Plasma immunoglobulin levels in patients with breast cancer

Abstract

The plasma levels of the immunoglobulins IgA, IgG and IgM have been measured in 55 patients with benign breast disease, 28, 68 and 22 patients with early breast cancer one day before, 10-14 days after and three-six months after mastectomy, respectively, and 35 normal healthy control women. The mean levels of IgA, IgG and IgM were similar for all groups examined except for IgG levels in breast cancer patients 10-14 days after mastectomy. In this latter case there was a significant decrease in IgG level shortly after mastectomy but at three-six months after surgery the amounts of plasma IgG were within the normal range. There was no correlation between the amounts of immunoglobulin measured at 10-14 days after surgery, and time to recurrence of the disease.

Correlation of Immunoglobulin G Expression and Histological Subtype and Stage in Breast Cancer

“…The infiltrating B lymphocytes and plasma cells also contain IgG. Previous studies have been conducted to correlate plasma IgG levels to breast cancer development [25], [26], [27], [28]. The increased plasma IgG level could be derived from the patients' immune response or from cancer-produced IgG.…”

Effets d'une supplémentation en antioxydants sur les taux circulants des immunoglobulines IgA, IgG et IgM chez des femmes récemment mastectomisées, en traitement chimiothérapeutique

“…Chez des patientes atteintes d'un cancer du sein, les taux d'IgA étaient maintenus constants alors que les IgG étaient significativement réduites [7]. De même, Wang et al [8] observent une diminution des taux d'IgG 10 à 14 jours après mastectomie, et un retour à la normale de ces taux trois ou six mois après l'opération. Selon Alsabti [9], il existe une corrélation positive entre la progression des métastases du cancer du sein et les taux d'IgA et une corrélation négative entre la progression tumorale et les taux d'IgM.…”