Plasma levels of retinoids, carotenoids and tocopherols in patients with mild obstructive sleep apnoea

Day, Regina M.; Matus, Ismael; Suzuki, Yuichiro; Yeum, Kyung‐Jin; Qin, Jian Xin; Park, Ah-Mee; Jain, Vivek; Kuru, Tünay; Tang, Guangwen

doi:10.1111/j.1440-1843.2009.01623.x

Cited by 13 publications

(10 citation statements)

References 46 publications

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“…In contrast, this association was found specifically for obstructive sleep apnea and restless leg syndrome in two previous studies [21] , [22] . In contrast to our findings, Day and colleagues [20] found that patients with obstructive lung apnea, as compared to controls, had lower serum levels of retinyl palmitate and 9-cis retinoic acid, as well as lower levels of all-trans-β-carotene and 9-cis-β-carotene. Moreover, low serum folate has been associated with restless leg syndrome among pregnant women [23] .…”

Section: Discussioncontrasting

confidence: 99%

“… [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] ). Despite this trend, and the known association between sleep and cognitive as well as affective disorders [15] , [16] , [17] , limited epidemiological research has explored how sleep quantity and quality may be related to serum nutritional biomarkers [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] .…”

Section: Introductionmentioning

confidence: 99%

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Serum Nutritional Biomarkers and Their Associations with Sleep among US Adults in Recent National Surveys

et al. 2014

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BackgroundThe associations between nutritional biomarkers and measures of sleep quantity and quality remain unclear.MethodsCross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2005–2006 were used. We selected 2,459 adults aged 20–85, with complete data on key variables. Five sleep measures were constructed as primary outcomes: (A) Sleep duration; (B) Sleep disorder; (C) Three factors obtained from factor analysis of 15 items and labeled as “Poor sleep-related daytime dysfunction” (Factor 1), “Sleepiness” (Factor 2) and “Sleep disturbance” (Factor 3). Main exposures were serum concentrations of key nutrients, namely retinol, retinyl esters, carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, lycopene), folate, vitamin B-12, total homocysteine (tHcy), vitamin C, 25-hydroxyvitamin D (25(OH)D) and vitamin E. Main analyses consisted of multiple linear, logistic and multinomial logit models.ResultsAmong key findings, independent inverse associations were found between serum vitamin B-12 and sleep duration, 25(OH)D and sleepiness (as well as insomnia), and between folate and sleep disturbance. Serum total carotenoids concentration was linked to higher odds of short sleep duration (i.e. 5–6 h per night) compared to normal sleep duration (7–8 h per night).ConclusionsA few of the selected serum nutritional biomarkers were associated with sleep quantity and quality. Longitudinal studies are needed to ascertain temporality and assess putative causal relationships.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Nutritional Biomarkers and Their Associations with Sleep among US Adults in Recent National Surveys

et al. 2014

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“… 63 Patients with mild OSA exhibit altered levels of specific retinoids, carotenoids, and tocopherols, which may be markers and/or mediators of increased susceptibility to vascular disease. 64 Circulating carbon monoxide levels are enable assessment of the clinical severity of OSA. 65 …”

Section: Resultsmentioning

confidence: 99%

Chromatography/Mass Spectrometry-Based Biomarkers in the Field of Obstructive Sleep Apnea

Zheng

Wei³

et al. 2015

Medicine

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Biomarker assessment is based on quantifying several proteins and metabolites. Recent developments in proteomics and metabolomics have enabled detection of these small molecules in biological samples and exploration of the underlying disease mechanisms in obstructive sleep apnea (OSA). This systemic review was performed to identify biomarkers, which were only detected by chromatography and/or mass spectrometry (MS) and to discuss the role of these biomarkers in the field of OSA.We systemically reviewed relevant articles from PubMed and EMBASE referring to proteins and metabolite profiles of biological samples in patients with OSA. The analytical platforms in this review were focused on chromatography and/or MS.In total, 30 studies evaluating biomarkers in patients with OSA using chromatography and/or MS methods were included. Numerous proteins and metabolites, including lipid profiles, adrenergic/dopaminergic biomarkers and derivatives, amino acids, oxidative stress biomarkers, and other micromolecules were identified in patients with OSA.Applying chromatography and/or MS methods to detect biomarkers helps develop an understanding of OSA mechanisms. More proteomic and metabolomic studies are warranted to develop potential diagnostic and clinical monitoring methods for OSA.

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“…Day et al. 47 questioned whether levels of retinoids, carotenoids and tocopherols, some of which have been shown to regulate growth of vascular smooth muscle cells, were altered in otherwise healthy patients with mostly mild OSA. The authors obtained plasma samples from patients with mild OSA without known cardiovascular disease and from control subjects.…”

Section: Sleep Disordered Breathingmentioning

confidence: 99%

“…13 Several mechanisms have been proposed including repeated episodes of hypoxia/reoxygenation (intermittent hypoxia), hypercapnia, inflammation and changes in intrathoracic pressure. Day et al 47 questioned whether levels of retinoids, carotenoids and tocopherols, some of which have been shown to regulate growth of vascular smooth muscle cells, were altered in otherwise healthy patients with mostly mild OSA. The authors obtained plasma samples from patients with mild OSA without known cardiovascular disease and from control subjects.…”

Section: Inflammation and Cardiovascular Risk Cardiovascular Consequmentioning

confidence: 99%

Year in review 2009: Interstitial lung diseases, acute injury, sleep, physiology, imaging and bronchoscopic intervention

et al. 2009

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Key words: acute lung injury, acute respiratory distress syndrome, asthma, endobronchial ultrasound, sleep apnoea. ACUTE LUNG INJURYAcute lung injury (ALI) and ARDS result in significant morbidity and mortality and are major contributors to admissions to intensive care units globally. Consequently, ALI and ARDS were the key themes explored in a number of papers published in Respirology during 2009. Treatment and prevention of acute lung injuryImproved understanding of the pathogenesis of ALI has lead to the development of a number of candidate therapies for the condition. Many basic science observations have, however, yet to be translated into effective treatment for ALI. In general, translational studies have focussed on two potential therapeutic strategies in ALI; the first involves prevention of ALI in these experiments by dosing with the candidate therapy before an insult known to induce lung injury. Such a therapeutic strategy might potentially be used clinically in patients undergoing high-risk surgery, for example, oesophagectomy. The alternative treatment approach has been to try and ameliorate and expedite the resolution of ALI once injury has occurred. Both of these treatment strategies, evaluated in animal models, have been the subjects of papers published in Respirology this year.Rong et al. 1 reported that prophylactic administration of Panax notoginseng saponins (PNS), an extract from the Chinese herb P. notoginseng that has previously been shown to have anti-inflammatory and anti-oxidant actions, alleviates ALI induced by intestinal ischaemia/reperfusion (I/R) injury in rats. The authors studied the effect of PNS in 4 groups of 12 rats; these rats either underwent sham operation and were given placebo or PNS (at a dose of 100 mg/kg) or received 1 h of intestinal ischaemia followed by 3 h of reperfusion and again were treated with either placebo or PNS before reperfusion. ALI was evaluated 3 h after the initiation of reperfusion. PNS-treated animals, in contrast to placebo-treated rats, showed little histological evidence of ALI following (I/R) and showed evidence of reduced inflammatory cell infiltrate in BAL fluid. PNS appeared to act, at least in part, by reducing oxidative stress in the lungs of animals suffering (I/R) injury.Wu et al. 2 by contrast looked at the effect of interleukin (IL)-10 in alleviating ALI by studying rats administered IL-10 following the induction of LPSinduced ALI. The rationale for exploring IL-10 as a potential treatment for ALI was the observation that endogenous IL-10 rises during the resolution phase of lung injury. Furthermore, in vitro, IL-10 reduces neutrophil activation. Interestingly, when administered to LPS-treated rats 12 h post induction of ALI, exogenous IL-10 reduced the severity of the lung injury response. This effect was, however, lost if the administration of IL-10 was delayed until 16 h, suggesting therefore that the therapeutic window of opportunity for treating evolving ALI is a narrow one. Risk factors for lung injury/pulmonary oedema/alveolar hae...

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Plasma levels of retinoids, carotenoids and tocopherols in patients with mild obstructive sleep apnoea

Cited by 13 publications

References 46 publications

Serum Nutritional Biomarkers and Their Associations with Sleep among US Adults in Recent National Surveys

Serum Nutritional Biomarkers and Their Associations with Sleep among US Adults in Recent National Surveys

Chromatography/Mass Spectrometry-Based Biomarkers in the Field of Obstructive Sleep Apnea

Year in review 2009: Interstitial lung diseases, acute injury, sleep, physiology, imaging and bronchoscopic intervention

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