Plasma Enhanced Hydrophobicity of Parylene-C Surfaces for a Blood Contacting Pressure Sensor

Brancato, Luigi; Keulemans, Grim; Gijsenbergh, Pieter; Puers, Robert

doi:10.1016/j.proeng.2014.11.751

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…For instance, bovine serum albumin (BSA) adsorbs more easily on highly hydrophobic substrates, decreasing the blood flow velocity. 58 To optimize the surface properties, the influence of oxygen plasma treatment on the surface energy was investigated. Without oxygen plasma treatment, blood got stuck at the inlet, not advancing further into the micro-channels (see Figure S.2 in supplementary material).…”

Section: Blood Flow Velocitymentioning

confidence: 99%

Printed microfluidic filter for heparinized blood

et al. 2017

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A simple lab-on-a-chip method for blood plasma separation was developed by combining stereolithographic 3D printing with inkjet printing, creating a completely sealed microfluidic device. In some approaches, one dilutes the blood sample before separation, reducing the concentration of a target analyte and increasing a contamination risk. In this work, a single drop (8 l) of heparinized whole blood could be efficiently filtered using a capillary effect without any external driving forces and without dilution. The blood storage in heparin tubes during 24 h at 4 °C initiated the formation of small crystals that formed auto-filtration structures in the sample upon entering the 3D-printed device, with pores smaller than the red blood cells, separating plasma from the cellular content. The total filtration process took less than 10 s. The presented printed plasma filtration microfluidics fabricated with a rapid prototyping approach is a miniaturized, fast and easy-to-operate device that can be integrated into healthcare/portable systems for point-of-care diagnostics.

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Section: Blood Flow Velocitymentioning

confidence: 99%

Printed microfluidic filter for heparinized blood

et al. 2017

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“…In a different configuration of the top plates, the Teflon layer is replaced by a 3 μm thick layer of Parylene-C, treated with RIE to make it more hydrophobic [19]. A Parylene-C layer has the advantage of giving a rough surface, improving the pinning effect of the gaps.…”

Section: Fabrication Of the Top Platementioning

confidence: 99%

Towards an electrowetting-driven microconveyor: an investigation of the load-dependent droplet shape

Geukens

Reynaerts

Puers

2016

J. Micromech. Microeng.

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In this paper, we investigate the possibilities of using water droplets to support and move a platform, making use of the principle of electrowetting. A new way for making micro-conveyors is thereby developed. The most important element in designing such a micro-conveyor system is the load that it can carry. This paper focuses on the static part, and describes a theoretical model that defines the relationship between the applied load and shape of the supporting droplets. An experimental validation is given, showing good correspondence to the model. Furthermore, experiments regarding an optimal design of the platform are discussed.

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“…Hydrophilic Parylene-C coatings have been fabricated by O 2 and air plasma treatment for anchoring drugs [17], or for improving cells adhesion in cell-based microdevices [14]. Super-hydrophobic Parylene-C layers have been successfully realized by consecutively exposing the polymer to low-power O 2 and SF 6 plasma [18,19]. This paper investigates the effects of plasma-induced nanostructuring of Parylene-C on its performance as an encapsulation material for blood contacting implants.…”

Section: Introductionmentioning

confidence: 99%

Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

et al. 2018

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This paper investigates the effects on the blood compatibility of surface nanostructuring of Parylene-C coating. The proposed technique, based on the consecutive use of O2 and SF6 plasma, alters the surface roughness and enhances the intrinsic hydrophobicity of Parylene-C. The degree of hydrophobicity of the prepared surface can be precisely controlled by opportunely adjusting the plasma exposure times. Static contact angle measurements, performed on treated Parylene-C, showed a maximum contact angle of 158°. The nanostructured Parylene-C retained its hydrophobicity up to 45 days, when stored in a dry environment. Storing the samples in a body-mimicking solution caused the contact angle to progressively decrease. However, at the end of the measurement, the plasma treated surfaces still exhibited a higher hydrophobicity than the untreated counterparts. The proposed treatment improved the performance of the polymer as a water diffusion barrier in a body simulating environment. Modifying the nanotopography of the polymer influences the adsorption of different blood plasma proteins. The adsorption of albumin—a platelet adhesion inhibitor—and of fibrinogen—a platelet adhesion promoter—was studied by fluorescence microscopy. The adsorption capacity increased monotonically with increasing hydrophobicity for both studied proteins. The effect on albumin adsorption was considerably higher than on fibrinogen. Study of the proteins simultaneous adsorption showed that the albumin to fibrinogen adsorbed ratio increases with substrate hydrophobicity, suggesting lower thrombogenicity of the nanostructured surfaces. Animal experiments proved that the treated surfaces did not trigger any blood clot or thrombus formation when directly exposed to the arterial blood flow. The findings above, together with the exceptional mechanical and insulation properties of Parylene-C, support its use for packaging implants chronically exposed to the blood flow.

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Plasma Enhanced Hydrophobicity of Parylene-C Surfaces for a Blood Contacting Pressure Sensor

Cited by 8 publications

References 5 publications

Printed microfluidic filter for heparinized blood

Printed microfluidic filter for heparinized blood

Towards an electrowetting-driven microconveyor: an investigation of the load-dependent droplet shape

Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

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