Introduction: Plasma cell vulvitis (PCV), also known as Zoon's vulvitis, is a rare, chronic inflammatory disease characterized by erythematous plaques with a red, orange hue and increased plasma cells typically affecting the vulva. Case Series: This case series details two clinical presentations of plasma cell mucositis affecting the vagina and cervix, resulting in copious, purulent vaginal discharge. Vaginal and cervical histopathologic findings of a plasmacytic infiltrate confirmed the diagnosis of plasma cell mucositis. Both women were successfully treated with a vaginal estradiol/hydrocortisone/ clindamycin cream and experienced complete resolution of symptoms and physical exam findings. Conclusion: Plasma cell mucositis may be present on the vulva, vagina, and cervix.