Plasma Level of Interferon-γ Predicts the Prognosis in Patients With New-Onset Atrial Fibrillation

Huang, Jiaqi; Xiang, Ying; Zhang, Huan; Wu, Na; Chen, Xinghua; Wu, Long; Xu, Bin; Li, Chengying; Zhang, Zhihui; Tong, Shifei; Zhong, Li; Li, Yafei

doi:10.1016/j.hlc.2019.11.004

Cited by 10 publications

(10 citation statements)

References 37 publications

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“…Indeed, numerous studies have linked high levels of interferon gamma with AF. Such AF associations with increased interferon gamma, have been observed in, community patients presenting with new onset AF, 77 in recovery in postcardiac bypass patients, 78 and more rarely in lupus patients receiving high‐dose corticosteroids 79 . Currently it appears that CD4+ T cell interferon gamma responses cannot be manipulated clinically.…”

Section: Introductionmentioning

confidence: 99%

Atrial fibrillation in COVID‐19: A review of possible mechanisms

2020

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A relationship between COVID‐19 infection and an increasing incidence of atrial fibrillation has been observed. However, the underlying pathophysiology as a precipitant to AF has not been reviewed. This paper will consider the possible pathological and immunological AF mechanisms as a result, of COVID‐19 infection. We discuss the role myocardial microvascular pericytes expressing the ACE‐2 receptor and their potential for an organ‐specific cardiac involvement with COVID‐19. Dysfunctional microvascular support by pericytes or endothelial cells may increase the propensity for AF via increased myocardial inflammation, fibrosis, increased tissue edema, and interstitial hydrostatic pressure. All of these factors can lead to electrical perturbances at the tissue and cellular level. We also consider the contribution of Angiotensin, pulmonary hypertension, and regulatory T cells as additional contributors to AF during COVID‐19 infection. Finally, reference is given to two common drugs, corticosteroids and metformin, in COVID‐19 and how they might influence AF incidence.

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Section: Introductionmentioning

confidence: 99%

Atrial fibrillation in COVID‐19: A review of possible mechanisms

2020

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“…Elevated serum levels of IL-1β, IL-6 and hs-CRP (high-sensitive C-reactive-Protein) were demonstrated to be associated with increased duration and incidence of AF in patients with cardiac inflammation [20] . Consistent with these observations, Kawaji and collaborators reported that IL-17A and IL-1β were among the top up-regulated cytokines in AF patients with severe LVZ [14] . Interestingly, Kawaji and co-authors reported that IL-6 and IFN-γ were negatively associated with severe LVZ, which seems inconsistent with the previously described proinflammatory, profibrotic and proarrhythmogenic effects of these cytokines [10] , [13] , [15] .…”

Section: Inflammatory Biomarkers As Indicators Of Atrial Low Voltage Zonementioning

confidence: 53%

“…In this context, IL6 levels have been shown to be elevated in patients with increased left atrial size and increased AF duration [13] . Increased levels of proinflammatory cytokines (IL-1β, CCL2, CXCL1/2, IFN-γ) and fibrosis-related molecules (COL1A1, αSMA, TGF-β) were associated with atrial electrical remodeling, connexin down-regulation, and atrial arrhythmogenicity [14] , [15] . Inflammation-resolution promoting interventions with specialized pro-resolving mediators (resolvins, maresins, protectins) have the potential to promote cessation of proinflammatory signals to prevent arrhythmogenic fibrosis [3] , [15] ( Fig.…”

Section: Evidence Of Profibrillatory Inflammation-signaling In Afmentioning

confidence: 99%

Cardiac cytokine therapy? Relevance of targeting inflammatory mediators to combat cardiac arrhythmogenic remodeling

Hiram

2021

IJC Heart & Vasculature

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“…Classically, Th1 cells that produce IFN-g and IL-2 might play a substantial role in the synovial fluid and peripheral blood during the development of RA. The peripheral blood of patients with RA contains citrulline-specific T cells, of which ~40% of the samples are positive for the Th1 marker chemokine receptor 3 (CXCR3) (21), and plasma concentrations of IL-2 and IFN-g, which are also biomarkers of Th1 cells, are significantly elevated in patients with AF (13,22,23). Among them, IL-2 activates T lymphocytes and stimulates the synthesis of TNF-a and IFN-g, both of which exert biological effects that might promote atrial remodeling through macrophages via stimulating cytokine secretion.…”

Section: Discussionmentioning

confidence: 99%

“…A disabled ANS is a considerable reason for triggering ectopic pacemakers in AF. Furthermore, elevated Th1 cells produce more IFN-g to activate resident cardiac macrophages (22), which in turn produce tumor necrosis factor (TNF)-a and IL-1b, both of which can damage cardiac myocytes (37). There is considerable evidence supporting that macrophages play a core role in promoting electrical and structural remodeling by altering Ca 2+ handling, shortening the action potential duration, reducing Cx40 and Cx43, causing fibrosis, and generating cardiac myocyte apoptosis and myolysis during the progress of AF (38).…”

Section: Discussionmentioning

confidence: 99%

Elevated Peripheral T Helper Cells Are Associated With Atrial Fibrillation in Patients With Rheumatoid Arthritis

et al. 2021

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Patients with rheumatoid arthritis (RA) have a significantly high risk of atrial fibrillation (AF). This study aimed to compare the absolute and relative changes in peripheral T cells in patients with RA who were also affected with and without AF. To help make an early diagnosis and prevent the initiation and progression of AF, the changes in the lymphocyte subsets were assessed in RA patients with and without AF. A propensity score matching (PSM) system (1:3) was used to perform a matched case-control study with 40 RA-AF cases and 120 RA controls. Changes in the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-citrullinated peptide antibody (ACPA), and rheumatoid factor (RF) were examined. The percentage and absolute number of T, B, natural killer (NK), T helper (Th)1, Th2, Th17, and T-regulatory (Treg) cells in the peripheral blood of patients with and without RA-AF were determined using flow cytometry. Univariate and multivariate analyses were performed to determine the association between peripheral lymphocytes and RA-AF. Demographic data, ESR, CRP, ACPA, and the percentage, as well as the absolute value of B, NK, Th2, and Treg cells, showed no significant differences between the propensity score-matched groups of RA and RA-AF. Meanwhile, the absolute number and percentage of Th1 cells, the absolute number of Th17 cells, the ratio of Th1/Treg, Th17/Treg, and RF were significantly higher in patients with RA-AF than those in the control groups (P < 0.05). Univariate and multivariate logistic regression analyses also revealed that the percentage of Th1 cells, the absolute number of Th17 cells, and the ratio of Th1/Treg were associated with a significantly higher risk of AF. This PSM study demonstrated that the incidence of AF was higher in RA patients with Th cell immunological derangements.

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Plasma Level of Interferon-γ Predicts the Prognosis in Patients With New-Onset Atrial Fibrillation

Cited by 10 publications

References 37 publications

Atrial fibrillation in COVID‐19: A review of possible mechanisms

Atrial fibrillation in COVID‐19: A review of possible mechanisms

Cardiac cytokine therapy? Relevance of targeting inflammatory mediators to combat cardiac arrhythmogenic remodeling

Elevated Peripheral T Helper Cells Are Associated With Atrial Fibrillation in Patients With Rheumatoid Arthritis

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