1974
DOI: 10.1016/s0022-3476(74)80127-7
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Plasma concentrations of phenobarbital in the neonate during prophylaxis for neonatal hyperbilirubinemia

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1976
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Cited by 25 publications
(12 citation statements)
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“…On the contrary, Wallin et al ( 1974) and Boreus et al (1975) could demonstrate that the oral absorp. tion of phenobarbitone is not only delayed but also reduced in newborns up to 15 days of age, while the drug is effiCien tly and more rapidly absorbed (peaks at 2 to 4 hours) if administered by the intramuscular rou te.…”
Section: Absorptionmentioning
confidence: 90%
“…On the contrary, Wallin et al ( 1974) and Boreus et al (1975) could demonstrate that the oral absorp. tion of phenobarbitone is not only delayed but also reduced in newborns up to 15 days of age, while the drug is effiCien tly and more rapidly absorbed (peaks at 2 to 4 hours) if administered by the intramuscular rou te.…”
Section: Absorptionmentioning
confidence: 90%
“…Symptomatic treatment often involves termination of acute seizures with intravenous diazepam and subsequent maintenance therapy with phenobarbitone (Holden and Freeman, 1975), after excluding disorders requiring specific therapy, such as hypoglycaemia. The rate of elimination of phenobarbitone is slow especially in newborn infants in whom the mean plasma half-life is about 200 hours (Wallin et al, 1974;Boreus et al, 1975). Therefore, initiation of phenobarbitone maintenance therapy without a loading dose implies a substantial delay before achievement of steady-state plasma concentrations (Wallin et al, 1974;Rosen and Pippenger, 1975).…”
mentioning
confidence: 99%
“…The rate of elimination of phenobarbitone is slow especially in newborn infants in whom the mean plasma half-life is about 200 hours (Wallin et al, 1974;Boreus et al, 1975). Therefore, initiation of phenobarbitone maintenance therapy without a loading dose implies a substantial delay before achievement of steady-state plasma concentrations (Wallin et al, 1974;Rosen and Pippenger, 1975).…”
mentioning
confidence: 99%
“…injection the absorption rate of the lyophilized form of injectable phénobarbital being tested is rapid. Peak plasma levels are reached more rapidly than with other injectable forms giving mean maxi mal plasma levels within 2^4 h or more [Brachet-Liermain et al, 1975;Jailing, 1975;Royer et al, 1976;Wallin et al, 1974]. The mean ratio Cmax/dose, apparently higher in term (r = 1.25) than in preterm newborns (r= 1.1), is in good agreement with previous studies which showed that during phénobarbital therapy plasma levels are lower in term than in pre term newborns [Alix, 1982], and that the Cmax/dose ratio increases with age in infants and children [Rossi et al, 1979].…”
Section: First Part Of Curvesmentioning
confidence: 99%
“…The half-lives of phénobarbital in preterm neonates appear to be extremely variable and prolonged (100-500 h) compared to term neonates (100-200 h) or babies and infants (65 h) [Boréus et al, 1978;Boutroy et al, 1979;Centraud, 1978;Gold et al, 1980;Heimann and Gladtke, 1977;Painter et al, 1978;Pitlick et al, 1978;Royer et al, 1976;Wallin et al, 1974]. The variability observed in the group of the same postnatal age seems to be related to the conditions of measurement of the kinetic model and to calculation of the pharmacokinetic parameters.…”
Section: Second Part Of Curvesmentioning
confidence: 99%