Plasma concentrations of alpha-tocopherol and urate in patients with different types of cancer

Abiaka, Clifford; Al-Awadi, Farida; Gulshan, S.; Al‐Sayer, H.; Behbehani, A.; Farghaly, Medhat M.; Simbeye, Amos

doi:10.1046/j.1365-2710.2001.00350.x

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…This interaction promotes recycling of α-tocopherol radicals and regeneration of α-tocopherol [ 38 ]. Vitamin E is the major lipid-soluble antioxidant present in lipid membranes and human plasma lipoproteins [ 39 ]. It exists in eight different isoforms, of which α-tocopherol is the most biologically active form.…”

Section: Discussionmentioning

confidence: 99%

An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases

et al. 2016

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The present study was aimed to evaluate the levels of oxidative stress markers in breast diseases by measuring the 8-hydroxy-2-deoxyguanosine (8-OHdG), vitamin A, vitamin C, vitamin E, and total antioxidant status (TAS) alterations in relation to cell proliferation activity and disease progression. Significant increases in the level of the oxidative damage marker 8-OHdG and cell proliferation activity were observed in breast carcinoma patients in comparison to benign and normal controls, which were accompanied by a significant decrease in non-enzymatic antioxidants and TAS concentrations (p < 0.05). 8-OHdG and cell proliferation levels were negatively correlated with non-enzymatic antioxidants, namely, vitamin A, vitamin C, and vitamin E levels and total antioxidant activity. Altered levels of biomarkers of oxidative stress and cell proliferation activity among the malignant, the benign, and the controls suggest a correlation of increased oxidative stress and cell proliferation activity in the progression of disease in breast carcinoma patients. In conclusion, our results showed that the characterized biomarkers (i.e., low levels of vitamin A, C and D, and the TAS status; and high levels of 8-OHdG) could be used as a suitable method for detecting subjects with malignant and benign breast diseases.

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Section: Discussionmentioning

confidence: 99%

An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases

et al. 2016

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“…Cancer patients have been shown to have low concentrations of tissue and plasma tocopherols compared to their healthy counterparts (Abiaka et al, 2001; Goodman et al, 2003; McMillan et al, 2002). The functions of tocopherols in scavenging lipid peroxyl radicals in biological membranes are well documented (Baba et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Modulatory effects of α- and γ-tocopherols on 4-hydroxyestradiol induced oxidative stresses in MCF-10A breast epithelial cells

Lee

Kim

et al. 2009

Nutr Res Pract

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The elevated level of circulating estradiol increases the risk of breast tumor development. To gain further insight into mechanisms involved in their actions, we investigated the molecular mechanisms of 4-hydroxyestradiol (4-OHE2) to initiate and/or promote abnormal cell growth, and of α- or γ-tocopherol to inhibit this process. MCF-10A, human breast epithelial cells were incubated with 0.1 µM 4-OHE2, either with or without 30 µM tocopherols for 96 h. 4-OHE2 caused the accumulation of intracellular ROS, while cellular GSH/GSSG ratio and MnSOD protein levels were decreased, indicating that there was an oxidative burden. 4-OHE2 treatment also changed the levels of DNA repair proteins, BRCA1 and PARP-1. γ-Tocopherol suppressed the 4-OHE2-induced increases in ROS, GSH/GSSG ratio, and MnSOD protein expression, while α-tocopherol up-regulated BRCA1 and PARP-1 protein expression. In conclusion, 4-OHE2 increases oxidative stress reducing the level of proteins related to DNA repair. Tocopherols suppressed oxidative stress by scavenging ROS or up-regulating DNA repair elements.

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“…Furthermore, hyperuricemia (z 7 mg/dL) is often accompanied with the bmetabolic syndromeQ [4]. Although urate is an antioxidant, its association with cancer risk is unclear [5].…”

Section: Introductionmentioning

confidence: 99%

Possible interactions of the endothelial constitutive nitric oxide synthase genotype with alcohol drinking and walking time for high serum uric acid levels among Japanese

et al. 2005

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Plasma concentrations of alpha-tocopherol and urate in patients with different types of cancer

Abstract: The data suggest that although alpha-tocopherol and urate provide important antioxidant defence in cancer, the association between their levels is weak.

Cited by 9 publications

References 31 publications

An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases

An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases

Modulatory effects of α- and γ-tocopherols on 4-hydroxyestradiol induced oxidative stresses in MCF-10A breast epithelial cells

Possible interactions of the endothelial constitutive nitric oxide synthase genotype with alcohol drinking and walking time for high serum uric acid levels among Japanese

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