Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure

Abstract

Background/Aim: Elevated plasma concentration of retinol-binding protein 4 (RBP4) has recently emerged as a potential new risk factor for cardiovascular diseases, including hypertension (HT) and coronary artery disease (CAD). Limited data suggest that RBP4 promotes inflammatory damage to cardiomyocytes and participates in the development of heart failure (HF). This study aimed to analyze the relationship between concentrations of plasma RBP4 and serum N-terminal proBNP (NT-proBNP), a powerful biomarker of left ventricle dysfunction, in the older Polish population. Methods: The study sample consisted of 2,826 (1,487 men) participants of the PolSenior study, aged 65 years and older, including a subgroup hospitalized for HF (n = 282). In all subjects, plasma concentrations of RBP4, interleukin-6 (IL-6), serum level of NT-proBNP, and hs-CRP were measured. Additionally, BMI, estimated glomerular filtration rate (eGFR), and HOMA-IR were calculated. The prevalence of HT, CAD, atrial fibrillation (AF), and medication were considered as potential confounders. Results: Similar RBP4 levels were found in subjects with NT-proBNP < 125 and ≥125 ng/mL, with and without AF, and in the subgroups hospitalized for HF with and without AF. Regression analysis revealed no association between log₁₀(NT-proBNP) and log₁₀(RBP4). Plasma levels of RBP4 were increased by HT occurrence and diuretic therapy, while diminished with regard to female gender, age, eGFR values, AF, and IL-6 levels. Conclusion: Our results show that RBP4 is affected by GFR but cannot be considered as an independent biomarker of heart muscle dysfunction.

Serum retinol‐binding protein 4 as a predictor of cardiovascular events in elderly patients with chronic heart failure

“…The results are consistent with a previous study showing that serum RBP4 levels were increased in patients with advanced heart failure and remarkably decreased in response to mechanical unloading and hemodynamic correction after the implantation of left ventricular assist device . However, another study of elderly subjects found no significant differences of plasma RBP4 levels between subjects with low levels (<125 ng/mL) and high levels (≥125 ng/mL) of NT‐proBNP, as well as subjects with and without a history of hospitalization for heart failure . Moreover, no relationship was observed between the levels of RBP4 and NT‐proBNP in their study .…”

“…However, another study of elderly subjects found no significant differences of plasma RBP4 levels between subjects with low levels (<125 ng/mL) and high levels (≥125 ng/mL) of NT‐proBNP, as well as subjects with and without a history of hospitalization for heart failure . Moreover, no relationship was observed between the levels of RBP4 and NT‐proBNP in their study . The discrepancies might partly attribute to the heterogeneity in study design.…”

“…The discrepancies might partly attribute to the heterogeneity in study design. Our study population was restricted to elderly patients who were hospitalized for heart failure, while the study of Majerczyk et al . was a community‐based study composed of both CHF patients and subjects with normal cardiac function.…”

New insights into different adipokines in linking the pathophysiology of obesity and psoriasis

“…RBP4, an adipokine which predominantly secreted by adipocytes, macrophages and hepatocytes, was first discovered in 2005 [105, 106]. Especially, RBP4 is produced by the visceral adipocytes under the status of obesity and insulin resistance.…”

Relationship between oxidative stress and nuclear factor‑erythroid‑2‑related factor 2 signaling in diabetic cardiomyopathy (Review)

“…Early diastolic dysfunction is usually characterized by decreased myocardial compliance and blocked diastolic filling ( 2 ). Late diastolic dysfunction is mainly manifested as congestive heart failure (HF) ( 3 ). DCM is one of the main complications of DM, differing from hypertension and other types of cardiovascular disease, which demonstrates one of the highest incidence rates of all cardiovascular diseases with an incidence rate of 16.9% in China ( 4 ).…”