Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases

Abstract

The progressive increase of ADMA levels described by our study among preterm infants suggests that early endothel dysfunction may take part in developmental programming of chronic adult diseases.

Simultaneous quantitative determination of NG,NG-dimethyl-l-arginine or asymmetric dimethylarginine and related pathway's metabolites in biological fluids by ultrahigh-performance liquid chromatography/electrospray ionization-tandem mass spectrometry

“…ADMA, SDMA and NMMA in plasma and serum were higher than in adults, as recently reported by Vida et al [52], suggesting that this increase could be come from of postnatal adaptation at birth. Instead of Table 3 Inter-and intra-assay precision in plasma and urine.…”

Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?

“…The close inverse correlation observed between ADMA and gestational age suggests that the high degree of NO inhibition is likely related to immaturity at birth of preterm ex-ELBW, thereby confirming the few reports present in literature focusing on sensitivity of ADMA and degree of neonatal maturity [15,19]. On the other hand, the findings of this study provide the first evidence that the potentially dysfunctional condition continues into adulthood.…”

“…However, a single, recent study detected significantly higher levels of ADMA in the first month of life in preterm infants than in babies born at term. The authors hypothesize that this very early endothelial dysfunction may be implicated in developmental programming of future cardiovascular morbidity [15].…”

“…A recent study conducted on ELBW and very low birth weight (i.e. having a birth weight between 1001 and 1500 g) infants, demonstrated the presence of elevated ADMA levels during the first month of life (controls at 3-7-14-21-28 days), suggesting the presence of an early endothelial dysfunction, which could be a prelude to the development of chronic diseases in adulthood [15].…”

Is Asymmetric Dimethylarginine Associated with Being Born Small and Large for Gestational Age?

“…In addition, a growing number of studies indicate a perturbation of the ADMA-NO pathway even in a perinatal setting. Vida et al detected a progressive increase of ADMA levels in preterm infants during the first month of life, suggesting that early endothelial dysfunction may take part in the developmental programming of chronic adult diseases (9). Nevertheless, up to now, studies assessing ADMA levels have been limited to term and preterm SGA newborns (6), while no data are available in the LGA population.…”