Plasma levels of TIPM-2 in patients with COPD

Tacheva, Tanya; Dimov, Dimo; Georgieva, Yoana; Ilieva, Vanya; Koychev, Atanas; Vlaykova, Tatyana

doi:10.1183/13993003.congress-2016.pa883

Cited by 1 publication

(2 citation statements)

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“…TIMP-2 in COPD subjects was found in the bronchial epithelium and connective tissue, along with apparently large numbers of immunoreactive TIMP-2 endothelial cells [ 146 ]. In another study, Tacheva T. et al showed that plasma levels of TIMP-2 in COPD patients were higher compared to controls with levels correlated with plasma MMP-2 levels [ 147 ]. In addition, the MMP-2/TIMP-2 ratio was elevated in COPD patients and representative of tobacco use [ 147 ].…”

Section: Timps In Copdmentioning

confidence: 99%

“…In another study, Tacheva T. et al showed that plasma levels of TIMP-2 in COPD patients were higher compared to controls with levels correlated with plasma MMP-2 levels [ 147 ]. In addition, the MMP-2/TIMP-2 ratio was elevated in COPD patients and representative of tobacco use [ 147 ]. Although TIMP-2 may be a potential biomarker for COPD, it cannot be correlated with disease severity.…”

Section: Timps In Copdmentioning

confidence: 99%

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Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease

Christopoulou

Papakonstantinou

Stolz

2023

IJMS

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Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the extracellular matrix and the basement membrane. Thus, these enzymes regulate airway remodeling, which is a major pathological feature of chronic obstructive pulmonary disease (COPD). Furthermore, proteolytic destruction in the lungs may lead to loss of elastin and the development of emphysema, which is associated with poor lung function in COPD patients. In this literature review, we describe and appraise evidence from the recent literature regarding the role of different MMPs in COPD, as well as how their activity is regulated by specific tissue inhibitors. Considering the importance of MMPs in COPD pathogenesis, we also discuss MMPs as potential targets for therapeutic intervention in COPD and present evidence from recent clinical trials in this regard.

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Section: Timps In Copdmentioning

confidence: 99%

Section: Timps In Copdmentioning

confidence: 99%