Plasma Homocysteine and Insulin in Diabetic Nephropathy: Relationship to Body Mass Index

Abstract

The data on plasma homocysteine and endogenous insulin in type 2 diabetes mellitus with nephropathy and relationship to body mass index (BMI) is particularly from the Indian subcontinent. A prospective study was carried out in 50 patients of type 2 diabetes mellitus with overt nephropathy (Group A). The results were compared with 25 diabetics without nephropathy (Group B), and 25 age and sex matched healthy controls (Group C). Microenzyme immunoassay and ELISA estimated the plasma homocysteine and insulin, respectively. The mean values of plasma homocysteine were significantly elevated in diabetic nephropathy (21.3+/-7.2 micromol/L) and diabetics without nephropathy (19.4+/-7.1) when compared to healthy control (11.5+/-2.3). The insulin levels and BMI were significantly higher in diabetics as compared to controls. There was no correlation between homocysteine and insulin, homocysteine and BMI, and homocysteine with the degree of renal failure.

Associations between serum insulin and homocysteine in a Swedish population—a potential link between the metabolic syndrome and hyperhomocysteinemia: The Skaraborg project

“…These circumstances may have reduced the power to detect any differences associated with smoking, and the possibility of a type 2 error should be considered. Like in many previous studies, BMI and other markers for obesity were not significant determinants of Hcy [21,[43][44][45]. We cannot, however, conclusively rule out an association because levels of Hcy were highest in obese subjects in both men and women, and the possibility of insufficient power should be considered.…”

Genetically elevated circulating homocysteine concentrations increase the risk of diabetic kidney disease in Chinese diabetic patients

“…Homocysteine is a sulphur‐containing non‐proteinogenic amino acid biosynthesized from methionine and abnormal elevation of circulating homocysteine concentrations has been implicated in the development of many clinical end‐points or pathological conditions, such as cardiovascular disease, stroke and microalbuminuria . Hyperhomocysteinaemia is an independent risk factor for glomeruloslerosis and renal insufficiency and the association of circulating homocysteine with DKD was widely evaluated in the medical literature, yet the results are not often reproducible . Actually, current evidence linking homocysteine to DKD is mainly based on observational data, in which the degree of possible confounding and reverse causation may cloud the true relationship .…”

“…17 Hyperhomocysteinaemia is an independent risk factor for glomeruloslerosis and renal insufficiency and the association of circulating homocysteine with DKD was widely evaluated in the medical literature, yet the results are not often reproducible. [7][8][9][18][19][20][21][22] Actually, current evidence linking homocysteine to DKD is mainly based on observational data, in which the degree of possible confounding and reverse causation may cloud the true relationship. 23,24 In this context, Mendelian randomization has proven to be a valuable method to overcome confounding and reverse causality 25,26 and this method enables estimation of causal relationship in observational studies using genetic alterations as instruments.…”

Associação Da Homocisteína E LDL Em Mulheres Idosas Com Diabetes Do Tipo 2

“…A homocisteína pode aumentar a rigidez arterial e facilita absorção da LDL (YUN et al, 2011;THAMPI et al, 2008;KOUBAA et al, 2007). Segundo Coppola et al (2000) LIN et al, 2008;DE LUIS et al, 2005;SANDHU et al, 2004 et al, 2005).…”