Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow

Yücel, Habil; Özaydın, Mehmet; Doğan, Abdullah; Erdoğan, Doğan; Türker, Yasin; Ceyhan, Betül Mermi; Sütçü, Recep

doi:10.3109/00365513.2012.699637

Cited by 20 publications

(22 citation statements)

References 22 publications

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“…The first frame was defined by a column of contrast extending across >70% of the arterial lumen anterograde motion. 9 The normal frame counts for the left anterior descending (LAD) coronary artery is 36 + 2.3 frames, and the mean for the left circumflex coronary artery is 22.2 + 3.8 frames. Hence, the longer LAD frame counts are corrected by dividing by 1.7 to derive the corrected TFC as described earlier.…”

Section: Cardiac Catheterization and Documentation Of Tfcmentioning

confidence: 99%

“…The right coronary artery is 21.7 + 2.8 frames. 9 Coronary angiograms were judged with regard to smooth appearance, luminal wall irregularities, epicardial local or diffuse caliber reduction, and stenosis. Coronary arteries were classified as normal on the basis of visual assessment of the absence of any luminal irregularities.…”

Section: Cardiac Catheterization and Documentation Of Tfcmentioning

confidence: 99%

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Carotid Intima-Media Thickness in Patients With Slow Coronary Flow and Its Association With Neutrophil-to-Lymphocyte Ratio

Cingoz

İyisoy

Demırkol

et al. 2013

Clin Appl Thromb Hemost

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Section: Cardiac Catheterization and Documentation Of Tfcmentioning

confidence: 99%

Section: Cardiac Catheterization and Documentation Of Tfcmentioning

confidence: 99%

Carotid Intima-Media Thickness in Patients With Slow Coronary Flow and Its Association With Neutrophil-to-Lymphocyte Ratio

Cingoz

İyisoy

Demırkol

et al. 2013

Clin Appl Thromb Hemost

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“…Increased serum uric acid (27), circulating soluble CD40 (28), resistin (29), asymmetric dimethylarginine, homocysteine levels (30), besides decreased serum paraoxonase activity (2), serum adiponectin (31), and nitric oxide (30), levels was reported to be associated with the presence of CSF. Ahead of inflammatory and oxidative stress markers, markers of blood viscosity were also reported to be related with CSF (32).…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume is not associated with coronary slow flow: A retrospective cohort study

Kaya

Günebakmaz²,

Yıldız³

et al. 2015

Anadolu Kardiyol Derg

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Objective:To investigate mean platelet volume (MPV) levels in patients with coronary slow flow (CSF).Methods:465 stable angina pectoris cases with angiographically normal coronary arteries were recruited [coronary slow flow group (n=76), control group (n=389)] in the observational retrospective cohort study. Clinical, biochemical and demographic variables including MPV were noted and coronary blood flow was assessed with TIMI frame count (TFC).Results:Gender, smoking, height, serum creatinine, uric acid levels, hemoglobin, waist/hip ratio, systolic blood pressure but not MPV were significantly different among groups. Independent predictors of CSF were height (p=.029) and serum uric acid level (p=.045). Gender, height, weight, hip circumference, systolic blood pressure, fasting blood glucose, serum urea, creatinine, uric acid levels, hemoglobin and platelet count were associated with mean TFC whereas independent predictors of mean TIMI frame count were height (p=.010) and serum uric acid level (p=.041).Conclusion:Height and serum uric acid level but not MPV were independent predictors of both CSF and mean TFC.

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“…Pekdemir et al showed that endothelin-1 (ET-1) was higher and NO concentration was lower in patients with SCF than in a matched group of control subjects, and it was suggested that this situation was due to endothelial dysfunction 22. The plasma levels of NO were also found to be lower in patients with SCF than in normal subjects 23,24…”

Section: Discussionmentioning

confidence: 99%

Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow

Taşolar¹,

Eyyüpkoca²,

Aktürk³

et al. 2013

CVJA

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Background: Endothelial dysfunction plays a key role in the aetiopathogenesis of slow coronary flow (SCF) even if there is no obstructive epicardial lesion. Reduced plasma levels of endothelial nitric oxide synthase (eNOS) are an important indicator of endothelial dysfunction. We aimed to determine plasma levels of eNOS and their relationship with exercise in patients with SCF. Methods: Twenty-two patients with SCF in at least one coronary artery and 17 healthy individuals were included in this study. The TIMI frame count method was used to determine SCF. Plasma levels of eNOS before and after effort were determined in the patient and control groups. Results: Basal eNOS levels in the patient group were lower than in the control group (p = 0.040), and plasma eNOS levels after exercise decreased more significantly in the patient group compared to the control group (p = 0.002). Median decreases of eNOS in response to exercise were higher in the SCF group than in the control group (p < 0.001), and the decrease observed in the control group was not statistically significant (p = 0.35). There were significantly negative correlations between TIMI frame count and plasma levels of eNOS at baseline and after exercise (r = -0.51, p = 0.015, r = -0.58, p = 0.005, respectively). Moreover, there was also a positive correlation between the rate-pressure product and plasma levels of eNOS after exercise in patients with SCF (r = 0.494, p = 0.019). Conclusion: Our findings indicate an important pathophysiological relationship between the severity of SCF in which endothelial dysfunction plays a role in its pathogenesis and the level of circulating plasma levels of eNOS.

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Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow

Abstract: Our results suggest that plasma concentrations of ADMA and homocysteine are increased in SCF and also that these are independent predictors of SCF.

Cited by 20 publications

References 22 publications

Carotid Intima-Media Thickness in Patients With Slow Coronary Flow and Its Association With Neutrophil-to-Lymphocyte Ratio

Carotid Intima-Media Thickness in Patients With Slow Coronary Flow and Its Association With Neutrophil-to-Lymphocyte Ratio

Mean platelet volume is not associated with coronary slow flow: A retrospective cohort study

Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow

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