Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study

Tiemeier, Henning; Tuijl, H. Ruud van; Hofman, Albert; Kiliaan, Amanda J.; Breteler, Monique M.B.

doi:10.1093/ajcn/78.1.40

Cited by 244 publications

(148 citation statements)

References 34 publications

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“…The participants' characteristics are summarized in Table 1. The scores (mean7SD) on the eight scales of the SF-36 were [8,32]. Table 2 shows the results of the hierarchical linear regression analyses.…”

Section: Resultsmentioning

confidence: 99%

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Fish consumption, not fatty acid status, is related to quality of life in a healthy population

Schiepers

Groot

Jolles

et al. 2010

Prostaglandins, Leukotrienes and Essential Fatty Acids

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a b s t r a c tDepressive symptoms in the community have a considerable impact on quality of life. Although longchain polyunsaturated fatty acids (LCPUFA) have frequently been implicated in depressed mood, their relationship with quality of life has scarcely been investigated.This study examined the cross-sectional associations between fish consumption and plasma phospholipid LCPUFA status on the one hand, and quality of life, as measured by the Short Form 36 questionnaire, on the other in a population-based sample. The mental health component of quality of life was not associated with LCPUFA status or fish consumption. Fish consumption showed a positive association with physical well-being, which remained significant after correction for LCPUFA status, suggesting that the relationship between fish consumption and physical well-being is independent of the LCPUFA content of fish. These findings indicate that fish consumption may serve as a proxy for a healthy lifestyle or a favorable nutritional status, which is reflected in better quality of life.

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Section: Resultsmentioning

confidence: 99%

“…It has often been suggested that long-chain polyunsaturated fatty acids (LCPUFA), which are primarily found in fish, may lower the risk of developing depressive symptoms [7][8][9]. Strikingly, the relationship between LCPUFA status and quality of life has scarcely been investigated-only one study has addressed this issue to date.…”

Section: Introductionmentioning

confidence: 99%

Fish consumption, not fatty acid status, is related to quality of life in a healthy population

Schiepers

Groot

Jolles

et al. 2010

Prostaglandins, Leukotrienes and Essential Fatty Acids

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show abstract

“…(1998) (63) C major depression (64) C major depression (65) C major depression (66) C and SC major depression (67) C major depression in ACS patients (68) C major depression in ACS patients (69) C depression in MI patients (70) C postpartum (71) C major depression (72) C major depression (74) NC adolescent depression (75) NC depression in lung cancer patients…”

Section: Trial Evidencementioning

confidence: 99%

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

2008

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Selected biochemical evidence suggests a potential role for n-3 long-chain PUFA (n-3PUFA) in the regulation of mood and behaviour. The present paper reviews the relevant evidence, to date, from epidemiological studies, clinical studies and intervention trials. Most evidence is available investigating a role for n-3PUFA in depression, depressive illness and suicidal behaviour, but work is also available on anxiety and anxiety-related disorders, fatigue and fatigue-related disorders, aggression, hostility and anti-social behaviour, inattention, impulsivity and attention deficit hyperactivity disorder and schizophrenic disorders. For all these aspects of mood and behaviour, the evidence available is currently limited and highly inconsistent, both in terms of study methodology and study findings. There is a clear need for further work in this area.

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“…Many studies have found lower LCn3PUFA levels in erythrocyte membranes [28], total serum [29], plasma [43] and plasma phospholipids [30,44] in depressed patients and inverse relationships between these LCn3PUFA biomarkers and depression status, while others have found no such relationships [42,[45][46][47]. These discrepancies may be due to differing demographic characteristics of the samples evaluated (including severity of depressive symptoms), type of cardiovascular disease, the method of depression measurement and the component of blood extracted for the assessment of LCn3PUFA content.…”

Section: Discussionmentioning

confidence: 99%

There is No Association Between the Omega-3 Index and Depressive Symptoms in Patients With Heart Disease Who Are Low Fish Consumers

Cai

Coates

Buckley

et al. 2017

Heart, Lung and Circulation

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Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study

Abstract: In community-dwelling persons, fatty acid composition is related to depression. Because this relation was not secondary to inflammation, atherosclerosis, or possible confounders, it suggests a direct effect of fatty acid composition on mood.

Cited by 244 publications

References 34 publications

Fish consumption, not fatty acid status, is related to quality of life in a healthy population

Fish consumption, not fatty acid status, is related to quality of life in a healthy population

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

There is No Association Between the Omega-3 Index and Depressive Symptoms in Patients With Heart Disease Who Are Low Fish Consumers

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