Plasma ghrelin levels in patients undergoing haemodialysis and peritoneal dialysis

Abstract

PGhr levels were moderately and similarly increased in patients undergoing HD and PD. Age was a strong determinant of PGhr levels, both in uraemic patients and in healthy controls. Dialysis adequacy, residual renal function and inflammation did not appear to influence ghrelin levels in these patients. The negative correlation between PGhr and nutritional markers suggests that low dietary intake causes increases in ghrelin secretion in dialysis patients.

Subcutaneous Ghrelin Enhances Acute Food Intake in Malnourished Patients Who Receive Maintenance Peritoneal Dialysis

“…We demonstrated elevated endogenous total ghrelin levels in this cohort of PD patients, compared with BMI-matched healthy individuals, in agreement with observations by Perez-Fontan et al (29) and Ayala et al (30). Although there are high endogenous levels of total ghrelin, dietary energy intake is paradoxically reduced in PD patients.…”

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

“…Increased total ghrelin has been reported to be associated with cachexia in chronic heart failure patients (Nagaya et al 2001). Increased total ghrelin levels are also reported in dialysis patients (Perez-Fontan et al 2004). There are two major forms of ghrelin-acylated and des-acylated.…”

Unacylated ghrelin and obestatin in pediatric CKD: are they important in protein energy wasting?

“…Although ghrelin is degraded in the kidney, its levels are not uniformly increased in CKD patients [15]. Some studies with dialysis patients have demonstrated elevated ghrelin levels, whereas other studies have shown normal or even low ghrelin levels in CKD patients [16,17]. A possible explanation for these seemingly contradicting findings is that only UAG levels were elevated in the CKD patients.…”