Plasma Glutathione Peroxidase and Its Relationship to Renal Proximal Tubule Function

Renal function of chloralkali workers after the cessation of exposure to mercury vapor

“…It has also been suggested that patients should be monitored with respect to S-GSHpx before the administration of nephrotoxic drugs so that those with a particular risk associated with certain medications can be identified (26). Our results could have the implication that exposure to other metals (eg, mercury) that are toxic to the proximal tubule cells may have their effects modified by the differences in the selenium status.…”

“…These cells are also the major source of extracellular GSHpx (25,26). However, there were only small differences between S-GSHpx and S-Se in the impact on the U-NAG activities.…”

“…A previous epidemiologic study of chloralkali workers suggested that selenium status may modify the effect of exposure to mercury vapor on U-NAG activity (10). The human kidney is rich in selenium, and selenium-dependent glutathione peroxidase (GSHpx) in plasma is, to a large extent, synthesized in the proximal tubule cells (24)(25)(26).…”

Selenium (Se), Blood Glutathione Peroxidases and DNA Damage in Chronic Kidney Disease Patients on Hemodialysis and After Kidney Transplantation - The Effect of Se Supplementation

“…Data on Se concentration and GSH-Px activities, and some other parameters, in blood of patients after kidney transplantation is still rather scarce. To the best of my knowledge there were, except ours, two research centers reporting the results on the antioxidant status in patients in early stages after kidney transplantation: one in the United States (Avissar et al, 1994;Whitin et al, 1998) and one in Spain (De Vega et al, 2002;2003). In this article I will focus on the GSH-Px.…”

“…Therefore it is worthwhile to concentrate primarily on plasma GSH-Px in CKD patients. Studies on this enzyme have shown that although GSH-Px 3 is synthesized in a range of tissues, the renal proximal tubular epithelial cells are the main source from which it is secreted into plasma (Avissar et al, 1994;Whitin et al, 1998). Many reports indicate that patients with CKD have very low plasma GSH-Px activity (Yoshimura et al, 1996, Zachara et al, 2004a, Ceballos-Picot et al, 1996 including those undergoing HD (Yoshimura et al, 1996, Roxborough et al, 1999, Ceballos-Picot et al, 1996, Zachara et al, 2001a.…”