Plasma interleukin-6 levels in Mediterranean spotted fever

Oristrell, J; Sampere, Moga; Amengual, M. J.; Font, Bernat; Segura, Ferrán

doi:10.1007/s10096-004-1121-9

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…13,16 Other authors studied IL-6 in dynamics and our data did not differ much from theirs. 7,17 The original prominence of IL-6 value in the convalescence (that we observed after the cytokine sharply dropped at the time of clinical recovery, Fig. 1c), could be related to the fact that IL-6 acts as a growth factor for B cell differentiation and immunoglobulin production.…”

Section: Discussionmentioning

confidence: 79%

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Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever

Popivanova¹,

Murdjeva²,

Baltadzhiev³

et al. 2011

Folia Medica

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Mediterranean spotted fever (MSF) is a re-emerging rickettsiosis in Bulgaria after 20 years of absence (1972-1992), and it has since been affecting many people annually in the endemic regions of the country. The role of cytokines in MSF is still in the focus of research due to their complex participation in the immune pathogenesis of the disease. Aim: To study the changes in the serum cytokine concentrations in MSF patients. Patiends and Methods: Eighty patients with MSF and 20 healthy controls were enrolled in the study. The pro-inflammatory and immunoregulatory cytokines IL-1β, TNF-α, IL-6, IL-8, IL-12, IFN-γ, IL-2, and IL-10 were studied in the burst of disease, at clinical recovery stage, and two weeks later. The disease etiology was verified by indirect IFA in the Referral Rickettsiosis Laboratory. The cytokine levels were determined by EL ISA (BioSource Europe S.A). Results: In the disease flare up patients showed a manifold increase in the activity of IL- 1β (р < 0.01), TNF-α (p < 0.001), IL-6 (р < 0.001), and IL-8 (p < 0.001) compared with the controls. Significant elevation in IFN-γ and IL-12 values (p < 0.001) was also found. The increase in the immunoregulatory IL-10 also reached statistical significance (p < 0.001), while the rise in IL-2 did not (р > 0.05). Followed in dynamics, only IL-1β and IL-6 measured up the control levels at the time of clinical recovery. Two weeks later, in the early convalescence IL-12 and TNF-α further diminished but did not normalize their values. Conclusion: Our findings show that MSF is characterized by a Th1 cytokine profile. The patient’s immune system responds by proinflammatory and immunoregulatory cytokine production that accompanies the rickettsial vasculitis and contributes to the healing process. The latter is probably not fully achieved in the early convalescent period, according to our data concerning some pro-inflammatory cytokines’ elevation at this period.

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Section: Discussionmentioning

confidence: 79%

“…Studies of a single or group of cytokines in MSF patients have been performed by a few researchers. [4][5][6][7] The pioneer study of cytokines in MSF patients in Bulgaria was implemented by our team. 8,9 The present article aims to investigate the changes in pro-inflammatory and immunoregulatory cytokine expression in MSF patients' blood sera.…”

mentioning

confidence: 99%

Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever

Popivanova¹,

Murdjeva²,

Baltadzhiev³

et al. 2011

Folia Medica

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“…Since Rickettsia infection of EC also induces IL-6 secretion (Vitale et al, 2001;Jensenius et al, 2003;Oristrell et al, 2004), the presence of cytokines and chemokines with specialized functions might be necessary to achieve appropriate inflammatory responses during in vivo infection. This study reveals a similar pattern of increased expression and secretion of regulatory chemokines IL-8 and MCP-1 during R. rickettsii infection of EC, both of which participate in the recruitment of PMN and monocytes to the site of infection and the onset as well as progression of vascular inflammation.…”

Section: Article In Pressmentioning

confidence: 99%

Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after infection: Regulation by nuclear transcription factor NF-B

Clifton

Rydkina

Huyck

et al. 2005

International Journal of Medical Microbiology

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“…The increased vascular permeability during rickettsial infection may also be mediated by the production of cytokines and chemokines. In vivo and in vitro studies have shown that rickettsial infection of endothelial cells stimulates the release of proinflammatory cytokines, such as IL-1 , IL-6 and IL-8 Oristrell et al, 2004;Damas et al, 2009], as well as the secretion of chemokines, such as CCL-2, CCL-5, CXCL-9, CXCL-10 and CX3CL-1 [Bechah et al, 2008;Bechah et al, 2007;Valbuena et al, 2003;Valbuena and Walker D. H., 2005]. Additional in vitro and in vivo studies have also shown that infection increases the expression of adhesive molecules, such as E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) [Dignat-George et al, 1997;Damas et al, 2009]; these adhesive molecules regulate leukocyte movement between the circulation and the surrounding tissues.…”

Section: Endothelium and Pathophysiology Of Rickettsiosesmentioning

confidence: 99%