Plasma lecithin: cholesterol acyltransferase activity in elite athletes from selected sports

Tsopanakis, Christi; Kotsarellis, D.; Tsopanakis, A

doi:10.1007/bf00417260

Cited by 26 publications

(9 citation statements)

References 18 publications

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“…28 This process is mediated by cholesterol ester transfer protein; however, the role of this enzyme is difficult to discern, as both an increase 27 and decrease 29 have been reported with exercise training. A similar situation is evident with lecithin cholesterol acyltransferase, as either an increase 30 or no change 31 has been observed with training intervention; however, a decrease in hepatic lipase activity is evident with physical activity.…”

Section: Discussionsupporting

confidence: 55%

Effects of exercise training on the chemical composition of plasma LDL.

Houmard

Bruno

Bruner

et al. 1994

Arterioscler Thromb

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The purpose of the present study was to determine the effects of exercise training on the chemical composition of plasma low-density lipoprotein (LDL). Thirteen men (mean age±SE, 47.2±1.5 years) were examined before and after 14 weeks of endurance-oriented exercise training (3 to 4 d/wk, 30 to 45 min/d). Although calculated plasma LDL concentrations remained unaltered (3.49±0.24 versus 3.65±0.23 mmol/L), changes in the chemical composition of LDL (increased LDL free cholesterol, cholesterol ester, and phospnolipid content) were associated with a reduction in adiposity, umbilical girth, and basal plasma insulin and glucose concentration with training intervention. Increases in LDL

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Section: Discussionsupporting

confidence: 55%

Effects of exercise training on the chemical composition of plasma LDL.

Houmard

Bruno

Bruner

et al. 1994

Arterioscler Thromb

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“…Small intestine and liver ATP contents were determined by Bioaffina GmbH (Germany) ATP sensitive Bioluminescence kit. Plasma preb HDL was separated according Ishida et al (Tsopanakis et al 1988) agarose electrophoresis method, and then assaying ApoA1 in preb HDL band was done using Rat ApoA1 Enzyme immunoassay kit (Wuhan USCN Sciences Co Ltd, Wuhan, China).…”

Section: Lipids and Lipoproteinsmentioning

confidence: 99%

“…It was shown that acute exercise, exercise training, and fitness can favorably affect the several key steps in RCT such as Enhanced cellular cholesterol efflux (Brites et al 2004), increased formation and size of Apo A-I (Wilund et al 2002;Olchawa Beata 2004), increased plasma pre-b HDL levels (Jafari et al 2003;Sviridov et al 2003), increased LCAT activity (Cumhur Kilinç et al 2000;Olchawa Beata 2004;Tsopanakis et al 1988), and increased HDL-C level (Durstine et al 2001). But studies to examine the effect of exercise training on ABCA1 are really rare.…”

Section: Introductionmentioning

confidence: 97%

Endurance training enhances ABCA1 expression in rat small intestine

et al. 2009

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The purpose of this study was to investigate liver and intestinal ABCA1 expression and plasma HDL-C level in response to treadmill-running training in rats. Twenty adult Wistar male rats (17-18 weeks old, 300-322 g) were divided into control (n = 10) and Training (n = 10) groups. Training group trained at 25 m/min (0% grade) for 60 min/day, 5 days/week for 12 weeks. Rats were killed 48 h after the last session of training. The intestinal and liver ABCA1 mRNA expression was found to be significantly higher in trained compared to control group (P < 0.006 and P < 0.024, respectively). Intestine and liver ATP concentrations remained unchanged. Plasma HDL-C, HDL2-C, Apo A-1, pre-beta HDL-C concentration, LCAT activity, TC/HDL-C and LDL-C/HDL-C ratio significantly increased in trained group (P < 0.01, P < 0.006, P < 0.001, P < 0.001 P < 0.067, P < 0.02, and P < 0.03, respectively). However, other lipoprotein concentrations were unchanged. In conclusion, we found that endurance training induced significant elevation in plasma HDL-C and HDL2-C concentrations, accompanied by higher plasma Apo A-1, pre-beta HDL-C concentrations, LCAT activity and ABCA1 mRNA expressions in rat intestine, and liver.

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“…In addition, heparin administration and corporal training increase the LCAT activity (Tsopanakis et al 1988;Tsopanakis and Tesserommatis 1991).…”

Section: Discussionmentioning

confidence: 99%

Impact of hyperlipidaemia on the orbital bone cefotaxime levels in rats

Panitsa¹,

Panitsas²,

Potamianou³

et al. 2010

Eur J Drug Metab Pharmacokinet

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Facial injuries are critical conditions, leading to serious complications, such as occult facial infections. Infectious endophthalmitis occurs despite of antibiotics use during implantation of intraocular lenses and is generally resistant to antibiotic therapy. It is a crucial situation in ophthalmology, since it often induces a substantial reduction of visual acuity and in some cases the loss of the eye despite treatment. It is, therefore, important to obtain drug levels able to exert antimicrobial effect in the diseased organ. The distribution of a drug depends on the binding extent to both plasma proteins and tissues and only the free drug is capable to be transported/diffused across membranes from blood vessels into tissues, in order to achieve its effect on the target organ. Hyperlipidaemia and consequent enhanced concentration of free fatty acid can modify binding pharmacokinetics of antibiotics through antagonism for the same binding sites. Cefotaxime, the third generation cephalosporin with easy penetration in a variety of tissues and body fluids and low incidence of adverse effects, can obtain adequate concentration in blood, eye bulb, and in the orbital bones. Its levels are influenced by hyperlipidaemia with clinical impact.

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Plasma lecithin: cholesterol acyltransferase activity in elite athletes from selected sports

Cited by 26 publications

References 18 publications

Effects of exercise training on the chemical composition of plasma LDL.

Effects of exercise training on the chemical composition of plasma LDL.

Endurance training enhances ABCA1 expression in rat small intestine

Impact of hyperlipidaemia on the orbital bone cefotaxime levels in rats

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