2005
DOI: 10.1038/sj.eye.6701920
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Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy

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Cited by 93 publications
(74 citation statements)
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“…In contrast to diabetic neuropathy, which is characterised by microvascular dysfunction, patients with diabetic retinopathy present significant capillary proliferation in the retina [36]. We report here a significant reduction in putative EPCs in patients with diabetic retinopathy, a finding which agrees with some, but not all, published studies [37,39,40]. How angiogenesis can be increased in the presence of reduced EPC levels in these patients is not clear and actually represents a paradox [39].…”
Section: Discussionsupporting
confidence: 80%
“…In contrast to diabetic neuropathy, which is characterised by microvascular dysfunction, patients with diabetic retinopathy present significant capillary proliferation in the retina [36]. We report here a significant reduction in putative EPCs in patients with diabetic retinopathy, a finding which agrees with some, but not all, published studies [37,39,40]. How angiogenesis can be increased in the presence of reduced EPC levels in these patients is not clear and actually represents a paradox [39].…”
Section: Discussionsupporting
confidence: 80%
“…Finally, a recent study has demonstrated an increased number of CD34+ mononuclear cells in patients affected by type 2 diabetes with both non-proliferative and proliferative retinopathy [10]. Although of interest, these results cannot be easily compared with the ones described above as EPCs represent only one of the different classes of circulating cells staining positively for CD34+ [1].…”
mentioning
confidence: 42%
“…It has been postulated that low EPCs in peripheral blood may have a role in cardiovascular disease, and we have demonstrated that EPCs are reduced in macrovascular diabetes complications (5,6). On the other hand, an excess of EPCs may be involved in pathologic neoangiogenesis of cancer and proliferative retinopathy (7,8). Therefore, diabetes complications may be associated with both decreased and increased EPCs.…”
mentioning
confidence: 85%