, the single knockouts reached adulthood and their hypoglycaemia continued. Therefore, APP and APLP2 expression modulates plasma insulin and glucose concentrations. Plasma calcium, magnesium and phosphate were also significantly reduced in the double knockouts compared to the wild-types, and they showed distinctive growth restriction, suggesting the involvement of a metabolic impairment. These results link the expression of the APP and APLP2 genes with glucose homeostasis and growth and therefore identify a novel function for the APP family.

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Plasma Calcium Homeostasis in the Guinea Pig during the Perinatal Period

Cited by 8 publications

References 14 publications

Photophysical Properties of BODIPY‐Derived Hydroxyaryl Fluorescent pH Probes in Solution

Photophysical Properties of BODIPY‐Derived Hydroxyaryl Fluorescent pH Probes in Solution

Brain fluid calcium concentration and response to acute hypercalcaemia during development in the rat.

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

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