Plasma free and total iodothyronine levels in the newborn lamb. Physiological considerations

Cabello, Gérard; Wrutniak, Chantal

doi:10.1051/rnd:19860906

Cited by 9 publications

(10 citation statements)

References 14 publications

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“…There is a strong relationship between total and free hormonal fractions, indicating that the amount of total T 3 is a major determinant of free T 3 concentration (Cabello and Wrutniak, 1986) while the neonatal rise in free T 4 levels is more important than total T 4 levels as free T 4 is the direct substrate for T 3 production (Wrutniak and Cabello, 1987;Cabello and Wrutniak, 1989). The lower total and free T 3 levels suggest a decline in the peripheral T 4 to T 3 conversion in the I-3 lambs.…”

Section: Discussionmentioning

confidence: 99%

“…A positive relationship has been reported between BW and serum T 3 and T 4 concentrations in newborn lambs (Wrutniak and Cabello, 1987) and this most likely contributed to the higher thyroid hormone levels in the current study compared with those reported by Kececi (2003) where lamb BW was only 2.77 kg compared with 4.7 and 5.2 kg for C and I-3 lambs, respectively, in the current experiment. Also, contributing to the higher levels of thyroid hormones reported by Davicco et al (1982) would be later sampling time at 6 h post partum, as it has been reported that plasma thyroid hormone levels increase significantly during the first 8 h post partum following which, they decrease rapidly (Cabello and Wrutniak, 1986).…”

Section: Discussionmentioning

confidence: 99%

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The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T3 and T4 levels in the progeny

Boland

Hayes

Sweeney

et al. 2008

Animal

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Sixty twin-bearing ewes were allocated to one of four dietary treatments investigating the effects of supplementary iodine or cobalt during late pregnancy on lamb serum immunoglobulin G (IgG), triiodothyronine (T 3 ), thyroxine (T 4 ) and vitamin E concentrations, and lamb IgG absorption efficiency. Ewes were offered grass silage ad libitum supplemented with 800 g per ewe per day of a 190 g/kg crude protein (CP) concentrate from day 126 of gestation until parturition plus one of the following supplements (n 5 15 per treatment); no supplement (C); 26.6 mg iodine per day for final 3 weeks pre partum (I-3); 26.6 mg iodine/day for final week pre partum (I-1); 20 mg cobalt/day for final 3 weeks pre partum (Co-3). Lambs were blood sampled at 24 and 72 h post partum for serum IgG and vitamin E concentrations. Ten lambs from C and I-3 were blood sampled at 1 h post partum for serum IgG, vitamin E, T 3 and T 4 concentrations. There were no differences in serum IgG, vitamin E or T 4 values (P . 0.05) at 1 h post partum between lambs born to the C and I-3 ewes. T 3 levels were lower in I-3 compared with C progeny (P , 0.05). Supplemental iodine reduced colostral IgG absorption efficiency (P , 0.001) and lamb serum IgG concentrations at 24 and 72 h post partum (P , 0.001). Serum vitamin E concentration in I-3 and I-1 lambs was lower than in Co-3 lambs at 24 h post partum, while at 72 h post partum I-3, I-1 and Co-3 lambs had significantly lower concentrations than C lambs (P , 0.001). Supplementing the ewe's diet with 26.6 mg/day of iodine for the final week of pregnancy reduced lamb serum IgG concentration at 24 and 72 h post partum. The lower total and free T 3 values in the progeny of I-3-treated ewes suggest interference in the synthesis and metabolism of thyroid hormones when ewes receive excessive dietary iodine for 3 weeks immediately pre partum. Based on these findings, the indications are that the toxicity level for iodine in the diet of the pregnant ewe should be lowered to 20 mg per ewe per day, equivalent to 40% of its current level. The finding that high-level cobalt supplementation during the final 3 weeks of pregnancy will have a negative effect on serum vitamin E concentration at 72 h post partum is a new and significant finding and previously has not been reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T3 and T4 levels in the progeny

Boland

Hayes

Sweeney

et al. 2008

Animal

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“…Lastly, it appears that a decrease in blood pH could slightly reduce the proportion and the amount of circulating free T4, probably by affecting the affinity of carrier proteins for T4; however, as these levels were not clearly influenced by the progressive restoration of blood pH, the physiological rise in blood pH occurring over the first 16 h of life is probably not the major factor involved in the increasing FT4/T4 ratio recorded after birth (Cabello, 1987;Cabello & Wrutniak, 1986, 1988.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown in the lamb, that the neonatal rise in free T4 (FT4) levels was more important and that its duration was longer than the increase in plasma total T4 levels (Cabello, 1987;Cabello & Wrutniak, 1986, 1988. As FT4 is the direct substrate for cell triiodothyronine (T3) production, such a phenomenon is probably important for the establishement of neonatal thyroid function.…”

Section: Introductionmentioning

confidence: 99%

Influence of experimental acidosis on the concentrations of thyreostimulin (TSH) and iodothyronines (total T4, free T4, T3) in the plasma of the newborn lamb

Cabello¹,

Wrutniak²

1989

Reprod. Nutr. Dévelop.

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“…Bearing in mind the fact that thyroid hormones play an important role in the maturation of the foetus (Cabello and Wrutniak, 1986) they have been often studied. Thyroxin (T4) has a depressive effect on Ig absorption.…”

Section: Animal Factorsmentioning

confidence: 99%

Acquisition of passive immunity in domestic ungulates

Grongnet¹,

Duvaux-Ponter

1998

J. Anim. Feed Sci.

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The ungulates possess an epteriochondrial placenta, which separates the maternal and foetal blood systems and thus reduces the permeability of the placenta to small molecules. Thus, in these species, the colostral imminoglobulins are the main source of protection factors which aid survival in the first days of life. This review deals with several aspects of passive immunity in ungulate neonates: the type and the origin of colostral immunoglobulins and factors which influence their production in the mother and their absorption form the gastrointestinal tract of the neonate.Recommendations for farmes to enhance natural postnatal immunity and recent technological advances in the production of immunoglobulin preparations are discussed.

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Plasma free and total iodothyronine levels in the newborn lamb. Physiological considerations

Abstract: Summary. Neonatal Introduction.

Cited by 9 publications

References 14 publications

The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T3 and T4 levels in the progeny

The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T3 and T4 levels in the progeny

Influence of experimental acidosis on the concentrations of thyreostimulin (TSH) and iodothyronines (total T4, free T4, T3) in the plasma of the newborn lamb

Acquisition of passive immunity in domestic ungulates

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