Plasma concentration of immunoreactive vascular endothelial growth factor and its relation to smoking

Wasada, Taro; Kawahara, Reiko; Katsumori, Kozo; Naruse, Mitsuhide; Omori, Yasue

doi:10.1016/s0026-0495(98)90188-3

Cited by 65 publications

(49 citation statements)

References 6 publications

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“…However, VEGF level did not correlate with the 35 and they found no association of serum VEGF level with retinopathy status in a larger number of diabetic patients. 36 Moreover, serum VEGF level did not correlate with CD34 þ MNCs and c-Kit þ MNCs in this study, which suggests that other unrecognized factors could be present, affecting the initiation of neovascularization and modulation of EPCs in diabetic retinopathy.…”

Section: Discussionmentioning

confidence: 86%

Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy

Lee

Chae

Kim

2005

Eye

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Section: Discussionmentioning

confidence: 86%

Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy

Lee

Chae

Kim

2005

Eye

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“…Previous studies have demonstrated that uremia is characterized by an increased nitric oxide production in the systemic circulation [24,25] and high levels of circulating advanced glycation end-products (AGEs) [26], causing enhanced liberation of vascular endothelial growth factor (VEGF) [27]. Nitric oxide is considered to be a potential candidate to induce alterations in the peritoneal membrane as it regulates vascular tone and reactivity and is involved in vascular proliferation [28].…”

Section: Structural Functional and Molecular Biological Alterations mentioning

confidence: 99%

Recent Concepts in the Molecular Biology of the Peritoneal Membrane – Implications for More Biocompatible Dialysis Solutions

Mortier

Vriese²,

Lameire³

2003

Blood Purif

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This paper reviews some important recent findings on the molecular biology of the peritoneal membrane. It attempts to correlate in vitro and in vivo experimental results with the possible clinical consequences. The most common functional alteration during long-term CAPD is increased peritoneal small-solute transport rate, resulting in impaired ultrafiltration and decreased dialysis efficiency. This contribution first discusses the most relevant advances in the biochemistry and molecular biology of the peritoneal membrane following peritonitis and as consequence of the continuous exposure to unphysiological dialysis fluids. In a second part the preliminary experimental and clinical experience with more biocompatible fluids is summarized. The most relevant structural and functional alterations of the membrane following repeated peritonitis is the consequence of the response of the peritoneum to infective organisms involving the inflammatory cytokines and the interaction between membrane resident cell populations: macrophages, mesothelial cells and fibroblasts. In this setting, human biopsy studies and animal experiments have identified an increase in the peritoneal-associated vasculature, which seems to be the primary cause of increased solute transport. The structural and functional alterations in the membrane in long-term peritoneal dialysis are thought to be the consequence of the toxicity of glucose, either directly or indirectly through the generation of glucose degradation products or the formation of advanced glycation end-products. In particular, an important role for vascular endothelial growth factor and nitric oxide as downstream mediators of the alterations has been suggested. Finally, the last part of this paper reviews the actual and future research aimed at an amelioration of the biocompatibility of the dialysis fluids. Replacing glucose by other osmotic agents, changing the sterilization process, replacing the lactate buffer by bicarbonate, blocking the formation of reactive carbonyl products and of the neoangiogenesis are the most promising changes to enhance the biocompatibility. Finally, gene therapy may in the future have an important contribution. Ex vivo gene therapy involves harvesting peritoneum samples to isolate mesothelial cells that will be genetically modified before re-implantation into the peritoneal cavity.

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“…Although serum VEGF concentrations were found to be elevated in diabetic patients with albuminuria (Abdel Aziz et al 1997, Wasada et al 1998, Hovind et al 2000, it is not known whether urinary VEGF excretion correlates with albuminuria.…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor is increased during early stage of diabetic nephropathy in type II diabetic rats

Ryong

Kang²,

Han

et al. 2004

Journal of Endocrinology

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Vascular endothelial growth factor (VEGF) has been implicated in the pathogenesis of diabetic nephropathy. We investigated serial changes of VEGF in the kidney and assessed whether glomerular and urinary VEGF levels are related to the severity of diabetic nephropathy. Furthermore, we examined the relationship between urinary VEGF levels and the urinary albumin excretion (UAE) rate in Otsuka-Long-Evans-Tokushima-Fatty (OLETF) rats. Glomerular VEGF mRNA expression and protein synthesis were evaluated by the reverse transcriptionpolymerase chain reaction, immunohistochemical staining and in situ hybridization. Urinary levels of VEGF were determined by enzyme-linked immunosorbent assay. UAE was significantly higher in OLETF rats than in control Long-Evans-Tokushima-Fatty (LETO) rats throughout the study period. Urinary VEGF levels were significantly higher from 25 to 37 weeks, and then gradually reduced until 55 weeks, although the levels were still higher than those in control rats. Urinary VEGF levels also showed a significant positive correlation with UAE (r=0·262, P=0·045) and serum creatinine (r=0·398, P=0·044), and were found to be independently correlated with UAE by Spearman's rank correlation. By immunohistochemical staining and in situ hybridization, VEGF was mainly detected in the podocytes in the glomeruli. Interestingly, a significant increase in VEGF mRNA expression was observed in the early period of diabetic nephropathy, and this was associated with increased urinary VEGF excretion. Thus, the overproduction of VEGF in the diabetic kidney may participate in the pathogenesis of early-stage diabetic nephropathy.

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Plasma concentration of immunoreactive vascular endothelial growth factor and its relation to smoking

Cited by 65 publications

References 6 publications

Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy

Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy

Recent Concepts in the Molecular Biology of the Peritoneal Membrane – Implications for More Biocompatible Dialysis Solutions

Vascular endothelial growth factor is increased during early stage of diabetic nephropathy in type II diabetic rats

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