Plasma D-Dimer Concentrations and Risk of Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Zhou, Zhike; Liang, Yifan; Zhang, Xiaoqian; Xu, Junjie; Kang, Kexin; Qu, Huiling; Zhao, Chuansheng; Zhao, Mei

doi:10.3389/fneur.2018.01114

Cited by 17 publications

(13 citation statements)

References 43 publications

(37 reference statements)

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“…A cohort of 39 patients was recruited, with 35 Baseline POC biomarker values and calculated indexes according to day 90 mRS are presented in Table II. Higher values in the unfavorable outcome group were documented for RDWa, GRA, NLR, PLR, SII, hs-CRP and D-dimer, but the differences were only significant for D-dimer (P<0.001).…”

Section: Resultsmentioning

confidence: 99%

Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study

et al. 2022

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Spontaneous intracerebral hemorrhage (sICH) results in high morbidity and mortality rates, thus identifying strategies for timely prognosis and treatment is important. The present study aimed to analyze the relationship between emergency department point-of-care (POC) blood biomarkers and day 90 functional outcome (FO) in patients with acute (<8 h) sICH. On-site POC determinations, including complete blood count, glucose, cardiac troponin I, D-dimer and C-reactive protein, and derived inflammatory indexes were performed for a cohort of 35 patients. The primary endpoint was a favorable day 90 FO (modified Rankin Score ≤3). Secondary endpoints included early neurological worsening (ENW), day 7/discharge neurological impairment, day 90 independence assessment (Barthel Index <60), hematoma enlargement and perihematomal edema (PHE) growth. A favorable three-month FO was reported in 16 (46%) participants. Older age, previous history of ischemic stroke and initial imagistic parameters, including intraventricular hemorrhage, enlarged contralateral ventricle and cerebral atrophy, significantly predicted an unfavorable FO. The admission D-dimer similarly predicted day 90 FO and the independence status, along with ENW and a more severe day 7/discharge neurological status. The D-dimer also correlated with the initial neurological status and PHE. PHE growth correlated with granulocytes, systemic immune-inflammation index and glycemia. The results suggested that a lower admission D-dimer could indicate an improved day 90 FO of patients with sICH, while also anticipating the development of PHE growth and ENW.

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Section: Resultsmentioning

confidence: 99%

Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study

et al. 2022

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“…Unsurprisingly, D-Dimer has been found to be associated with hemorrhage in prior studies. [7] Recent studies in the non-pregnant population have also found elevated D-Dimer, fibrinogen, and fibrinogen degradation product values among patients infected with SARS-CoV-2, along with decreased anti-thrombin levels, and have found these abnormalities to have prognostic value on mortality among patients infected with SARS-CoV-2. [8] There may exist a spectrum upon which abnormal bleeding will present depending upon the severity of the COVID infection, particularly in relation to abnormal COVID laboratory markers.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative coagulopathy during cesarean section as an unsuspected initial presentation of COVID-19: a case report

Kinsey

Ganz

Khalil

et al. 2020

BMC Pregnancy Childbirth

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Background: The world's understanding of COVID-19 continues to evolve as the scientific community discovers unique presentations of this disease. This case report depicts an unexpected intraoperative coagulopathy during a cesarean section in an otherwise asymptomatic patient who was later found to have COVID-19. This case suggests that there may be a higher risk for intrapartum bleeding in the pregnant, largely asymptomatic COVID-positive patient with more abnormal COVID laboratory values. Case: The case patient displayed D-Dimer elevations beyond what is typically observed among this hospital's COVID-positive peripartum population and displayed significantly more oozing than expected intraoperatively, despite normal prothrombin time, international normalized ratio, fibrinogen, and platelets. Conclusion: There is little published evidence on the association between D-Dimer and coagulopathy among the pregnant population infected with SARS-CoV-2. This case report contributes to the growing body of evidence on the effects of COVID-19 in pregnancy. A clinical picture concerning for intraoperative coagulopathy may be associated with SARS-CoV-2 infection during cesarean sections, and abnormal COVID laboratory tests, particularly D-Dimer, may help identify the patients in which this presentation occurs.

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“…Unsurprisingly, D-Dimer has been found to be associated with hemorrhage in prior studies. (7) Recent studies have also found elevated D-Dimer, brinogen, and brinogen degradation product values among patients infected with SARS-CoV-2, along with decreased anti-thrombin levels, and have found these abnormalities to have prognostic value on mortality among patients infected with SARS-CoV-2. (8) There may exist a spectrum upon which abnormal bleeding will present depending upon the severity of the COVID infection, particularly in relation to abnormal COVID laboratory markers.…”

Section: Case Presentationmentioning

confidence: 99%

Intraoperative Coagulopathy During Cesarean Section as an Unsuspected Initial Presentation of COVID-19: A Case Report

Kinsey

Ganz

Khalil

et al. 2020

Preprint

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Background: The world’s understanding of COVID-19 continues to evolve as the scientific community discovers unique presentations of this disease. This case report depicts an unexpected intraoperative coagulopathy during cesarean section in an otherwise asymptomatic patient who was later found to have COVID-19. This case suggests that there may be a higher risk for intrapartum bleeding in the pregnant, largely asymptomatic COVID-positive patient with more abnormal COVID laboratory values.Case: The case patient displayed D-Dimer elevations beyond what is typically observed among this hospital’s COVID-positive peripartum population and displayed significantly more oozing than expected intraoperatively, despite normal prothrombin time, international normalized ratio, fibrinogen, and platelets.Conclusion: There is little published evidence on the association between D-Dimer and coagulopathy among the pregnant population infected with SARS-CoV-2. This case report contributes to the growing body of evidence on the effects of COVID-19 in pregnancy. A clinical picture concerning for intraoperative coagulopathy may be associated with SARS-CoV-2 infection during cesarean sections, and abnormal COVID laboratory tests, particularly D-Dimer, may help identify the patients in which this presentation occurs.

show abstract

Plasma D-Dimer Concentrations and Risk of Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Cited by 17 publications

References 43 publications

Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study

Emergency department point‑of‑care biomarkers and day 90 functional outcome in spontaneous intracerebral hemorrhage: A single‑center pilot study

Intraoperative coagulopathy during cesarean section as an unsuspected initial presentation of COVID-19: a case report

Intraoperative Coagulopathy During Cesarean Section as an Unsuspected Initial Presentation of COVID-19: A Case Report

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