Plasma Ghrelin Levels in Various Stages of Development of Iron Deficiency Anemia

Akarsu, Saadet; Üstündağ, Bilal; Gürgöze, Metin Kaya; Şen, Yaşar; Aygün, A. Denizmen

doi:10.1097/mph.0b013e3180645170

Cited by 33 publications

(30 citation statements)

References 20 publications

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“…After iron supplementation, ghrelin concentration tended to be increased compared with their basal ghrelin concentrations. These results agree with the findings of İsguven et al [6] and with Akarsu et al, [7] who previously noted that total ghrelin was decreased in children with IDA. Like them, we also assumed that loss of appetite correlated with a decreased level of ghrelin in adult females with IDA.…”

Section: Discussionsupporting

confidence: 83%

“…But if iron levels are too low, the number of red blood cells and hemoglobin production falls below normal, resulting in IDA [1]. This anemia is also associated with some bioactive peptide hormonal changes [4,7]. In this study, both saliva and serum basal hormone acylated ghrelin concentrations in subjects with IDA were significantly lower levels when compared with the control group without IDA.…”

Section: Discussionmentioning

confidence: 74%

“…Further more recently, Isguven et al [6] and Akarsu et al [7] reported that total ghrelin decreased with IDA and concluded that appetite loss in iron deficiency is a result of decrement of appetite hormone ghrelin [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Further studies showed that obestatin was also involved in inhibiting thirst, improving memory, and affecting cell proliferation (reviewed [24]). As indicated above, ghrelin and obestatin might play crucial role or roles in a quite diverse range of physiologic functions in diseases, including IDA Since it has been shown that ghrelin decreased in children with IDA, it was concluded that loss of appetite was a result of decreased ghrelin [6,7]. However, both groups in those studies [6,7], they measured only total ghrelin in children with IDA and did not follow up by iron supplementation, whereas appetite stimulation could be achieved with acylated ghrelin [21].…”

Section: Introductionmentioning

confidence: 99%

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Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

Uğur

Aydın

Dönder

et al. 2018

Preprint

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Ghrelin and obestatin, two antagonist peptide hormones, are purportedly involved in stimulating appetite and controlling energy balance in humans. Serum ghrelin level is also associated with iron deficiency anemia (IDA), but no study has yet been made of the obestatin level in patients with IDA, even though both hormones are a single gene product. Therefore, the purpose of this investigation is to see whether there is a link between IDA and these two hormones among other hematological parameters in patients with IDA. To measure ghrelin and obestatin, human saliva and serum were collected from 30 women with IDA, aged 31.7 ± 10.7 years, and 30 control women, aged 30.2 ± 8.0 years, with repeated collection of samples over a period of 1 week and 1 month. Saliva and serum ghrelin levels were measured by ELISA. Serum hemoglobin, ferritin, hematocrit and total iron-binding capacity (TIBC) values were determined with an Olympus AU2700. Saliva and serum ghrelin and obestatin levels were significantly lower in the IDA group compared with controls; these levels increased slightly above baseline with iron treatment, but remained below the control values.Furthermore, and as expected, serum hemoglobin, ferritin, and hematocrit levels were 2 significantly increased with iron treatment, while total iron-binding capacity decreased compared to baseline concentrations. The findings suggest that IDA might be linked to imbalance of circulating (serum) and non-circulating (saliva) ghrelin and obestatin levels.Decreased ghrelin and obestatin might destroy iron homeostasis through its effect on intestinal absorption. Measuring these hormone levels might be useful for monitoring the response to iron treatment. Also, serum and saliva levels for both hormones were well correlated. Thus, using saliva in place of serum for monitoring the two hormones should minimize inconvenience and patient discomfort.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

Uğur

Aydın

Dönder

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…After identification of ghrelin in mammals by Kojima et al [2] so many relative studies were conducted on ghrelin properties. Studies conducted during last decade suggested various specifies and functions for ghrelin, such as GH-releasing [3] , osteogenesis [4,5] , hematopoiesis [6,7] , food intake and energy balance and regulation [8,9] , endocrine/ paracrine roles in pancreas [10,11] , and currently antioxidative effects [12,13] . Peptide structure of chicken ghrelin has 26 amino acids with 54% similarity to rat ghrelin [14] .…”

Section: Introductionmentioning

confidence: 99%

Effect of in ovo ghrelin administration on serum malondialdehyde level in newly-hatched chickens

Lotfi

Shahryar

Ebrahimnezhad

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Fasting up‐regulates ferroportin 1 expression via a Ghrelin/GHSR/MAPK signaling pathway

Luo

Zhou

Chen

et al. 2017

Journal Cellular Physiology

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The significant positive correlation between ghrelin and iron and hepcidin levels in the plasma of children with iron deficiency anemia prompted us to hypothesize that ghrelin may affect iron metabolism. Here, we investigated the effects of fasting or ghrelin on the expression of hepcidin, ferroportin 1 (Fpn1), transferrin receptor 1 (TfR1), ferritin light chain (Ft-L) proteins, and ghrelin, and also hormone secretagogue receptor 1 alpha (GHSR1α) and ghrelin O-acyltransferase (GOAT) mRNAs in the spleen and/or macrophage. We demonstrated that fasting induces a significant increase in the expression of ghrelin, GHSR1α, GOAT, and hepcidin mRNAs, as well as Ft-L and Fpn1 but not TfR1 proteins in the spleens of mice in vivo. Similar to the effects of fasting on the spleen, ghrelin induced a significant increase in the expression of Ft-L and Fpn1 but not TfR1 proteins in macrophages in vitro. In addition, ghrelin was found to induce a significant enhancement in phosphorylation of ERK as well as translocation of pERK from the cytosol to nuclei. Furthermore, the increased pERK and Fpn1 induced by ghrelin was demonstrated to be preventable by pre-treatment with either GHSR1α antagonist or pERK inhibitor. Our findings support the hypothesis that fasting upregulates Fpn1 expression, probably via a ghrelin/GHSR/MAPK signaling pathway.

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Plasma Ghrelin Levels in Various Stages of Development of Iron Deficiency Anemia

Abstract: A significant positive correlation was demonstrated between iron status of the body and levels of ghrelin. Decrease in ghrelin levels in IDA can lead to loss of appetite, desire to eat diverse foods with resultant delay in growth and development.

Cited by 33 publications

References 20 publications

Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

Effect of in ovo ghrelin administration on serum malondialdehyde level in newly-hatched chickens

Fasting up‐regulates ferroportin 1 expression via a Ghrelin/GHSR/MAPK signaling pathway

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