Plasma concentrations of ADH in conscious and anesthetized dogs

Bonjour, J. P.; Malvin, RL

doi:10.1152/ajplegacy.1970.218.4.1128

Cited by 77 publications

(35 citation statements)

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“…However, the results of chronic experiments such as these are obviously not directly comparable with those of the present investigation in which the period studied after haemorrhage was of relatively short duration. The mean prehaemorrhage plasma vasopressin concentration in the Long Evans rats was relatively high, presumably because of anaesthesia and the stress of surgery (Bonjour & Malvin, 1970 (Valtin, Sawyer & Sokol, 1965;Jones & Lee, 1967;Lee & Williams, 1972), and since oxytocin has measurable antidiuretic activity if released in sufficient quantity (Bisset & Lewis, 1962), the present finding supports the view that haemorrhage stimulates the independent release of vasopressin (Chaudhury & Walker, 1958;Ginsburg & Smith, 1959;Beleslin et al 1967;Schrier, Verroust, Jones, Fabian, Lee & de Wardener, 1968).…”

Section: Discussionmentioning

confidence: 95%

The role of vasopressin in blood pressure regulation immediately following acute haemorrhage in the rat

Laycock¹,

Penn²,

Shirley³

et al. 1979

The Journal of Physiology

112

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SUMMARY1. The possible pressor effect of vasopressin immediately after acute haemorrhage has been studied using anaesthetized Brattleboro rats with diabetes insipidus and rats of the Long Evans parent strain.2. A blood loss of 0.5 % of the body weight caused a significant decrease in mean arterial blood pressure, measured 10 min later, in Brattleboro rats, whereas this degree of haemorrhage was non-hypotensive in the control Long Evans rats.Following subsequent blood losses (each of 0-5 % of the body weight), mean arterial blood pressure in Brattleboro rats was always significantly lower than in Long Evans rats.3. While no antidiuretic activity was at any time found in the plasma of Brattleboro rats, haemorrhages greater than 1 % of the body weight were associated with marked increases in plasma arginine vasopressin (AVP) of Long Evans rats. 4. When Brattleboro and Long Evans rats were subjected to a single haemorrhage of 2 % of the body weight, the immediate decrease in arterial blood pressure was similar in the two groups. However, 5 and 10 min after the haemorrhage the arterial blood pressure was significantly higher in the Long Evans rats. When vasopressin was infused into Brattleboro rats so that plasma levels of the hormone approached those found in Long Evans rats, the mean arterial blood pressure 0, 5 and 10 min after haemorrhage was similar to that in the Long Evans animals. 5. It is concluded that in the anaesthetized rat, vasopressin plays an important role in the regulation of arterial blood pressure during the period immediately following acute haemorrhage.

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Section: Discussionmentioning

confidence: 95%

The role of vasopressin in blood pressure regulation immediately following acute haemorrhage in the rat

Laycock¹,

Penn²,

Shirley³

et al. 1979

The Journal of Physiology

112

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“…The anti-diuretic activity of the plasma in the rat, cat and dog is elevated during anaesthesia with ether, urethane and with many barbiturates (Dicker, 1953;Ginsberg & Brown, 1957;Beleslin, Bisset, Haldar & Polak, 1966;Bonjour & Malvin, 1970). Chloralose has been reported not to increase anti-diuretic activity of plasma (Ginsberg & Brown, 1957).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Anaesthetics on the Increase in the Water Permeability of the Toad Bladder Induced by Vasopressin

Grey

Ullmann

1974

British J Pharmacology

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1Single lobes of the bladder of Bufo marinus were isolated and filled with, and suspended in, oxygenated Ringer solution. The fluid in contact with the outside (serosa) of the lobes had a total osmolarity of 225 m-osmol/litre, and that bathing the inside (mucosa) of 45 m-osmol/ litre. 2 Osmotic water flow from mucosa to serosa was measured by weighing the lobes every 30 minutes. It was negligible unless vasopressin was added to the serosal bath. Standard concentrations of either 1.25 or 6.25 mu/ml were used to render the bladder lobes permeable to water.3 The presence in the serosal medium of pentobarbitone or thiopentone in concentrations ranging from 0.25 to 2.5 mM, or of chloralose in concentrations ranging from 0.65 to 6.5 mM, diminished the increase in water permeability induced by vasopressin. 4 The three anaesthetics exerted similar inhibitory effects on the action of vasopressin from the serosal and from the mucosal surface of the bladder. 5 In the presence of a constant high concentration of anaesthetic, increasing the concentration of vasopressin over three orders of magnitude led to stepwise increases of osmotic water flow out of the lobes, although at every dose level the effect of vasopressin was depressed by the anaesthetic. However, it was not completely abolished even if the concentration of vasopressin was close to threshold. 6 The increase in water permeability of the bladder induced by 3',5'-adenosine monophosphate (cyclic AMP) was also depressed by the three anaesthetics. 7 Possible explanations of the findings are discussed.

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“…The introduction of sensitive techniques for AVP measurement by radioimmunoassay has given fresh impetus to this re-evaluation. 9 In the case of opioids the relationship with the release of AVP is uncertain, as is shown by the work of Aziz, et al These authors demonstrated that the response of plasma AVP to the intracerebroventricular administration of morphine is both dose and time dependent. Small doses of morphine inhibit and larger doses first stimulate and then subsequently inhibit the release of AVP.…”

Section: Discussionmentioning

confidence: 99%

Arginine vasopressin response to anaesthesia produced by halothane, enflurane and isoflurane

Leighton

Lim

Wilson

1982

Canad. Anaesth. Soc. J.

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Some of the effects of inhalational anacsthetics may be mcdiatcd by 13-endorphins acting on opioid receptors. Stimulation of such receptors has been shown both to promote and to inhibit the release of arginine vasopressin (AVP). Ten rabbits were studied to determine the response of plasma AVP to a predetermined time/concentration "dose" of halothane, enflurane or isoflurane. Abolition of corneal rcflex was used as a standard end-point. Plasma samples were obtained from awake animals and after exposure to the anaesthetics, the sequence being randomly assigned. No significant changes in plasma AVP concentrations were observed when predetermined time/concentration "doses" of the agents were administered to the rabbits. Anaesthesia produced by halothane, enflurane or isoflurane, therefore, is not necessarily accompanied by changes in plasma AVP.

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Plasma concentrations of ADH in conscious and anesthetized dogs

Cited by 77 publications

References 0 publications

The role of vasopressin in blood pressure regulation immediately following acute haemorrhage in the rat

The role of vasopressin in blood pressure regulation immediately following acute haemorrhage in the rat

The Influence of Anaesthetics on the Increase in the Water Permeability of the Toad Bladder Induced by Vasopressin

Arginine vasopressin response to anaesthesia produced by halothane, enflurane and isoflurane

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