Prognostic value of canine pancreatic lipase immunoreactivity and lipase activity in dogs with gastric dilatation-volvulus

Spinella, Giuseppe; Dondi, Francesco; Grassato, Lisa; Magna, Luca; Cola, Veronica; Giunti, Massimo; Magno, Sara Del; Valentini, Simona

doi:10.1371/journal.pone.0204216

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Pancreatic lipase concentrations are increased in several infectious diseases including parvovirus gastroenteritis, babesiosis, and monocytic ehrlichiosis 103‐106 . Pancreatic lipase concentrations also may be increased in dogs with intervertebral disc disease, foreign bodies and gastric‐dilatation and volvulus 49,107‐109 . These increases in pancreatic lipase concentration may be secondary effects on the exocrine pancreas associated with the primary disease condition.…”

Section: Pancreatic Lipase Concentrations In Dogs With Primary Diseases Other Than Pancreatitismentioning

confidence: 99%

Advances in the diagnosis of acute pancreatitis in dogs

Cridge

Twedt

Marolf

et al. 2021

Veterinary Internal Medicne

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In the last 20 years, the diagnosis of pancreatitis has become more frequent as a result of improved diagnostic modalities such as abdominal ultrasound examination, advanced imaging, and immunoassays for the measurement of pancreatic lipase. Our aim is to provide a state‐of‐the‐art overview of the clinical diagnosis of acute pancreatitis (AP) in dogs with a particular focus on pancreatic lipase assay validation and clinical performance, in addition to advanced imaging modalities. We also discuss the potential indications for cytology and histopathology in dogs with suspected AP.

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Section: Pancreatic Lipase Concentrations In Dogs With Primary Diseases Other Than Pancreatitismentioning

confidence: 99%

Advances in the diagnosis of acute pancreatitis in dogs

Cridge

Twedt

Marolf

et al. 2021

Veterinary Internal Medicne

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“…Serum concentrations increase in dogs with systemic inflammation following surgery, trauma, infections, or neoplasia ( 21 ). Concentrations of CRP were commonly increased in dogs with GDV ( 7 , 22 , 23 ) and were significantly associated with a negative outcome in one study ( 24 ).…”

Section: Introductionmentioning

confidence: 95%

Kinetics of Plasma Cytokines, Angiopoietin-2, and C-Reactive Protein in Dogs With Gastric Dilatation Volvulus

et al. 2021

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Background: The degree of systemic inflammation, reperfusion injury and endothelial activation are potentially important determinants of clinical outcomes in dogs with gastric dilatation volvulus (GDV).Objective: To evaluate plasma concentrations and kinetics of inflammatory markers in dogs with GDV over a time frame of 48 h, and to compare to healthy dogs.Design and Setting: Prospective, observational cohort study in client-owned dogs with GDV.Materials and Methods: Fifteen dogs with GDV and 9 healthy control dogs were enrolled. Plasma concentrations of interleukin (IL)-6, IL-7, IL-8, IL-10, IL-15, IL-18, interferon gamma (IFN-γ), keratinocyte chemotactic-like, monocyte chemotactic protein (MCP)-1, Angiopoietin (Ang)-2, and C-reactive protein (CRP) were measured at admission (prior any therapeutic intervention, (T0), immediately after surgery (T1), 24 ± 4 h (T24), and 48 ± 4 h (T48) post-surgery. Cytokines were measured using multiplex magnetic bead assay. Plasma Ang-2 was measured with a commercial human ELISA test kit validated for dogs.Results: Dogs with GDV had significantly higher plasma concentrations of IFN-γ and IL-10 compared to healthy control dogs at all time points. Concentrations of IL-6 were significantly higher at T1 and T24, concentrations of MCP-1 at T24, and concentrations of CRP at T24 and T48. A significant increase between T0 and T1 was found for IL-6, IL-10, and CRP, between T1 and T24 for IL-8, IFN-γ, MCP-1, and CRP, and between T24 and T48 for IL-15, Ang-2, and CRP. A significant decrease between T0 and T1 was found for IL-7, IL-8, IL-15, IL-18, and Ang-2; between T1 and T24 for IL-6 and KC-like; and between T24 and T48 for IL-6.Conclusion: In GDV dogs, a mild pro-inflammatory reaction was present at admission, which peaked immediately after and up to 24 h post-surgery, mainly represented by IL-6, IFN-γ, MCP-1, and CRP, and which decreased at T48. In addition, the anti-inflammatory IL-10 was increased in GDV dogs at all time points.

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“…The 15-day mortality rate in this study was 20.7%. There is no comparable veterinary study with which to compare data, however, mortality rates reported in veterinary medicine for the most common surgical procedures encountered here, like gastrointestinal, hemoperitoneum or GDV syndrome surgeries, range from 0.8 to 28% [21][22][23][24][25][26], 12 to 36% [27,28] and 12 to 26 % [29][30][31][32][33][34][35][36], respectively.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Outcome in Dogs Undergoing Emergency Abdominal Surgery: A Retrospective Study on 82 Cases (2018-2020)

Fages¹,

Soler²,

Fernandez‐Salesa³

et al. 2021

Preprint

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Emergency abdominal surgery carries high morbidity and mortality rates in human medicine; however, there is less evidence characterizing the outcome of these surgeries as a single group in dogs. The aim of the study was to characterize the clinical course, associated complications and outcome of dogs undergoing emergency abdominal surgery. A retrospective study was conducted. Dogs undergoing emergency laparotomy were included in the study. Logistic regression analysis was performed to identify variables correlated with death and complications. Eighty-two dogs were included in the study. The most common reason for surgery was gastrointestinal foreign body. Overall 15-day mortality rate was 20.7% (17/82). Median (range) length of hospitalization was 3 (0.5 - 15) days. Of the 82 patients, 24 (29.3%) developed major complications and 66 (80.5%) minor complications. Perioperative factors significantly associated with death included tachycardia (P &lt; 0.001), hypothermia (P &lt; 0.001), lactate acidosis (P &lt; 0.001), shock index &gt; 1 (P &lt; 0.001), leukopenia (P &lt; 0.001), thrombocytopenia (P &lt; 0.001) at admission; intraoperative hypotension (P &lt; 0.001) and perioperative use of blood products (P &lt; 0.001). The results of this study suggest that mortality and morbidity rates after emergency abdominal surgery in dogs are high.

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Prognostic value of canine pancreatic lipase immunoreactivity and lipase activity in dogs with gastric dilatation-volvulus

Cited by 13 publications

References 28 publications

Advances in the diagnosis of acute pancreatitis in dogs

Advances in the diagnosis of acute pancreatitis in dogs

Kinetics of Plasma Cytokines, Angiopoietin-2, and C-Reactive Protein in Dogs With Gastric Dilatation Volvulus

Perioperative Outcome in Dogs Undergoing Emergency Abdominal Surgery: A Retrospective Study on 82 Cases (2018-2020)

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