Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer

Gey, K. F.; Brubacher, G.; Stähelin, H B

doi:10.1093/ajcn/45.5.1368

Cited by 406 publications

(114 citation statements)

References 15 publications

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“…The possible benefits of this approach are suggested by the negative correlation between coronary heart mortality and plasma vitamin E and vitamin C levels (Gey et al, 1987;Riemersma et al, 1991). The obvious strategies are to increase dietary intakes or to give antioxidant supplements.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress status in patients with diabetes mellitus: relationship to diet

et al. 2003

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Objective: To investigate the relationship between dietary intakes and in vivo oxidative stress (OS) status in diabetic patients. Design: Case-control study. Setting: Outpatient-Clinic and Laboratory Endocrinology, University Antwerp. Subjects and methods: A total of 30 patients (24 type 1 diabetes mellitus (T1DM)/6 type 2 diabetes mellitus (T2DM) were asked to complete a 2 weekdays+1weekend day food consumption questionnaire during the week preceding their yearly diabetes control consultation, when samples were collected for the assay of oxidative stress (OS) (blood levels of antioxidants, peroxides, malondialdehyde (MDA) and minerals). Blood samples were also collected from 25 age-and sex-matched healthy controls. Results: Diabetic patients had lower glutathione (5.8071.15 vs 6.7571.03 mmol/g Hb in the controls, P ¼ 0.002) and higher MDA (0.68770.212 vs 0.54570.101 mmol/l, P ¼ 0.002). Although the group average intakes were within the Belgian RDA, intakes of fat 435% energy, fibre o15 g/1000 kcal, fruit o2 portions and vitamin E o10 mg/day were seen in more than 20 patients. Blood antioxidants did not correlate with intakes of energy, fat, protein or fibres or of their respective antioxidant. Vitamins A and E correlated with serum lipids (r ¼ 0.58, P o0.0005 between serum a-tocopherol and cholesterol). Blood peroxide levels were only related to intakes of saturated fat and cholesterol (Po0.05). In diabetic subjects but not in controls (Po0.05) MDA was related to glutathione and uric acid. Conclusions: In diabetic patients, blood levels of antioxidants are not related to their dietary intakes but to serum lipids. Levels of oxidative damage products are only related to intakes of saturated fats and cholesterol and to levels of endogenous antioxidants.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress status in patients with diabetes mellitus: relationship to diet

et al. 2003

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“…In addition, the changes in peroxidation rates in plasma LDL, once depleted of antioxidant content, can be related to their fatty acid pattern. This hypothesis is also supported by many world-wide epidemiological studies that associate vegetable-rich or Mediterranean diets with a higher life expectancy, and antioxidants could be of prime importance in the bene®cial effects of these diets (Gey et al, 1987, Gey & Puska, 1989Gey et al, 1992;Riemersma et al, 1991). In addition, the plasma status of vitamin E has always been the strongest predictor of the up-to-six fold differences of CHD in European study populations (Gey et al, 1987;Gey & Puska, 1989;Gey et al, 1992).…”

Section: Discussionmentioning

confidence: 70%

Comparison of an oleic acid enriched-diet vs NCEP-I diet on LDL susceptibility to oxidative modifications

et al. 2000

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Objective: The objective of this trial was to compare the effect on the susceptibility of plasma Low Density Lipoprotein (LDL) to oxidative modi®cations of consumption of two oleic rich diets, prepared with two different plant oils, virgin olive oil (OL) 1 and re®ned high monounsaturated fatty acids (MUFA sun¯ower oil (SU)), with the susceptibility of plasma LDL to oxidation after an National Cholesterol Education Program step 1 (NCEP-I) phase diet. Design: A randomized crossover design. Subjects and interventions: Twenty-two healthy normolipidemic young males consumed an NCEP-I diet for a 4-week period. Subjects were then assigned to two diets each of 4-weeks duration. Group one was placed on an olive oil enriched diet (40% fat, 22% MUFA) followed by a 4-week period of a MUFA diet enriched in sun¯ower oil (40% fat, 22% MUFA). In group two, the order of the diets was reversed. Results: Both MUFA diets induced a decrease in saturated (14 : 0, 16 : 0, and 18 : 0) and an increase in monounsaturated and polyunsaturated n-6 (18 : 2, 20 : 3, and 20 : 5) plasma LDL-phospholipid fatty acids, compared to the NCEP-I diet (P`0.01). No signi®cant differences in lag times were observed between the olive oil and the NCEP-I diet periods. However there was a greater inhibition time (P`0.001) when subjects consumed the MUFA rich sun¯ower oil diet compared to the NCEP-I diet. These differences were probably related to the relative enrichment of plasma LDL particles in a-tocopherol due to the high vitamin E content of the MUFA-rich sun¯ower oil. Indeed, the a-tocopherol content was positively correlated with lag time (r 0.338; P`0.008). Conclusion: Our ®ndings suggest that changes in plasma LDL a-tocopherol content with practical solid-food diets can decrease its susceptibility to oxidation. Sponsorship: This work has been supported by grants from the Investigaciones de la Seguridad Social (FIS 92a0182, to Francisco Pe Ârez Jime Ânez); and from Koype Co, Andu Âjar, Jae Ân, Spain. Descriptors: oxidized low density lipoproteins; a-tocopherol; phospholipid; monounsaturated fatty acids; low fat diets; fatty acids

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“…Low serum levels of vitamin E have been associated with increased risk of breast cancer (Wald et al, 1984), lung cancer (Menkes et al, 1986) and gastrointestinal cancer (Gey et al, 1987), but there have also been reports showing no significant association (Heinonen et al, 1987;Nomura et al, 1985;Russell et al, 1988) or even a direct association for breast cancer (Gerber et al, 1988). To our knowledge only one other study has measured vitamin E levels in women with CIN.…”

mentioning

confidence: 94%

Vitamin A, vitamin E and the risk of cervical intraepithelial neoplasia

Cuzick

Stavola²,

Russell³

et al. 1990

Br J Cancer

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Epidemiological studies have suggested that deficiencies in the consumption of preformed vitamin A or its precursor P-carotene may increase the risk of cervical cancer and cervical intraepithelial neoplasia (CIN) (Romney et al., 1981;Marshall et al., 1983;La Vecchia et al., 1984). More recent studies of blood samples have failed to show a relationship between low serum levels of vitamins A and cervical cancer but an association has been found for P-carotene especially in women with pre-invasive disease (Harris et al., 1986;Heinonen et al., 1987;Brock et al., 1988;Palan et al., 1988). Vitamin E has been little studied in relation to cervix cancer. An inverse relation has been reported in one study (Knekt, 1988) but not another (Heinonen et al., 1987).We have examined serum levels of vitamin A and vitamin E in young women aged Sera were analysed blindly for vitamin A and vitamin E according to the procedure of Russell et al. (1986). Antioxidant (BHT) was added prior to extraction to ensure that both vitamins A and E were stable after prolonged storage (Russell et al., 1986). A trend in levels across the three groups was examined by the Wilcoxon test for trend (Cuzick, 1985). Odds ratios for the risk of CIN I and CIN III were

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Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer

Cited by 406 publications

References 15 publications

Oxidative stress status in patients with diabetes mellitus: relationship to diet

Oxidative stress status in patients with diabetes mellitus: relationship to diet

Comparison of an oleic acid enriched-diet vs NCEP-I diet on LDL susceptibility to oxidative modifications

Vitamin A, vitamin E and the risk of cervical intraepithelial neoplasia

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