Plasma interleukin-6 levels are increased in coronary artery ectasia

Tokgözoğlu, Lâle; Ergene, Oktay; Kınay, Ozan; Nazlı, Cem; Hasçelik, Gülşen; Hoşcan, Yeşim

doi:10.2143/ac.59.5.2005226

Cited by 59 publications

(49 citation statements)

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“…A limited number of studies have evaluated the role of inflammatory (CRP and IL-6) and proteolytic markers (MMPs, TIMPs) in the CAE patients. [8][9][10][11][12][13] They provided divergent results.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase-9 (MMP9) and high sensitivity C – Reactive protein (hs-CRP) in coronary artery ectasia

Ammar

Kappary

Baghdady

et al. 2013

The Egyptian Heart Journal

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Objective: The specific causative mechanisms of abnormal luminar dilatation in coronary artery ectasia (CAE) are essentially unknown. Destruction of the extracellular matrix may be responsible for ectasia formation. Thus, we investigated the role of matrix metalloproteinases (MMP9), and inflammatory marker (high-sensitive C-reactive protein) in CAE patients. Methods: This study consisted of 30 consecutive CAE patients, 30 obstructive coronary artery disease (CAD) patients, and 20 controls with normal coronary arteries undergoing cardiac catheterization. Plasma levels of MMP-9, and hs-CRP were measured. Results: Hs-CRP level was significantly higher in the the CAE group than both in the CAD and control groups (2.3 ± 0.5, 1.19 ± 0.54, 0.8 ± 0.3 mg/l, respectively, both p < 0.001), while, MMP-9 level was significantly higher in both CAE group and CAD than control groups (27.71 ± 4.7, 25.2 ± 4.1, 18.6 ± 3.3 ng/ml, respectively , both p < 0.001). In subgroup analyses, MMP-9 level was significantly higher in CAE patients with multivessel involvement compared to those with single-vessel ectasia (29.4 ± 3.1 vs. 25.2 ± 5.5 ng/ml, P = 0.01), while hs CRP level was comparable in both groups (2.3 ± 0.52 vs. 2.4 ± 0.45 ng/ml, P = 0.82). Conclusion: Our results suggest that the increased levels of MMP-9, hs-CRP may be responsible for ectasia formation in patients with CAE and plasma level of MMP-9 is correlated with the severity of CAE.

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Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase-9 (MMP9) and high sensitivity C – Reactive protein (hs-CRP) in coronary artery ectasia

Ammar

Kappary

Baghdady

et al. 2013

The Egyptian Heart Journal

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“…Tokgozoglu et al [17] reported elevated plasma levels of inflammatory markers such as interleukin-6 and C-reactive protein (CRP) in CEA patients comparing with those with normal coronary. In another study from Ozbay [18], significantly elevated hs-CRP levels in CEA patients than that in AS patients, and significant decreased hs-CRP levels after a 3-month statins therapy, also showing CEA patients may benefit from statins.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and coronary features of coronary ectasia and aneurysm in China

Cheng¹,

Liu²,

Zhang³

et al. 2013

WJCD

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Objective: To describe the clinical characteristics and coronary features of patients with coronary ectasia and aneurysm (CEA) in China. Methods: This was a single center, retrospective clinical study. Patients with CEA who diagnosed by coronary artery angiography (CAG) from April 2003 to October 2009, were enrolled. All patients were followed up by the call or clinic visit. The primary outcome was all-cause mortality or cardiovascular readmission. Results: A total of 39 patients (27 males, mean age 59.5 ± 12.6 years) diagnosed with CEA, with a prevalence of 0.6% (a total of 6130 patients underwent CAG during the same period). Thirty-six patients constituted the study population, due to 3 patients lost of followup. The median follow-up was 27 months (1 -76). The single vessel was involved in 11 patients (31%), two vessels were involved in 14 patients (38%) and three or more vessels were involved in 11 patients (31%). The most common involved vessel was left anterior descending branch (n = 27), followed by right coronary artery (n = 23), left circumflex branch (n = 20) and left main branch (n = 9). There was no death during the follow-up. The primary outcome was observed in 8 (22%) patients. The use of clopidogrel and statins were associated with lower rate of cardiovascular readmission. Conclusion The incidence of CEA was low among patients who referred for CAG in China. The majority of patients had the involvement of multiple vessels, and left anterior descending branch was the most common involved vessel. The CEA patients may benefit from clopidogrel and statins.

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“…Whether the same mechanisms are operative in CAE is not known. However, elevation of inflammatory markers such as interleukin-6 has been shown in both AAA and CAE [18,19]. Intrinsic defects of the media or systemic factors may predispose the media to form aneurysms.…”

Section: Discussionmentioning

confidence: 99%

Severe coronary artery ectasia and abdominal aortic aneurysm

2006

Schweiz Ärzteztg

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SummaryCoronary artery ectasia (CAE), a discrete or fusiform arterial dilatation, is an uncommon angiographic finding. We report the case of a patient presenting with an acute coronary syndrome in whom further evaluation revealed coronary artery disease with severe CAE in the presence of an abdominal aortic aneurysm (AAA). Since both entities are strongly associated with local and systemic atherosclerosis, they have traditionally been viewed as a variant of atherosclerosis. The combined occurrence of CAE and AAA, as in the present case, raises questions about common pathogenetic mechanisms apart from atherosclerosis. The respective evidence will be reviewed.

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Plasma interleukin-6 levels are increased in coronary artery ectasia

Cited by 59 publications

References 0 publications

Matrix metalloproteinase-9 (MMP9) and high sensitivity C – Reactive protein (hs-CRP) in coronary artery ectasia

Matrix metalloproteinase-9 (MMP9) and high sensitivity C – Reactive protein (hs-CRP) in coronary artery ectasia

Clinical characteristics and coronary features of coronary ectasia and aneurysm in China

Severe coronary artery ectasia and abdominal aortic aneurysm

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