Plasma cell granulomas of the lung

Abstract

Plasma cell granuloma of the lung, a designation that we consider preferable to “inflammatory pseudotumor,” represents localized proliferations predominantly of mature plasma cells, with Russell bodies, reticuloendothelial cells, and intermediate forms, supported by a stroma of granulation tissue. Other cellular elements, including lymphocytes and large mononuclear cells, may coexist with the plasma cells. The latter may have a large content of cytoplasmic fat, hence the term “xanthoma” or “fibroxanthoma” applied by some. The stroma may contain interlacing or whorled masses of fibroblasts, and may be focally ossified or calcified. It is often hyalinized with an appearance similar to that of paramyloid. These lesions are usually asymptomatic, and are most commonly detected in routine chest films as circumscribed “coin” lesions, or large masses. They may be static or increase slowly in size. In a minority, they are sessile or polypoid intrabronchial masses. More than two thirds of the patients are less than 30 years of age; indeed plasma cell granulomas are prominent among the large solitary intrapulmonary lesions in children. Bacterial cultures and skin tests for mycobacteria and fungi have been negative. The prognosis is good even after lobectomy, and probably even after segmental resection. Plasma cell granulomas have structural features and a natural history quite distinct from those of sclerosing hemangioma and myeloma.

Calcifying Fibrous Pseudotumor versus Inflammatory Myofibroblastic Tumor: A Histological and Immunohistochemical Comparison

“…CFP has been described in the soft tissues of the trunk, limbs, peritoneum, epididymis, neck, pleura, chest wall, and mediastinum (1, 3, 8 -14) as well as within a lesion of Castleman disease (15). IMT was originally described in the lung (16) as "plasma cell granuloma." Many other locations have been documented since (7).…”

Jejunal inflammatory myofibroblastic tumor: a rare entity

“…According to some authors it is because of immunologic response to an infectious agent and some believe that they are true neoplasm. 1,4 Associated with Epsrein Barr Virus, Campylobacter jejuni, previous abdominal surgery has been documented. 8,9 The most common site documented is lung.…”

“…2 This tumor is also known by various terms such as inflammatory pseudo tumor, plasma cell granuloma, inflammatory myofibrohistocytic tumor, inflammatory fibrosarcoma. [3][4][5] These terms are often confused with soft tissue sarcoma because of its recurrence tendency and local invasion. 5 Main stay of treatment is surgical resection and in some corticosteroids or NSAIDS may be useful.…”

Plasma cell granuloma of lower lip: A rare case entity

“…[7] We hereby report a case of plasma cell granuloma in lower lip clinically mimicking a malignant tumor which posed a diagnostic dilemma.…”