Plasma exogenous creatinine clearance in clinically healthy cats: Comparison with urinary exogenous creatinine clearance, tentative reference intervals and indexation to bodyweight

Reynolds, Brice S; Massal, Marc; Nguyen, Patrick; Grégoire, L.L.; Périgaud, A.E.; Concordet, Didier; Biourge, Vincent; Lefebvre, Henri

doi:10.1016/j.tvjl.2014.07.022

Cited by 2 publications

(1 citation statement)

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“…Additionally, the creatinine level is influenced by factors such as muscle mass, diet, and exercise. It has been proven that creatinine is poorly correlated with GFR values obtained by golden methods [ 20 , 25 ].…”

Section: Utilizing Plasma Levels Of Endogenous Markers To Evaluate Gfrmentioning

confidence: 99%

Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals

Yang

2022

Kidney Dis

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Background: The glomerular filtration rate (GFR), as the benchmark of renal function, has been widely used in clinical practice and basic medical research. Currently, most researchers still rely on endogenous markers, such as plasma creatinine, blood urea nitrogen, and cystatin C, to evaluate renal function in laboratory animals. While inexpensive and simple to use, methods based on endogenous markers are often inaccurate and susceptible to several internal physiological factors. Thus, it is necessary to establish a method to precisely assess the GFR, especially when detecting early changes in GFR during acute kidney injury, and hyperfiltration usually caused by pregnancy or diabetic nephropathy. In addition, laboratory animals have higher tolerance for invasive procedures than humans, allowing novel technologies to be applied on them for GFR monitoring. In recent years, significant progress has been made in developing new methods to assess GFR in animals. However, no publication has reviewed these techniques. Summary: This article summarized the majority of methods used to assess the GFR in animals in recent decades and discussed their working principles, workflows, advantages, and limitations, providing a wealth of reference and information for researchers interested in studying the kidney function in animals and developing techniques to monitor the GFR.

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Section: Utilizing Plasma Levels Of Endogenous Markers To Evaluate Gfrmentioning

confidence: 99%

Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals

Yang

2022

Kidney Dis

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Tikhonov gamma variate adaptive regularization applied to technetium Tc 99m diethylenetriamine pentaacetic acid plasma clearance, compared with three other methods, for measuring glomerular filtration rate in cats

Snead

Milo

McCrea

et al. 2019

ajvr

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OBJECTIVE To evaluate agreement of 4 methods (Tikhonov gamma variate adaptive regularization of plasma concentration-time curve fitting applied to technetium Tc 99m diethylenetriamine pentaacetic acid [99mTc-DTPA] plasma clearance [Tk-GV], plasma clearance of exogenous creatinine [CrCL], Gates gamma camera-based measurement method with 99mTc-DTPA renal clearance and dynamic scintigraphy [GTS], and iohexol renal clearance assessed with dynamic CT with Patlak plotting [CT-Pp]) for measuring glomerular filtration rates (GFR) in healthy cats. ANIMALS 7 healthy, laboratory-raised cats. PROCEDURES Each method for measuring GFR was performed twice in 7 cats at 24-day intervals. The Wilcoxon signed-rank sum test was used to compare the results obtained from the 14 studies for each method. Results from the 4 methods were assessed for agreement and correlation. RESULTS The median GFR values were 2.75, 2.83, 3.14, and 4.26 mL/min/kg, for Tk-GV, CT-Pp, plasma CrCL, and GTS, respectively. Analysis with Wilcoxon signed-rank sum tests identified significant pairwise differences between results obtained with the Tk-GV versus the plasma CrCL method, the Tk-GV versus the GTS method, and the plasma CrCL versus the GTS method. The least variable method was Tk-GV, with an SD of 1.27 (mL/min/kg). CONCLUSIONS AND CLINICAL RELEVANCE Findings indicated that Tk-GV yielded GFR measurements comparable with those obtained with CT-Pp, plasma CrCL, and GTS; however, the Tk-GV method yielded the tightest range of results among the methods evaluated.

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Plasma exogenous creatinine clearance in clinically healthy cats: Comparison with urinary exogenous creatinine clearance, tentative reference intervals and indexation to bodyweight

Cited by 2 publications

References 42 publications

Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals

Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals

Tikhonov gamma variate adaptive regularization applied to technetium Tc 99m diethylenetriamine pentaacetic acid plasma clearance, compared with three other methods, for measuring glomerular filtration rate in cats

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