Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study

Abstract

Many studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2) is associated with metabolic disorders, which is a risk factor of arteriosclerosis. We assessed the level of LECT-2 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participants who underwent coronary angiography in our hospital and included patients with non-CAD, patients with stable angina pectoris (SAP), patients with unstable angina (UA), patients with non-ST-segment elevation myocardial infarction (NSTEMI) and patients with ST-segment elevation myocardial infarction (STEMI). The serum level of LECT-2 was higher in patients with CAD than in patients with non-CAD and was an independent predictor for CAD. Subgroup analysis showed that compared with the SAP group, the UA, NSTEMI, and STEMI groups had higher serum levels of LECT-2. In addition, the level of LECT-2 was related to the SYNTAX score and SYNTAX II score. Finally, patients with acute myocardial infarction (AMI) with elevated levels of LECT-2 had a higher risk of major adverse cardiovascular events (MACEs) within 12 months than those with lower levels of LECT-2. Plasma LECT-2 levels may be useful for the diagnosis of CAD and as predictors of MACE in patients with AMI.

Plasma Leukocyte Cell-Derived Chemotaxin 2 for the Severity of Coronary Artery Disease

“…Thus, it seems that the MHR is significantly higher in the CAD group. However, Wei et al 1 did not calculate the MHR for their study population.…”

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Dear Editor,We read the recent article entitled "Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study" by Wei et al 1 with great interest. They demonstrated that the serum level of LECT2 was higher in patients with coronary artery disease (CAD) than in patients with non-CAD and was an independent predictor for CAD.

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“…The level of LECT-2 was also related to the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score and SYNTAX II score. 1 Furthermore, patients with acute myocardial infarction (AMI) with elevated levels of LECT-2 had a higher risk of major adverse cardiovascular events (MACEs) within 12 months than those with lower levels of LECT-2. 1 They concluded that plasma LECT-2 levels may be useful for the diagnosis of CAD and as predictors of MACE in patients with AMI.…”

“…1 They concluded that plasma LECT-2 levels may be useful for the diagnosis of CAD and as predictors of MACE in patients with AMI. 1…”

“…Our recent studies also pointed out that serum total bilirubin, resting heart rate, and the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years (doubled), diabetes mellitus, previous stroke or transient ischemic attack (doubled), vascular disease, age 65 to 74 years, and female gender) score were independent risk factors and novel prognostic markers for cardiovascular events, in-hospital mortality, as well as the extent, severity, and complexity of CAD. 5-9 The authors 1 did not report these parameters in their study, and they did not analyze these possible confounding factors in the univariate and multivariate logistic regression model.…”