Plasma Copper and Bone Mineral Density in Osteopenia: An Indicator of Bone Mineral Density in Osteopenic Females

Chaudhri, M. Anwar; Kemmler, Wolfgang; Harsch, Igor Alexander; Watling, R. J.

doi:10.1007/s12011-008-8299-0

Cited by 19 publications

(14 citation statements)

References 9 publications

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“…Elemental analysis of plasma samples was carried out using a combination of solution-based ICP-AES (Thermo Scientific iCAP 6000) for the determination of Na, Mg, P, S, K, Ca and Fe, and solution-based ICP-MS (Agilent Technologies 7500cs) for the determination of Al, B, Si, Ti, Sc, V, Cr, Mn, Co, Ni, Zn, Cu, Ga, Ge, As, Se, Rb, Sr, Y, Zr, Nb, Mo, Cd, In, Sn, Sb, Te, Cs, Ba, La, Ce, Nd, Hf, W, Tl, Pb, Bi, Th, and U as reported earlier [13,14]. Sample preparation for elemental analysis consisted of dissolving a known mass (accurately weighed to three significant figures in gram mass) of sample in a mixture of high purity (quartz sub-boiling redistilled) nitric acid and hydrogen peroxide 20% v/v, in 50 ml volume, acid-washed polyethylene tubes, under individual reflux in a water bath for 24 h. A series of certified reference materials (CRMs), (IAEA-A-13 animal blood; NIST SRM 1547 peach leaves; NIST SRM 1515 apple leaves and NIST SRM 1573a tomato leaves) was dissolved using the same procedure.…”

Section: Methodsmentioning

confidence: 85%

Evaluation of Plasma Trace Element and Mineral Status in Children and Adolescents with Phenylketonuria Using Data from Inductively-Coupled-Plasma Atomic Emission and Mass Spectrometric Analysis

Knerr

Blessing²,

Seyferth

et al. 2013

Ann Nutr Metab

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Background: Phenylketonuria (PKU) is caused by a severe phenylalanine hydroxylase deficiency; the mainstay of treatment is a low-phenylalanine diet. A diet which is so restrictive is associated with a risk of nutritional deficiencies. We investigated plasma concentrations for 46 elements, including minerals and trace elements. Methods: We enrolled 20 children and adolescents with PKU and 20 matched controls. Multi-elementary quantification was carried out by solution-based inductively coupled plasma atomic emission spectroscopy (ICP-AES) and ICP mass spectrometry (ICP-MS). Results: With the exception of manganese and aluminium, no significant differences were found for element levels between PKU patients and controls. As a trend, manganese levels were lower in PKU patients than in control subjects (p < 0.05) but were within the reference range. There was a positive linear relationship between manganese and tyrosine levels in subjects with PKU (r² = 0.2295, p < 0.05). If detectable, potentially toxic elements were only identified in ultra-trace quantities in plasma samples of either group; aluminium levels were found to be slightly higher in PKU subjects than in controls (p < 0.01). Conclusion: The combination of ICP-AES and ICP-MS data is a useful diagnostic tool for element quantification at a high analytical rate and for monitoring bio-element status, e.g. in patients on a restrictive diet.

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Section: Methodsmentioning

confidence: 85%

Evaluation of Plasma Trace Element and Mineral Status in Children and Adolescents with Phenylketonuria Using Data from Inductively-Coupled-Plasma Atomic Emission and Mass Spectrometric Analysis

Knerr

Blessing²,

Seyferth

et al. 2013

Ann Nutr Metab

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“…Chaudhri et al (Chaudhri et al 2009) found a linear relationship between serum Cu values and bone density in post-menopausal women. By contrast, the men in our study with low serum Cu levels had BMD similar to those of the reference group.…”

Section: Discussionmentioning

confidence: 99%

“…The importance of Cu in bone health has been studied in the context of Cu deficiency and osteoporosis (Palacios 2006; Chaudhri et al 2009; Lowe et al 2002). Chaudhri et al (Chaudhri et al 2009) found a linear relationship between serum Cu values and bone density in post-menopausal women.…”

Section: Discussionmentioning

confidence: 99%

High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics

Gaier

Kleppinger

Ralle

et al. 2012

Experimental Gerontology

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Serum Cu levels rise with age and high Cu/Zn ratios are linked with multiple-cause mortality in the elderly. The relationships of these parameters to measures of musculoskeletal health and frailty have not yet been analyzed. We used inductively coupled mass spectrometry to assess serum levels of Cu and Zn and probed for relationships between serum Cu levels and the Cu/Zn ratio with specific measures of bone, physical and overall health in a cohort of 144 frail elderly men. Subjects were divided into quintiles based on serum metal levels and comparisons for functional measures were made between the reference (middle) group and the low and high groups. Subjects’ serum metal values were normally distributed. We found significant correlations between high Cu/Zn ratios and deficits in femoral bone mineral density, measures of speed and strength, muscle mass and hematocrit. High Cu/Zn ratios were also correlated with decreased triglycerides and increased reliance on ADL assistance. This study identifies specific deficits associated with high Cu/Zn ratios that span multiple organ systems and supports earlier studies indicating that serum Cu levels and the Cu/Zn ratio may serve as useful predictive biomarkers for poor health in the elderly.

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“…Many epidemiological studies with mixed findings have investigated the associations between serum copper levels, cardiovascular disease and neurodegenerative diseases [9] , [10] , [11] , [12] . However, the association between copper status and the risk of osteoporosis and related diseases has been examined by only few observational studies and remains controversial because of inconsistent results [13] , [14] , [15] , [16] , [17] , [18] . Sadeghi et al.…”

Section: Introductionmentioning

confidence: 99%

Serum copper levels are associated with bone mineral density and total fracture

Qiao

et al. 2018

Journal of Orthopaedic Translation

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BackgroundBoth copper deficiency and overexposure have been associated with adverse health effects. Evidence linking copper to bone mineral density (BMD) and total fracture, however, is limited.MethodsThis nationally representative cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (2011–2014) in the United States. Using unadjusted and multivariate adjusted logistic regression analyses and a two-piecewise linear regression model with a smoothing function, we evaluated the associations between serum copper levels, bone mineral density and total fracture in 722 participants.ResultsThe study sample (n = 722, mean age: 56.47 ± 11.55 y) represented a population of which 47.2% were men; 43.91% were non-Hispanic white, 18.84% non-Hispanic black and 13.71% Mexican American; 25.9% had total fracture. In the multivariate logistic regression analysis, individuals in the lowest category (<98.5 μg/dL) of serum copper concentration had 0.049 g/cm2 lower total femur BMD and 0.045 g/cm2 lower femoral neck BMD than those in the second concentration category (98.5–114 μg/dL). Individuals in the highest category (≥134 μg/dL) of serum copper concentration had an approximately 4-fold increase in the risk of total fracture than those in the second concentration category. There were no significant associations between per 10 μg/dL increases in serum copper levels and total fracture in multivariate logistic regression analysis after multivariate adjustment (all p > 0.05). However, a differential association between serum copper levels and total fractures between men and women was observed (odds ratio = 1.81, 95% confidence interval 1.08–3.03, p = 0.026 for men and odds ratio = 1.07, 95% confidence interval 0.86–1.32, p = 0.552 for women).ConclusionModerate serum copper levels are critically important for bone health. Lower serum copper levels are significantly associated with decreased BMD in the total femur and femoral neck. Higher serum copper levels are significantly associated with increased total fracture, especially in men.The Translational Potential of this ArticleThe impact of serum copper concentrations on bone mineral density and total fracture can provide insights into clinical application of copper-containing supplements and biomaterials.

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Plasma Copper and Bone Mineral Density in Osteopenia: An Indicator of Bone Mineral Density in Osteopenic Females

Cited by 19 publications

References 9 publications

Evaluation of Plasma Trace Element and Mineral Status in Children and Adolescents with Phenylketonuria Using Data from Inductively-Coupled-Plasma Atomic Emission and Mass Spectrometric Analysis

Evaluation of Plasma Trace Element and Mineral Status in Children and Adolescents with Phenylketonuria Using Data from Inductively-Coupled-Plasma Atomic Emission and Mass Spectrometric Analysis

High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics

Serum copper levels are associated with bone mineral density and total fracture

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