Plasma levels of neuropeptide tyrosine Y (NPY) are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations

Watson, Joe; Sury, Michael R. J.; Corder, Roger; Carson, Robert P.; Bouloux, Pierre‐Marc; Lowry, P. J.; Gm, Besser; Hinds, C. J.

doi:10.1677/joe.0.1160421

Cited by 24 publications

(7 citation statements)

References 26 publications

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“…(1987) also reported in rats that the sympathetic nerves were mainly responsible for the increases in plasma NPY conwntmtion after activation of the sympathoadred system by hemorrhagic stress, since chemical sympathectomy, but not adrena&ctomy, abolished the elevations in NPY levels during that manoeuvre. More recently, Watson et d. (1988) 7). Stimulation frequency was raised stepwise fmm 1 (SI), 3 (S3), and 10 (S10) Hz at 3-min intervals during the 9-min stimulation period.…”

Section: Discussionmentioning

confidence: 99%

Corelease of neuropeptide Y like immunoreactivity with catecholamines from the adrenal gland during splanchnic nerve stimulation in anesthetized dogs

Briand

Yamaguchi²,

Gagné³

et al. 1990

Can. J. Physiol. Pharmacol.

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The release of neuropeptide Y like immunoreactivity (NPY-li) from the adrenal gland was studied in relation to the secretion of catecholamines (CA: NE, norepinephrine; E, epinephrine) during the left splanchnic nerve stimulation in thiopental-chloralose anesthetized dogs (n = 16). Plasma concentrations of NE, E, and NPY-li were determined in the left adrenal venous and aortic blood. Adrenal outputs of NPY-li, NE, and E were 2.4 +/- 0.4, 1.4 +/- 0.2, and 7.3 +/- 1.7 ng/min, under basal conditions, respectively. These values increased significantly (p less than 0.05; n = 8) in response to a continuous stepwise stimulation at frequencies of 1, 3, and 10 Hz given at 3-min intervals during 9 min, reaching a maximum output of 4.6 +/- 0.9 (NPY-li), 240.2 +/- 50.2 (NE), and 1412.5 +/- 309.7 ng/min (E) at a frequency of 10 Hz. Burst electrical stimulation at 40 Hz for 1 s at 10-s intervals for a period of 10 min produced similar increases (p less than 0.05) in the release of NPY-li (4.8 +/- 1.0 ng/min, n = 8), NE (283.5 +/- 144.3 ng/min, n = 8), and E (1133.5 +/- 430.6 ng/min, n = 8). Adrenal NPY-li output was significantly correlated with adrenal NE output (r = 0.606; n = 24; p less than 0.05) and adrenal E output (r = 0.640; n = 24; p less than 0.05) in dogs receiving the burst stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Corelease of neuropeptide Y like immunoreactivity with catecholamines from the adrenal gland during splanchnic nerve stimulation in anesthetized dogs

Briand

Yamaguchi²,

Gagné³

et al. 1990

Can. J. Physiol. Pharmacol.

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“…NPY is a peptide that co-localizes with other neurotransmitters in nerve terminals. The peptide plays a role in the pathophysiology of chronic diseases and a high plasma level is observed in patients with septicaemia [22]. Increased amounts of NPY can cause pulmonary hypertension and bronchoconstriction.…”

Section: Discussionmentioning

confidence: 99%

Levels of vasodilators (SP, CGRP) and vasoconstrictor (NPY) peptides in early human burns

Onuoha

Alpar

2001

Eur J Clin Investigation

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An intact nociceptor system of primary afferent sensory nerves is important for the initiation of the inflammatory process and successful tissue repair. Dysfunction of this system could be a contributing factor for delayed wound healing in humans. We examined the levels of vasodilators [substance P (SP), calcitonin gene-related peptide (CGRP)] and a vasoconstrictor peptide [neuropeptide Y (NPY)] in the peripheral blood samples of patients with burns covering from 20 to 75% of body surface area. Thirteen patient samples were obtained immediately on admission (OA), which was within 12 h of the thermal injury, and 24 h post-admission (PA). Enzyme immunoassay techniques were used for the measurement of the neuropeptides. In addition, an inflammatory marker, tumour necrosis factor-alpha (TNF-alpha), and a myofibrillar protein, creatine kinase (CK), were examined and compared with levels in 13 control subjects. CGRP was high OA and the levels were maintained PA (P < 0.05). SP was also significantly high at both sampling times (P < 0.05). Although TNF-alpha and NPY were somewhat higher in the patients' samples than in the control samples, these levels were not statistically significant (P = NS). CK was higher OA (P < 0.01) than PA (P < 0.04), compared to controls. Plasma levels of SP and CGRP increased significantly in patients with thermal injuries. These peptides may yet be another group of neuromodulators playing a significant role in immune, pain, inflammatory and wound healing in burns.

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“…Furthermore, the vasopressive properties of NPY as well as its capacity to potentiate adrenergic responsiveness led to the suggestion that this peptide might be beneficial in the management of endotoxic shock. Indeed, in humans experiencing sepsis and septic shock, plasma levels of NPY are significantly increased [151,152], and NPY-mediated vasoconstriction was shown to be preserved during endotoxemia [153]. NPY infusion is able to prevent the development of hypotension and restore the response to pressor agents in endotoxemic rats at doses that do not affect blood pressure [153].…”

Section: Npy and Blood Pressure Homeostasismentioning

confidence: 99%

Neuropeptide Y: the universal soldier

Pedrazzini¹,

Pralong

Grouzmann³

2003

Cellular and Molecular Life Sciences (CMLS)

253

158

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The peptidic neuropeptide Y (NPY) has received great attention because it has been implicated in the regulation of several organ systems. In particular, NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. Furthermore, NPY exerts vasoconstrictive action on the vasculature and potentiates the actions of many other vasoconstrictors. In addition, it was demonstrated to have trophic properties and could therefore contribute to cardiovascular remodeling. These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.

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Plasma levels of neuropeptide tyrosine Y (NPY) are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations

Cited by 24 publications

References 26 publications

Corelease of neuropeptide Y like immunoreactivity with catecholamines from the adrenal gland during splanchnic nerve stimulation in anesthetized dogs

Corelease of neuropeptide Y like immunoreactivity with catecholamines from the adrenal gland during splanchnic nerve stimulation in anesthetized dogs

Levels of vasodilators (SP, CGRP) and vasoconstrictor (NPY) peptides in early human burns

Neuropeptide Y: the universal soldier

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