Plasma cell mucositis of the oral cavity: report of a case and review of the literature

Solomon, Lynn W.; Wein, Richard O.; Rosenwald, Igor B.; Laver, Nora

doi:10.1016/j.tripleo.2008.08.016

Cited by 64 publications

(90 citation statements)

References 19 publications

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“…The initial impression was that of plasma cell mucositis, and further investigations were carried out to characterize the inflammatory infiltrate and distinguish whether the lesion was neoplastic (i.e., multiple myeloma, extramedullary plasmacytoma) or reactive. 1 In situ hybridization confirmed the polyclonal nature of the infiltrate, and immunohistochemistry demonstrated expression of CD3 (Figure 3, B), CD79a (Figure 3, C), CD138, and MUM1 (results not shown), with no expression of CD56 and cyclin-D1 (results not shown). The Ki-67 proliferation fraction exceeded 10% (Figure 3, D).…”

Section: Investigationsmentioning

confidence: 75%

IgG4-related sclerosing disease clinically mimicking oral squamous cell carcinoma

Khurram

Fernando

Smith

et al. 2013

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Investigationsmentioning

confidence: 75%

IgG4-related sclerosing disease clinically mimicking oral squamous cell carcinoma

Khurram

Fernando

Smith

et al. 2013

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…The lesions may occur in the unchanged epithelium (idiopathic, isolated PCM) [7] as well as on the base of inflammatory skin diseases (lichen planus, lichen sclerosus) or epidermal neoplasia (Bowen disease, squamous cell carcinoma) [8]. In many cases patients with PCM also had a history of autoimmune diseases such as rheumatoid arthritis, diabetes, Sjogren syndrome and autoimmune hepatitis [9]. Our patient did not suffer from any autoimmune disease.…”

Section: Discussionmentioning

confidence: 92%

“…In the present case, swollen lips and gums were observed. The mucous membranes are intensely erythematous with the surface described as cobblestone, wart-like, nodular or papillomatous [9,10]. The most frequent symptoms include oral pain, difficulty with swallowing, mouth opening and persistent hoarseness.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma cell mucositis – a rare differential diagnosis for ulceration of oral mucosa

Błażewicz¹,

Barańska‐Rybak²,

Stawczyk-Macieja³

et al. 2015

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Introduction. Plasma cell mucositis (PCM) is a rare condition consisting of plasma cell infiltrate of the mucous membranes that usually involves the genital epithelium. Less frequently lesions are present in the mouth or upper respiratory tract. The etiology of PCM remains unknown. The lesions may occur in the unchanged epithelium (idiopathic, isolated PCM), on the base of inflammatory skin diseases (lichen planus, lichen sclerosus) or cancer (squamous cell carcinoma).Objective. To present a case and draw attention to PCM as a differential diagnosis of lesions within the oral mucous membrane. Case report. We present a patient with painful erosions and erythematous patches located within the mucous membrane of the palate and cheeks lasting more than 5 months. The diagnosis was based on clinical and histopathological examination. Conclusions. The course of PCM includes periods of exacerbations and remissions. Treatment with antibiotics, antifungal agents, local and systemic corticosteroids, isotretinoin or destructive methods usually provides symptomatic relief but does not lead to lesions regression. STRESZCZENIEWprowadzenie. Plazmocytowe zapalenie błon śluzowych (ang. plasma cell mucositis -PCM) jest rzadką jednostką chorobową charakteryzują-cą się naciekiem plazmocytarnym, najczęściej obejmującym nabłonek zewnętrznych narządów płciowych. Znacznie rzadziej zmiany lokalizują się w obrębie jamy ustnej i górnych dróg oddechowych. Etiologia PCM jest nieznana. Zmiany mogą powstać w nabłonku niezmienionym (idiopatyczne, izolowane PCM), jak również na podłożu innych dermatoz zapalnych (liszaj płaski, liszaj twardzinowy) bądź chorób nowotworowych (rak kolczystokomórkowy). Cel pracy. Przedstawienie przypadku PCM i zwrócenie uwagi na konieczność uwzględniania tej jednostki chorobowej w diagnostyce róż-nicowej zmian zlokalizowanych w obrębie błon śluzowych jamy ustnej. Opis przypadku. Prezentujemy przypadek pacjentki ze zmianami w obrębie błon śluzowych policzków i podniebienia w postaci nawracających od 5 miesięcy nadżerek, zmian rumieniowych i ognisk zbielenia z towarzyszącą bolesnością. Rozpoznanie choroby ustalono na podstawie obrazu klinicznego i wyniku badania histopatologicznego.Plasma cell mucositis -a rare differential diagnosis for ulceration of oral mucosa Plazmocytarne zapalenie błon śluzowych -rzadka diagnostyka różnicowa zmian w obrębie błon śluzowych jamy ustnej

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“…In our opinion it is extremely needed to report about lesser-known diseases occurring possibly in the orofacial region. In earlier as well as recent literature only few articles exist dealing with case reports of plasmocytoma (2,3,9), mostly of the extramedullary type in soft tissue emphasizing the clinical manifestation (4,5) or rare combination with other malignancies (6). Epidemiologic evidence of the outcomes based on literature study is still controversial although radical surgery in combination with postoperative irradiation and chemotherapy provides acceptable results (7,8,4).…”

mentioning

confidence: 99%

Letter to the Editor

Stanko¹,

Sobolikova²,

Manesh³

et al. 2017

BLL

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Dear Editor-in-Chief, As practising specialists in the fi elds of oral medicine and maxillofacial surgery we would like to comment on the article published in issue 7/2016 of Bratislava Medical Journal from Zajko J et al (1). In our opinion it is extremely needed to report about lesser-known diseases occurring possibly in the orofacial region. In earlier as well as recent literature only few articles exist dealing with case reports of plasmocytoma (2, 3, 9), mostly of the extramedullary type in soft tissue emphasizing the clinical manifestation (4, 5) or rare combination with other malignancies (6). Epidemiologic evidence of the outcomes based on literature study is still controversial although radical surgery in combination with postoperative irradiation and chemotherapy provides acceptable results (7, 8,4).The authors stated that researchers still do not know exactly the causes of plasmocytoma but there are some factors that could be contributing to this disease. We would like to know whether the authors have noticed any factors of probable combination of factors in their cases? As this is a very rare condition with incidence of 3-4 per 100,000 inhabitants, would it not be even better to include the data from other specialists to create a larger study group for the analysis? The article reveals that all the patients were diagnosed at presentation with tumour-like lesions and had biochemically negative examinations. We would appreciate greatly any advice as e.g. on clinical symptomatology or radiological differential diagnosis that could enable general dentists to state an earlier diagnosis of plasmocytoma in the oral cavity.Despite our questions we would like to express our acknowledgement of the article and reported case with solitary plasmocytoma in the TMJ region. To our best knowledge, this is the fi rst case reported in this specifi c location.

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Plasma cell mucositis of the oral cavity: report of a case and review of the literature

Cited by 64 publications

References 19 publications

IgG4-related sclerosing disease clinically mimicking oral squamous cell carcinoma

IgG4-related sclerosing disease clinically mimicking oral squamous cell carcinoma

Plasma cell mucositis – a rare differential diagnosis for ulceration of oral mucosa

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