Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates

Kalaycı, Dilek; Dikmen, Bayazıt; Kaçmaz, Murat; Taspinar, Vildan; Ornek, Dilsen; Turan, Özlem

doi:10.1016/j.bjane.2013.06.008

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…Desflurane produces more pro-inflammatory responses compared to sevoflurane ( 39 ). Kalayci et al ( 7 ) evaluated the plasma level of IL-10 in response to desflurane with two different flow rates. The results showed that the plasma concentration of IL-10 at the end of surgery and 24-hours later was significantly higher compared to the start of surgery.…”

Section: Resultsmentioning

confidence: 99%

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General Anesthetics on Immune System Cytokines: A Narrative Review Article

et al. 2020

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Context: According to the previous studies, general anesthesia influences the immune system. Evaluating such impacts on the immune system helps to improve the management of anesthesia. Evidence Acquisition: The current review aimed to summarize the literature related to the effects of general anesthesia agents on the cytokines. Google Scholar, PubMed, and ISI/Web of Sciences databases were searched using the following keywords: cytokine, general anesthesia, immune response, intravenous anesthesia, volatile anesthetics, opioids, benzodiazepines, and controlled ventilation. Results: Long-term administration of general anesthesia drugs, due to their effects on cytokines, can lead to disease progression in patients with immune deficiency. Due to the conflicting results of various studies and the increasing number of patients with immune deficiency, the choice of the appropriate general anesthesia agents facilitates achieving the more favorable function of the cytokines. Conclusions: It seems that the effect of general anesthesia on the immune system in healthy patients and short-term surgeries is not considerable and changes in the immune system are related to surgical trauma, particularly in major surgery.

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Section: Resultsmentioning

confidence: 99%

“…Cytokines are key modulators of inflammation that play both inflammatory and anti-inflammatory roles. Cytokines contribute to the removal of antigens and play a key role in the drugs and systemic inflammatory responses ( 7 , 8 ).…”

Section: Contextmentioning

confidence: 99%

General Anesthetics on Immune System Cytokines: A Narrative Review Article

et al. 2020

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“…However, Kalaycı et al reported that there was not a significant difference in the IL10 levels between the low-flow and highflow desflurane anesthesia [16,25].…”

Section: Discussionmentioning

confidence: 96%

The effect of minimal-flow inhalational anesthesia on peak expiratory flow rate

Gürsul,

Aytaç,

Aytaç

et al. 2021

Ann Clin Anal Med

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Aim: In this study, we aimed to compare the effects of minimal (500 mL/min) and high-flow (3000 mL/min) anesthesia on the respiratory system by evaluating the peak expiratory flow rate (PEFR) and the ventilation pressure. Material and Method: Forty ASA I-II patients undergoing elective middle ear microsurgery under minimal and high-flow desflurane anesthesia were evaluated for the PEFR in the preoperative and the postoperative 1st, 6th, 24th hours. Intraoperative hemodynamic parameters, ventilation pressures and the duration of extubation were also evaluated. Results: There were no significant differences between the groups in terms of demographic characteristics. The duration of operation, anesthesia and extubation, intraoperative peak and plateau pressure, SpO2%, heart rate, end-tidal desflurane, MAC, and FiO2 were similar. In the minimal flow anesthesia group, the MAP (69.40±6.21 mmHg) was significantly higher than in the patients receiving high-flow (61.70±4.39 mmHg) anesthesia (p<0.001). The difference between PEFR values measured at four different time points was statistically significant (time; F (3.38) = 29.696, p<0.001). The PEFR value in the postoperative 1st hour was statistically significantly lower compared to the preoperative levels and the levels measured in the postoperative 6th and 24th hours. The PEFR values of the patients in the high-flow and minimal-flow anesthesia groups were not statistically significantly different (Group; F(1.38) = 0.623, p>0.05). Discussion: The effects of minimal (500 mL/min) and high-flow (3000 mL/min) anesthesia on the respiratory system were compared by PEFR and ventilation pressure showing similar results. With the current technological advances, the use of minimal-flow anesthesia combined with an effective follow-up period may have favorable effects.

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“…As Kelley et al [ 29 ], the NLRP3 inflammasome can be activated by a multitude of stimuli, the activation of NLRP3 inflammasomes being a mechanism of self-defense against invasive factors and stress. The activation of NLRP3 results in the production of proinflammatory cytokines, cytokines having a key role in the action of anesthetic drugs and for systemic inflammatory responses [ 30 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

Novac

Boldeanu²,

Rotaru³

et al. 2022

Rom J Morphol Embryol

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Background : The specific mechanism of action of each anesthetic drug on the immune system is still incompletely known. It is important to know how the various anesthetics used in minimally invasive surgery (MIS) act on the inflammatory response because the choice of the anesthetic agent can influence the patient’s immune system. Aim : Evaluation of the effect of anesthetic drugs used for total intravenous anesthesia (Propofol and Midazolam) on the inflammatory response after minimally invasive gynecological surgery. Patients, Materials and Methods : The inflammatory response in 20 female patients who underwent minimally invasive gynecological surgery under which intravenous anesthesia was performed. Depending on the combination of anesthetics used, we subdivided the study group into two groups, Group 1 consisting of the patients ( n =10) who were given for total intravenous anesthesia, the combination with Midazolam+Fentanyl, and Group 2 ( n =10) the patients who received the combination of Propofol+Fentanyl, respectively. Surgical interventional procedures included day surgery: diagnostic and operative hysteroscopy, endometrial ablation, surgical treatment of vulvar disorders. Serological profiling of patients was performed by dosing the serum concentration of nucleotide-binding domain (NOD) and leucine-rich repeat protein 3 (NLRP3) inflammasomes, interleukin (IL)-6, tumor necrosis factor-alpha (TNF- α ), IL-10 before and two hours after the surgical procedure. Results : In our study, we found that in both groups of patients (Midazolam+Fentanyl – Group 1, Propofol+Fentanyl – Group 2), NLRP3 and cytokines concentrations in the serum were higher after MIS than those before MIS. Conclusions : It appears that both Midazolam and Fentanyl and Propofol and Fentanyl have an immunomodulatory action due to the anti-inflammatory effect of both anesthetics. Therefore, anesthesiologists must choose an anesthetic method that uses individualized anesthetic agents, depending on the patient’s immune status and disease.

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Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates

Cited by 7 publications

References 38 publications

General Anesthetics on Immune System Cytokines: A Narrative Review Article

General Anesthetics on Immune System Cytokines: A Narrative Review Article

The effect of minimal-flow inhalational anesthesia on peak expiratory flow rate

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

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