1992
DOI: 10.1042/cs0830437
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Plasma concentrations and comparisons of brain natriuretic peptide and atrial natriuretic peptide in normal subjects, cardiac transplant recipients and patients with dialysis-independent or dialysis-dependent chronic renal failure

Abstract: 1. We have developed a radioimmunoassay for the measurement of immunoreactive brain natriuretic peptide (1-32) in human plasma. Simultaneous measurements of atrial natriuretic peptide have also been carried out to allow for direct comparison between circulating brain natriuretic peptide and atrial natriuretic peptide. Plasma levels of immunoreactive brain natriuretic peptide (means +/- SEM) were 1.1 +/- 0.1 pmol/l in 36 normal healthy subjects and were significantly elevated in cardiac transplant recipients (1… Show more

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Cited by 110 publications
(95 citation statements)
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“…NT-proBNP and BNP were influenced by age and renal dysfunction in accordance with other studies. [16][17][18][19] In contrast with other studies, they were not influenced by gender nor by the use of renin-angiotensin system blockers. [20][21][22] A limitation of the study is the small population of 103 nursing home residents, in one centre, which could lead to a selection bias in arriving at the prevalence of CHF of 23%.…”
Section: Discussioncontrasting
confidence: 66%
“…NT-proBNP and BNP were influenced by age and renal dysfunction in accordance with other studies. [16][17][18][19] In contrast with other studies, they were not influenced by gender nor by the use of renin-angiotensin system blockers. [20][21][22] A limitation of the study is the small population of 103 nursing home residents, in one centre, which could lead to a selection bias in arriving at the prevalence of CHF of 23%.…”
Section: Discussioncontrasting
confidence: 66%
“…A previous report demonstrated that high plasma BNP was an independent predictor of a stroke event in hospitalized congestive heart failure patients (14). Moreover (17), hypertrophic cardiomyopathy (18), pulmonary embolism (19), and Takotsubo cardiomyopathy (20) (22,23). Therefore, we propose the following algorithm for diagnosing stroke subtype using BNP (Fig.…”
Section: F I G U R E 1 Me a N ± S D P L A S Ma B Np L E V E L S A Nmentioning
confidence: 99%
“…2 Furthermore, decreased clearance of the peptides by the kidney may have further elevated the plasma levels, since these patients had slightly increased plasma creatinine, and both BNP and ANP are elevated in patients with decreased renal function. 3 Although plasma levels of BNP and ANP were similar in the cardiac transplant recipients, there were clear differences in the molecular circulating forms present in human plasma (Figure 2). BNP immunoreactivity consisted of two forms, a low molecular weight form corresponding to BNP (1-32) and a high molecular weight form (Figure 2), possibly the complete prohormone proBNP (1-108) with the 32 amino acid peptide BNP (1-32) at its carboxyl-terminal end.…”
Section: Discussionmentioning
confidence: 98%
“…The column was calibrated using synthetic human BNP (1-32) and ANP (99-126) standards. Pooled plasma from cardiac transplant recipients (48 ml) was extracted on Sep-Pak cartridges, reconstituted in a 0.5 ml volume of assay buffer 3 and loaded onto the column. Fractions collected were tested for immunoreactivity using the BNP and ANP radioimmunoassays.…”
Section: Gel Filtration Of Extracted Plasmamentioning
confidence: 99%
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