Plasma exchange and selective adsorption in Guillain-Barré syndrome—a comparison of therapies by clinical course and side effects

Rosenow, Felix; Haupt, Walter F.; Grieb, P; Jiménez-Klingberg, C.; Borberg, H.

doi:10.1016/0955-3886(93)90047-x

Cited by 18 publications

(9 citation statements)

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“…In the first step, we compared the plasma treatment groups (PE and SA). Clinical course and side effects were similar in both groups as shown by a preliminary investigation (15). Statistical evaluation of the plasma treatment subgroup (11 PE and 13 SA patients) showed no statistically significant differences with respect to the clinical course.…”

Section: Resultssupporting

confidence: 64%

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Sequential Treatment of Guillain‐Barré Syndrome with Extracorporeal Elimination and Intravenous Immunoglobulin

Haupt

Rosenow

Ven

et al. 1997

Therapeutic Apheresis

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Plasma exchange and administration of intravenous immunoglobulin (IgG) are established treatments for Guillain-Barré syndrome (GBS). Elimination of postulated pathogenetic factors by plasma exchange or selective adsorption treatment using affinity-type adsorption columns and subsequent immunomodulation by intravenous IgG may provide a more effective treatment. Forty-five patients with acute GBS were prospectively examined using a clinical score. We treated 11 patients by plasma exchange, 13 patients by selective adsorption using a tryptophan-linked polyvinyl alcohol gel adsorbent, and 21 patients by selective adsorption followed by intravenous IgG. The patients treated sequentially by selective adsorption and intravenous IgG improved significantly better than the patients who received plasma treatment only. The results suggest that sequential treatment of GBS may be superior to plasma treatment alone. The higher cost of combined treatment may be offset by lower overall expenditure.

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Section: Resultssupporting

confidence: 64%

“…It has been used successfully in myasthenia gravis (12,13) and may be preferable to PE because it obviates the administration of human albumin. In our experience, PE and SA have shown equally favorable results in acute GBS (15). Intravenous IgG treatment has been successful in various immunological diseases (16,17) as well as in GBS (2,3,6).…”

Section: Discussionmentioning

confidence: 75%

Sequential Treatment of Guillain‐Barré Syndrome with Extracorporeal Elimination and Intravenous Immunoglobulin

Haupt

Rosenow

Ven

et al. 1997

Therapeutic Apheresis

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“…selective extracorporeal adsorption) has been used as an alternative to plasma exchange in Japan, Germany, and other countries. Initial observations have shown a positive effect of immune adsorption in the treatment of GBS patients [3] and also that immune adsorption might be at least as efficacious as and safer than plasma exchange. However, no controlled studies in GBS have been performed.…”

mentioning

confidence: 99%

A Preliminary, Randomized, Multicenter Study Comparing Intravenous Immunoglobulin, Plasma Exchange, and Immune Adsorption in Guillain-Barré Syndrome

et al. 2001

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“…In the first step, we compared the plasma treatment groups (PE and SA). Clinical course and side effects were comparable in both groups as shown by preliminary investigations (14,17). Statistical evaluation of the plasma treatment subgroup (11 PE and 13 SA patients) showed no statistically significant differences with respect to the clinical course (Table 1).…”

Section: Resultsmentioning

confidence: 55%

Apheresis and Selective Adsorption Plus Immunoglobulin Treatment in Guillain‐Barré Syndrome

Haupt

Birkmann

Ven

et al. 2000

Therapeutic Apheresis

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Plasma exchange (PE) and administration of intravenous immunoglobulin (i.v. IgG) are established treatments for Guillain-Barré syndrome (GBS). Combination treatment with elimination of postulated pathogenetic factors by PE or selective adsorption (SA) treatment and subsequent immunomodulation by intravenous IgG may provide a more effective treatment. In a single-center randomized study, 45 patients with acute GBS were prospectively examined using a clinical score. We treated 11 patients by PE, 13 with SA using a tryptophan-linked polyvinyl alcohol gel adsorbent, and 21 with SA followed by intravenous IgG. The patients treated sequentially by selective adsorption and intravenous IgG improved significantly better than the patients who received plasma treatment only. The results suggest that combination treatment of GBS may be superior to plasma treatment alone.

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Plasma exchange and selective adsorption in Guillain-Barré syndrome—a comparison of therapies by clinical course and side effects

Cited by 18 publications

References 1 publication

Sequential Treatment of Guillain‐Barré Syndrome with Extracorporeal Elimination and Intravenous Immunoglobulin

Sequential Treatment of Guillain‐Barré Syndrome with Extracorporeal Elimination and Intravenous Immunoglobulin

A Preliminary, Randomized, Multicenter Study Comparing Intravenous Immunoglobulin, Plasma Exchange, and Immune Adsorption in Guillain-Barré Syndrome

Apheresis and Selective Adsorption Plus Immunoglobulin Treatment in Guillain‐Barré Syndrome

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