Plasma dehydroepiandrosterone, its sulfate, testosterone and FSH during puberty of african children in gabon

Mavoungou, D.; Gass, Ricardo; Emane, Moise N’Guema; Cooper, Robert L.; Roth-Meyer, C.

doi:10.1016/0022-4731(86)90132-9

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…Our finding of higher DHEA levels in girls than in boys and of their rapid rise after 10 years of age extends the observations of others (Sizonenko & Paunier 1975, De Peretti & Forest 1976, Mavoungou et al 1986, Maruyama et al 1987). Our finding of higher DHEA levels in girls than in boys and of their rapid rise after 10 years of age extends the observations of others (Sizonenko & Paunier 1975, De Peretti & Forest 1976, Mavoungou et al 1986, Maruyama et al 1987).…”

Section: Discussionsupporting

confidence: 91%

Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects

Šulcová

Hill²,

Hampl³

et al. 1997

Journal of Endocrinology

286

138

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Dehydroepiandrosterone sulphate (DHEAS) and unconjugated dehydroepiandrosterone (DHEA) have been determined in the blood serum of normal subjects of both sexes from 1 month to 100 years of age. In total, 92 girls, 49 boys, 211 women and 110 men were investigated. The effects of age and sex on the levels of the hormones were measured. DHEAS levels declined rapidly during the first year of life and were maintained at a minimum level for 5 years. They increased significantly from 6 to 7 years of age and reached maximum levels in women at about 24 years and in men at about 30 years of age. They then declined rapidly in both sexes but the fall which occurred after 50 and 60 years of age respectively was only moderate. Age-related unconjugated DHEA levels were different. After the first month of life DHEA levels were relatively high and declined more slowly. The minimum level was observed in girls between 5 and 7 years and in boys between 5 and 9 years of age. A significant rise then began and levels reached a maximum in women as well as in men at about 20 years of age. In men levels then declined up to the age of 80. In women the DHEA levels declined during the next 15 years and from approximately 36 years of age they again rose significantly up to a second peak. A mild but significant decline then resumed. There was a difference in the levels of DHEA and DHEAS depending on sex. Unlike DHEAS, unconjugated DHEA was higher in women than in men. However, this difference was significant only in some age groups: during puberty (between 11 and 15 years of age), in the premenopausal period (between 36 and 45 years of age) and in the older group (after 60 years of age). Age- and sex-related dependencies were different between DHEAS and DHEA. They indicate the possible variable secretion and dynamics of their (inter)conversion. We have concluded that DHEA measurements cannot be a substitute for DHEAS and vice versa.

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Section: Discussionsupporting

confidence: 91%

Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects

Šulcová

Hill²,

Hampl³

et al. 1997

Journal of Endocrinology

286

138

View full text Add to dashboard Cite

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“…Campbell et al (2004) reported a mean age of pubertal onset of 11.2 and 12.4 years for urban and rural Tonga boys from Zambia, based on an increase in testicular volume from 3 to 4 ml. Boys in Gabon show pubertal onset at 12 years, based on an initial rise in T and follicle-stimulating hormone (FSH) (Mavoungou et al, 1986). Only Tswana boys, with an average age of pubertal onset of 14.95 years, come close to our estimate for the Turkana Fig.…”

Section: Pubertal Timingsupporting

confidence: 63%

Pubertal timing, hormones, and body composition among adolescent Turkana males

Leslie

Little

Campbell

2005

American J Phys Anthropol

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The Turkana, like other East African pastoral groups, are known for their tall adult stature, achieved despite a blunted growth spurt during adolescence and continued growth into the early 20s. To investigate the hormonal mechanisms associated with the pattern of slow and continued adolescent growth, we collected data on hormonal status, height, weight, and trunk skinfolds and ethnographic self-reports of testicular maturation in a cross-sectional sample of 35 nomadic and 37 settled Turkana males aged 14-24. Hormonal determinations included testosterone (T), sex hormone-binding globulin (SHBG), and dehydroepiandrosterone (DHEA) in blood, in addition to urinary DHEA. Self-reports of testicular maturation showed no difference between settled and nomadic subpopulations. However, nomadic boys exhibited significantly higher levels of T, DHEA, and SHBG. Of all the hormones, only SHBG showed a significant relationship with age. Multiple regression models show blood T and SHBG to be significant independent predictors of achieved height as well as weight, controlling for age. Our results suggest that onset of puberty is substantially delayed among Turkana males, and that bioavailable T is related to growth in stature during adolescence. We suggest that SHBG acts to mediate the effects of energy availability on adolescent growth in this energetically limited population. Our findings may also have implications for understanding adolescent growth among Homo erectus.

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“…Estradiol and prostaglandin concentrations were determined with specific antibodies according to the method of Lee and Migeon (1975). Testosterone concentrations were measured by radioimmunoassay as previously reported (Mavoungou et al. 1986).…”

Section: Study Subjects and Methodsmentioning

confidence: 99%

“…We found that the prolactin concentration was significantly higher and that the human chorionic gonadotropin (HCG), testosterone, estradiol and luteinizing hormone (LH) concentrations were significantly lower in plasma samples from microfilaremic women than in plasma samples from amicrofilaremic women. Since we previously demonstrated that sex steroids were lower and prolactin levels were higher in infected women (Mavoungou et al. 1986,1989), we hypothesize that reduced concentrations of estradiol, which is a potent anti‐inflammatory, may cause increased production of pro‐inflammatory cytokines, which in turn may increase levels of prolactin.…”

Section: Introductionmentioning

confidence: 98%

Hypothalamic‐pituitary gonadal axis and immune response imbalance during chronic filarial infections

Mavoungou¹,

Poaty‐Mavoungou

Ongali³

et al. 2005

Tropical Med Int Health

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SummaryBi-directional relationships operate between the hypothalamic-pituitary-gonadal axis and the immune system. Cytokines, peptide hormones and their shared receptors/ligands are used as a common biological language for communication within and between the immune and neuroendocrine systems. Such communication suggests an immunoregulatory role for the brain and a sensory function for the immune system. We used a radioimmunoassay to measure the concentrations of steroid hormones (cortisol, testosterone, estradiol and progesterone) and pituitary hormones [follicle stimulating hormone (FSH), luteinizing hormone (LH) human chorionic gonadotropin (HCG) and prolactin] in peripheral blood plasma from 78 young Gabonese women with chronic filarial infections. We used an enzyme-linked immunosorbent assay to determine the concentrations of four proinflammatory cytokines [tumor necrosis factor-alpha (TNF-a), gamma interferon (IFN-c), interleukin-1 (IL-1) and IL-6] in the same plasma samples. Progesterone was unchanged and all other steroid hormone plasma concentrations were lower in microfilaremic women than in amicrofilaremic women. The concentration of LH was higher in amicrofilaremic women, whereas the prolactin concentration was higher in microfilaremics. The plasma concentrations of TNF-a, IFN-c, IL-1 and IL-6 were higher in microfilaremic women. A strong negative correlation was found between the steroid and pituitary hormones and the pro-inflammatory cytokines. Conversely, a strong positive correlation was found between prolactin and the same cytokines. These data provide first evidence of immune system and hormonal system disturbance during chronic filarial infections and suggest that the observed imbalance should be taken into account in the diagnosis and treatment of filarial infections.

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Plasma dehydroepiandrosterone, its sulfate, testosterone and FSH during puberty of african children in gabon

Cited by 9 publications

References 20 publications

Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects

Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects

Pubertal timing, hormones, and body composition among adolescent Turkana males

Hypothalamic‐pituitary gonadal axis and immune response imbalance during chronic filarial infections

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