Plasma level of myeloperoxidase in children with juvenile idiopathic arthritis (a pilot study)

Pruunsild, Chris; Heilman, Kaire; Zilmer, Kersti; Uibo, Karin; Liivamägi, Hille; Talvik, Tiina; Zilmer, Mihkel; Tillmann, Vallo

doi:10.2478/s11536-009-0107-5

Cited by 4 publications

(5 citation statements)

References 16 publications

(16 reference statements)

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“…Several studies have shown that increased MPO concentration is associated with an increased risk of CVD [ 27 , 28 ]. Also, studies have shown higher serum and plasma concentrations in patients with rheumatologic diseases [ 9 , 29 ]. In our study, we found higher serum levels of MPO in patients with JIA already at an early stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis

et al. 2015

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IntroductionJuvenile idiopathic arthritis (JIA) is a frequent childhood rheumatic disease characterized by chronic inflammation. The latter has been related to impairment of arterial functional-structural properties, atherogenesis and later cardiovascular events. The objective of this study was to examine intima-media thickness (IMT) and the parameters of arterial stiffness in children with JIA at diagnosis and their correlation with JIA subtype and markers of inflammation and atherosclerosis.MethodsThirty-nine newly diagnosed patients with JIA (26 girls; mean age, 13.2 ± 2.6 years) and 27 healthy controls (9 girls; mean age, 13.6 ± 3.4 years) were included in the study. Twelve patients had oligoarthritis, fifteen had extended oligoarthritis and twelve had rheumatoid factor–negative polyarthritis. IMT of the common carotid artery was determined by ultrasonography, carotid-femoral pulse wave velocity (cfPWV) and augmentation index adjusted to a heart rate of 75 beats/min (AIx@75) were determined by applanation tonometry. The serum levels of atherosclerosis-related biomarkers, such as asymmetric dimethylarginine (ADMA), myeloperoxidase (MPO) and adiponectin, were measured by enzyme-linked immunosorbent assay.ResultsMean IMT (0.46 ± 0.04 vs. 0.42 ± 0.04 mm; p = 0.0003) and MPO concentration (115.2 [95 % confidence interval {95 % CI}, 97.4–136.3] vs. 57.6 [95 % CI, 47.1–70.3] ng/ml; p < 0.0001) were higher in the patients with JIA than in the control subjects. The cfPWV, AIx@75 and serum ADMA and adiponectin levels did not significantly differ between the groups and JIA subtypes. Serum adiponectin level correlated negatively with AIx@75 in patients with JIA (r = −0.38; p < 0.05).ConclusionsPatients with JIA have increased mean IMT and elevated MPO levels at early stages of the disease. AIx@75 was inversely independently associated with adiponectin level in the patients, suggesting that lower adiponectin levels might influence arterial subclinical stiffening in patients with newly diagnosed JIA.

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Section: Discussionmentioning

confidence: 99%

“…MPO, ADMA and adiponectin have been linked to inflammation and/or oxidative stress [ 6 – 8 ]. Previous studies have shown that MPO levels are higher in patients with JIA compared with control groups [ 9 ]. ADMA and adiponectin have not been investigated in patients with JIA.…”

Section: Introductionmentioning

confidence: 99%

Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis

et al. 2015

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“…More, FRs directly contribute to the degradation of collagen, depolymerization of hyaluronic acid and disturbance of the synthesis of proteoglycan core proteins [ 30 ]. The hypothesis regarding the increased free radical activity characterizing JIA patients is confirmed by the increased levels of oxidative stress markers, i.e., the products of lipid or protein peroxidation, circulating in the blood of the patients, which has been demonstrated by other researchers [ 16 , 17 , 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 70%

“…TGF-β may additionally act as a stimulator of the inflammatory process as well as synovial hyperplasia and fibrosis [ 38 ]. The discussed cytokine stimulates the synthesis of proinflammatory cytokines, including IL-1 and TNF-α, by the cells of the synovial membrane [ 32 ]. Hence, the pathways of ECM transformation dependent on the discussed factor are not unidirectional and are related to its concentration [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma Concentrations in Patients with Juvenile Idiopathic Arthritis

Kuźnik-Trocha

Winsz-Szczotka

Lachór-Motyka³

et al. 2022

JCM

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We assessed the effect of 24-month anti-tumor necrosis factor alpha (TNF-α) treatment on the remodeling of the cartilage extracellular matrix (ECM) in patients with juvenile idiopathic arthritis (JIA). Methods: Quantitative evaluation of keratan sulfate (KS), hyaluronic acid (HA), hyaluronan and proteoglycan link protein 1 (HAPLN1), as potential biomarkers of joint dysfunction, and the levels of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 4 and 5, total oxidative status (TOS) and transforming growth factor (TGF-β1) was performed (using immunoenzymatic methods) in blood obtained from patients before and after 24 months of etanercept (ETA) treatment. Results: When compared to the controls, KS, HA and HAPLN1 levels were significantly higher in patients with an aggressive course of JIA qualified for ETA treatment. An anti-cytokine therapy leading to clinical improvement promotes the normalization only of the HA level. Proteolytic and pro-oxidative factors, present in high concentrations in patients before the treatment, correlated with HAPLN1, but not with KS and HA levels. In these patients, negative correlations were found between the levels of TGF-β1 and KS, HA and HAPLN1. Conclusion: The anti-TNF-α therapy used in patients with JIA has a beneficial effect on ECM cartilage metabolism, but it does not completely regenerate it. The changes in the plasma HA level during the anti-cytokine therapy suggest its potential diagnostic utility in monitoring of disease activity and may be used to assess the efficacy of ETA treatment.

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“…Children with JIA have higher plasma MPO levels than healthy. In the group of patients with the arthropathy the highest concentration of MPO is observed in children with polyarticular JIA [98,99].…”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 93%

Alterations of Extracellular Matrix Components in the Course of Juvenile Idiopathic Arthritis

2021

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Juvenile idiopathic arthritis (JIA) is the most common group of chronic connective tissue diseases in children that is accompanied by joint structure and function disorders. Inflammation underlying the pathogenic changes in JIA, caused by hypersecretion of proinflammatory cytokines, leads to the destruction of articular cartilage. The degradation which progresses with the duration of JIA is not compensated by the extent of repair processes. These disorders are attributed in particular to changes in homeostasis of extracellular matrix (ECM) components, including proteoglycans, that forms articular cartilage. Changes in metabolism of matrix components, associated with the disturbance of their degradation and biosynthesis processes, are the basis of the progressive wear of joint structures observed in the course of JIA. Clinical evaluation and radiographic imaging are current methods to identify the destruction. The aim of this paper is to review enzymatic and non-enzymatic factors involved in catabolism of matrix components and molecules stimulating their biosynthesis. Therefore, we discuss the changes in these factors in body fluids of children with JIA and their potential diagnostic use in the assessment of disease activity. Understanding the changes in ECM components in the course of the child-hood arthritis may provide the introduction of both new diagnostic tools and new therapeutic strategies in children with JIA.

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Plasma level of myeloperoxidase in children with juvenile idiopathic arthritis (a pilot study)

Cited by 4 publications

References 16 publications

Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis

Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis

The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma Concentrations in Patients with Juvenile Idiopathic Arthritis

Alterations of Extracellular Matrix Components in the Course of Juvenile Idiopathic Arthritis

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