Plasma Cell Leukemia Presenting as a Chest Wall Mass: A Case Report

Ali, Ahmed Said; Paul, Yonette; Nwabudike, Stanley Madu; Ogbonna, Onyekachi Henry; Grantham, Mica; Taddesse-Heath, Lekidelu

doi:10.1159/000447353

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…"The clinical presentation usually involves symptoms attributed to end-organ damage seen in MM (hypercalcemia, renal failure, anemia, and lytic bone lesions) or to leukemia (leukocytosis, thrombocytopenia, and organomegaly) " [2]. We report a case of PCL with an atypical presentation as a chest wall mass and discuss the diagnostic approach as well as treatment options.…”

Section: Introductionmentioning

confidence: 99%

A Case Report on Plasma Cell Leukemia Presenting as a Chest Wall Mass

Zaghba,

Benmerzouq,

Benjelloun

et al. 2024

J. Adv. Med. Med. Res.

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Plasma cell leukemia (PCL) is an uncommon neoplasm of plasma cells with an aggressive clinical course and a poor outcome, even with the current standard of care. It can occur either de novo (primary PCL) or as a progression of multiple myeloma (MM). This disease has unique diagnostic criteria, but certain genetic markers and clinical features may overlap with multiple myeloma (MM). Due to the low prevalence of PCL, guidelines on its management are extrapolated from the management of MM and are based on small retrospective studies and case reports/series. We report the case of a sixty-nine-year-old man referred to the hematology department for the diagnosis of pPCL, revealed by thoracic plasmacytomas mimicking a thoracic neoplasm. The diagnostic approach, management, and outcomes of PCL are discussed.

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Section: Introductionmentioning

confidence: 99%

A Case Report on Plasma Cell Leukemia Presenting as a Chest Wall Mass

Zaghba,

Benmerzouq,

Benjelloun

et al. 2024

J. Adv. Med. Med. Res.

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“…MM represents 10% of hematological malignancies [ 4 ], with an incidence rate of 4.8/100,000 in the Czech Republic [ 5 ] and global age-standardized incidence rates between 0.1/100,000 and 5.3/100,000 [ 6 ]. MM is characterized by the aberrant expansion of malignant clonal plasma cells (PCs) inside the bone marrow (BM) microenvironment and the presence of abnormal monoclonal proteins in the serum and/or urine [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

LncRNAs LY86-AS1 and VIM-AS1 Distinguish Plasma Cell Leukemia Patients from Multiple Myeloma Patients

Bútová

Vychytilová-Faltejsková

Gregorová

et al. 2021

Biomedicines

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Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Due to modern genomic techniques, the involvement of lncRNAs in tumorigenesis has been revealed; however, information concerning lncRNA interplay in multiple myeloma (MM) and plasma cell leukemia (PCL) is virtually absent. Herein, we aimed to identify the lncRNAs involved in MM to PCL progression. We investigated representative datasets of MM and PCL patients using next-generation sequencing. In total, 13 deregulated lncRNAs (p < 0.00025) were identified; four of them were chosen for further validation in an independent set of MM and PCL patients by RT-qPCR. The obtained results proved the significant downregulation of lymphocyte antigen antisense RNA 1 (LY86-AS1) and VIM antisense RNA 1 (VIM-AS1) in PCL compared to MM. Importantly, these two lncRNAs could be involved in the progression of MM into PCL; thus, they could serve as promising novel biomarkers of MM progression.

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“…In the case of extramedullary myelomas, like PCL, epidural soft tissue masses are reported to be homogenously hypointense on T1-weighted images and hyperintense on T2-weighted images. Other reports of radiographic features of PCL include multi-detector computed tomography (CT) of the abdominal region exhibiting masses attached the chest wall12 or focal lesions of metastatic infiltration to the liver. Positron emission tomography/CT (PET/CT) imaging features have also been reported with increased glucose uptake in the vertebrae, ribs, and pelvis 10.…”

mentioning

confidence: 99%

Radiographic features of plasma cell leukemia in the maxilla: A case report

2016

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Plasma cell leukemia (PCL) is an aggressive form of multiple myeloma where there is hematogenous spread of abnormal plasma cells into the periphery. This is opposed to multiple myeloma, where the abnormal plasma cells stay in the bone marrow. PCL is more common in males than females, and is also more common in African-Americans than Caucasians. Signs and symptoms of PCL include, but are not limited to, renal insufficiency, hypercalcemia, anemia, lytic bone lesions, thrombocytopenia, hepatomegaly, and splenomegaly. Here, we discussed a case of a 71-year-old Caucasian female recently diagnosed with primary PCL with radiographic features of this disease throughout the body, with an emphasis on the maxillofacial skeleton and relevance from a dental standpoint.

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Plasma Cell Leukemia Presenting as a Chest Wall Mass: A Case Report

Cited by 5 publications

References 13 publications

A Case Report on Plasma Cell Leukemia Presenting as a Chest Wall Mass

A Case Report on Plasma Cell Leukemia Presenting as a Chest Wall Mass

LncRNAs LY86-AS1 and VIM-AS1 Distinguish Plasma Cell Leukemia Patients from Multiple Myeloma Patients

Radiographic features of plasma cell leukemia in the maxilla: A case report

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