Plasma enhanced label-free immunoassay for alpha-fetoprotein based on a U-bend fiber-optic LSPR biosensor

Liang, Gaoling; Zhao, Zhongjun; Yin, Wei; Liu, Kunping; Hou, Wenqian; Duan, Yun

doi:10.1039/c5ra02910d

Cited by 55 publications

(17 citation statements)

References 42 publications

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“…In reflection based fiber-optic sensor using gold nanoparticles, sensitivity of 195.72 nm/RIU has been reported [32]. Recently, RI sensitivity of 20.25 ΔA/RI was reported using plasma treated u-bent LSPR fiber optic probes [33]. In another configuration involving AuNP functionalized straight fiber probes, sensitivity of 4.21ΔA/RI was achieved [34].…”

Section: Sugar Monitoring In Packaged Juicesmentioning

confidence: 96%

A silicon nitride coated LSPR based fiber-optic probe for possible continuous monitoring of sucrose content in fruit juices

Chauhan

Punjabi

Sharma

et al. 2016

Sensors and Actuators B: Chemical

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Section: Sugar Monitoring In Packaged Juicesmentioning

confidence: 96%

A silicon nitride coated LSPR based fiber-optic probe for possible continuous monitoring of sucrose content in fruit juices

Chauhan

Punjabi

Sharma

et al. 2016

Sensors and Actuators B: Chemical

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“…Origami also provides new routes to guide light inside microstructures for biosensing. For example, manual or machine‐assisted bending of optical fibers can be used to form a u‐shaped structure that presents a larger evanescent field at the folded region due to scattering of light . Thus, the transmitted light at the other end of the fiber is influenced by the absorption of light from analytes near the surfaces of the fiber at its u‐shaped section and can be utilized for sensitive biosensing.…”

Section: Origami Biosensorsmentioning

confidence: 99%

“…The additional inclusion of noble metal nanoparticles can further enhance sensitivity. With this combined approach, Sai et al have found a tenfold improved absorption after coating a bent fiber with a monolayer of gold nanoparticles and could be used to detect sucrose solutions, protein antibodies (anti‐Human Immunoglobulin G) via complementary bioreceptors, alpha‐fetoprotein, and Escherichia coli bacteria …”

Section: Origami Biosensorsmentioning

confidence: 99%

Origami Biosystems: 3D Assembly Methods for Biomedical Applications

et al. 2018

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Conventional assembly of biosystems has relied on bottom‐up techniques, such as directed aggregation, or top‐down techniques, such as layer‐by‐layer integration, using advanced lithographic and additive manufacturing processes. However, these methods often fail to mimic the complex three dimensional (3D) microstructure of naturally occurring biomachinery, cells, and organisms regarding assembly throughput, precision, material heterogeneity, and resolution. Pop‐up, buckling, and self‐folding methods, reminiscent of paper origami, allow the high‐throughput assembly of static or reconfigurable biosystems of relevance to biosensors, biomicrofluidics, cell and tissue engineering, drug delivery, and minimally invasive surgery. The universal principle in these assembly methods is the engineering of intrinsic or extrinsic forces to cause local or global shape changes via bending, curving, or folding resulting in the final 3D structure. The forces can result from stresses that are engineered either during or applied externally after synthesis or fabrication. The methods facilitate the high‐throughput assembly of biosystems in simultaneously micro or nanopatterned and layered geometries that can be challenging if not impossible to assemble by alternate methods. The authors classify methods based on length scale and biologically relevant applications; examples of significant advances and future challenges are highlighted.

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“…When confined to a metallic nanostructure or nanoparticle are mentioned as localized surface plasmons (LSP) [8]. In this regard, Localized Surface Plasmon Resonance (LSPR) became a subject of great interest in research due to the multitude of applications that arise from this phenomenon [9,10]. Aside from decorative purposes, many technological applications of LSPR can be found in the literature, such as plasmonic sensors for gas and biomolecular detection, plasmon based photo-detectors, phototherapies and surface enhanced Raman spectroscopy (SERS) [11,12].…”

Section: Introductionmentioning

confidence: 99%

Development of biocompatible plasmonic thin films composed of noble metal nanoparticles embedded in a dielectric matrix to enhance Raman signals

Costa

Oliveira

Rodrigues

et al. 2019

Applied Surface Science

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This work focused on the production of nanocomposite thin films, composed of noble nanoparticles embedded in a dielectric matrix, to be tested as biocompatible plasmonic platforms for detection of molecules using Surface Enhance Raman Spectroscopy (SERS). Three different thin films systems were deposited by reactive DC magnetron sputtering, namely Au-Al2O3, Au-TiO2 and Ag-TiO2. The depositions were followed by a thermal treatment at different temperatures to promote the growth of the nanoparticles. Localized Surface Plasmon Resonance (LSPR) bands appeared already at 300 ºC, related to the presence of Au nanoparticles, and at 500 ºC in the case of Ag nanoparticles. Furthermore, at 700º C, the Ag-TiO2 films showed a broadband optical response due to the formation of Ag clusters at the film's surface. The biological experiments showed that the presence of the thin films didn't affect the growth of C. albicans, which is very convenient if one needs to detect low concentrations of this microorganism using SERS platforms. As for the SERS 2 measurements, an enhancement of R6G Raman spectra intensity was clearly perceivable, but only for the TiO2 matrix. Furthermore, the application of a plasma treatment allowed to better expose the nanoparticles, providing a further enhancement of Raman signals.

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Plasma enhanced label-free immunoassay for alpha-fetoprotein based on a U-bend fiber-optic LSPR biosensor

Abstract: A simple, label-free and cost-effective localized surface plasmon resonance (LSPR) immunosensing method was developed for detection of alpha-fetoprotein (AFP).

Cited by 55 publications

References 42 publications

A silicon nitride coated LSPR based fiber-optic probe for possible continuous monitoring of sucrose content in fruit juices

A silicon nitride coated LSPR based fiber-optic probe for possible continuous monitoring of sucrose content in fruit juices

Origami Biosystems: 3D Assembly Methods for Biomedical Applications

Development of biocompatible plasmonic thin films composed of noble metal nanoparticles embedded in a dielectric matrix to enhance Raman signals

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