Plasma cell vaginitis and cervicitis

Abstract

Introduction: Plasma cell vulvitis (PCV), also known as Zoon's vulvitis, is a rare, chronic inflammatory disease characterized by erythematous plaques with a red, orange hue and increased plasma cells typically affecting the vulva. Case Series: This case series details two clinical presentations of plasma cell mucositis affecting the vagina and cervix, resulting in copious, purulent vaginal discharge. Vaginal and cervical histopathologic findings of a plasmacytic infiltrate confirmed the diagnosis of plasma cell mucositis. Both women were successfully treated with a vaginal estradiol/hydrocortisone/ clindamycin cream and experienced complete resolution of symptoms and physical exam findings. Conclusion: Plasma cell mucositis may be present on the vulva, vagina, and cervix.

Plasma cell vulvitis: A systematic review

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Desquamative Inflammatory Vaginitis and Plasma Cell Vulvitis Represent a Spectrum of Hemorrhagic Vestibulovaginitis

“…A unifying nomenclature may help clinicians and pathologists recognize these as a single phenomenon and facilitate research on etiology, identification, and management. The term “hemorrhagic vestibulovaginitis” describes a spectrum of disease identified by this and previous studies 4,17–20 . The “hemorrhagic” component of the term refers to microscopic features of vascular congestion, fresh hemorrhage, and hemosiderin; hemorrhage is not clinically apparent in milder DIV cases.…”

“…The term "hemorrhagic vestibulovaginitis" describes a spectrum of disease identified by this and previous studies. 4,[17][18][19][20] The "hemorrhagic" component of the term refers to microscopic features of vascular congestion, fresh hemorrhage, and hemosiderin; hemorrhage is not clinically apparent in milder DIV cases. This terminology is not intended to replace traditional labels of DIV and PCV; rather, it provides an intellectual framework to improve recognition and treatment.…”

“…The 3 cases of concurrent histologic PCV and DIV strengthen the hypothesis that these are same condition manifesting differently at vulvar and vaginal sites. Several case reports apply labels of “plasma cell vulvovaginitis” or “plasma cell vaginitis and cervicitis” to cases of red macules extending across vestibule and vagina with biopsies showing dense lymphoplasmacytic infiltrate with hemorrhage or hemosiderin 17–20 . Among 18 patients with DIV in the series by van der Meijden and Ewing, 4 6 (33%) had simultaneous vulvar biopsies suggestive of PCV.…”

Plasma Cell Vulvitis: A Systematic Review

“…There have been 4 cases of plasma cell vaginitis and 4 cases of plasma cell cervicitis documented in the literature 1,42–45 . The age range for diagnosis was 35–67 years.…”