2014
DOI: 10.1053/j.tcam.2014.09.005
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Plasma Lactate Concentration as a Prognostic Biomarker in Dogs With Gastric Dilation and Volvulus

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Cited by 31 publications
(37 citation statements)
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“…Another systematic review evaluating acutely ill patients admitted to the hospital concluded that all patients with a lactate concentration of > 2.5 mmol/L should be closely monitored for signs of deterioration, and several of the included studies demonstrated a positive correlation between lactate and mortality . Lactate concentration has also been shown to have prognostic significance in a variety of veterinary disease populations . Given the results of previous studies, in addition to the current investigation, routine plasma lactate concentration monitoring may be valuable in evaluation of the emergency room patient.…”
Section: Discussionmentioning
confidence: 83%
See 1 more Smart Citation
“…Another systematic review evaluating acutely ill patients admitted to the hospital concluded that all patients with a lactate concentration of > 2.5 mmol/L should be closely monitored for signs of deterioration, and several of the included studies demonstrated a positive correlation between lactate and mortality . Lactate concentration has also been shown to have prognostic significance in a variety of veterinary disease populations . Given the results of previous studies, in addition to the current investigation, routine plasma lactate concentration monitoring may be valuable in evaluation of the emergency room patient.…”
Section: Discussionmentioning
confidence: 83%
“…Hyperlactatemia has been associated with increased mortality in people in many clinical scenarios including trauma, infection, sepsis, and cardiac arrest . Hyperlactatemia has been associated with poor outcome in dogs with sepsis, gastric dilatation‐volvulus, systemic hypotension, and immune‐mediated hemolytic anemia . In 2 recent studies, hyperlactatemia was associated with the need for blood transfusions in both dogs that sustained trauma and dogs that underwent splenectomy for splenic masses .…”
Section: Introductionmentioning
confidence: 99%
“…Samples are generally run on whole blood anticoagulated with heparin or EDTA, without the use of glycolytic agents, which could halt red blood cell energy metabolism and limit spurious increases in lactate concentrations. Because lactate is becoming more relied upon as a prognostic marker 12,13 and guide for resuscitation strategies, it is crucial that alterations in lactate levels secondary to room temperature storage are well understood. Based on this study, blood samples analyzed after a delay of greater than 7.5 minutes at room temperature should be interpreted with caution.…”
Section: Discussionmentioning
confidence: 99%
“…This discrepancy indicates the need for further studies with larger sample populations in order to understand the real importance of acute-phase proteins as an outcome-specific predictor. Plasma lactate concentration and plasma lactate clearance during resuscitation are the most studied and commonly used parameters in clinical practice [ 6 , 10 , 19 , 20 ], although their usefulness is not completely understood. Israeli et al argued that lactate concentration is mostly affected by the severity of systemic hypoperfusion, acidosis and shock, and that it is only indirectly associated with the presence and extent of gastric wall necrosis [ 17 ].…”
Section: Discussionmentioning
confidence: 99%