Plasma Lipid Peroxidation and Total Antioxidant Status among Dyslipidaemic and Hypertensive Nigerians with High Risk of Coronary Heart Disease

Ogunro, P S; Wo, Balogun; Idogun, ES; So, Oninla; Po, Elemile; Ak, Eziyi

doi:10.4314/wajm.v28i2.48430

Cited by 9 publications

(7 citation statements)

References 14 publications

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“…A positive correlation observed between MDA and LDL-cholesterol and this result also shown by (Venkata Rao et al 2011) and (Ogunro P. et al 2009) [26,27].…”

Section: Table (2) Characteristics Of the Cardiovascular Diseases Andsupporting

confidence: 73%

Study of Some Markers of Oxidative Stress Statues in Cardiovascular Disease Patients

Muhialdeen

Jawad

Al-Hashemi

2015

JNUS

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The oxidative stress is one of the main cause for cardiovascular diseases and also one of the results of these diseases, its development. The aim of this study was to investigate the relationship between of some oxidative stress markers and cardiovascular diseases. This study involved 84 samples matched ages and sex divided into groups; 28 samples cardiovascular and 28 hypertensive in addition to 28 healthy control group. The following analysis were done: lipid profile, malondialdehyde (MDA), and albumin. The results show there is a significant increase in lipid profile between each group and control group. MDA was significantly higher in patients compared to controls whereas no significant difference was found in albumin between patient and control groups. The increase in MDA which is a product of lipid peroxidation is attributed to destruction in body cell caused by free radicals and resulting oxidative stress. It has been concluded that the assessing the lipid ratios is important even in a normal individual as it is one of the factors for development of cardiovascular diseases and their complications. There is a positive relation between oxidation results from these diseases and their developments.

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“…A positive correlation observed between MDA and LDL-cholesterol and this result also shown by (Venkata Rao et al 2011) and (Ogunro P. et al 2009) [26,27].…”

Section: Table (2) Characteristics Of the Cardiovascular Diseases Andsupporting

confidence: 73%

Study of Some Markers of Oxidative Stress Statues in Cardiovascular Disease Patients

Muhialdeen

Jawad

Al-Hashemi

2015

JNUS

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“…Studies done by Ogunro et al (2009) and Kumar et al (2012) in ischemic heart disease patients revealed a significant decrease in total antioxidant levels and serum antioxidant levels (SOD and CAT), respectively, in comparison with control groups [22, 23]. …”

Section: Discussionmentioning

confidence: 98%

Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease

Punj

Shenoy

Kumari

et al. 2017

International Journal of Dentistry

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Objective To investigate whether there is a relationship between periodontitis and ischemic heart disease by estimation of total antioxidant status in saliva and serum. Materials and Methods A total of 80 samples were collected and divided equally into 4 groups of healthy controls, chronic periodontitis patients, ischemic heart disease patients with periodontitis, and ischemic heart disease patients without periodontitis. Saliva and venous blood samples were collected and analyzed for levels of total antioxidant capacity, superoxide dismutase, glutathione peroxidase, and catalase. Results There were significant (p < 0.05) differences in the mean serum levels of total antioxidant capacity (p < 0.001), superoxide dismutase (p < 0.001), glutathione peroxidase (p < 0.006), and catalase (p < 0.001) within the 4 groups, whereas the mean salivary levels were significant only for glutathione peroxidase (p = 0.001). Both of these serum and salivary antioxidant levels were lower in disease groups of IHD + CP, IHD + H, and CP as compared to healthy controls, with different patterns. Conclusion Antioxidant capacity is significantly hampered in chronic periodontitis and ischemic heart disease patients with or without periodontitis as compared to healthy controls. The salivary and serum antioxidants may not follow the same increase or decrease as a result of increased oxidant stress due to disease.

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“…Atherosclerosis represents a state of heightened oxidative stress characterised by lipid oxidation in the vascular wall 5. Overproduction of ROS under pathophysiological conditions is an important part of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Amlodipine attenuates oxidative stress in the heart and blood of high-cholesterol diet rabbits

Salehi

Mohammadi

Mirzaei

et al. 2012

Cardiovascular Journal of Africa

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IntroductionOxidative stress is a key component of atherosclerosis. It has been suggested that amlodipine inhibits oxidative stress. In this study, we evaluated the effects of amlodipine on the total antioxidant capacity of heart tissue and blood in 36 control and cholesterol-fed male New Zealand white rabbits.MethodsThe rabbits were divided into four groups (n = 9). Group 1 rabbits were fed a regular diet, group 2 were fed a diet with 2% cholesterol, group 3 were fed a regular diet plus 5 mg/kg/day oral amlodipine, and group 4 were fed 2% cholesterol diet plus amlodipine 5 mg/kg/day. At the end of eight weeks, blood samples were drawn and at the same time heart tissue was isolated and frozen in liquid nitrogen. After homogenisation, the solution was centrifuged and the light supernatant was stored at –80˚C. This was used for determination of glutathione peroxidase (GPX), superoxide dismutase (SOD) and (MDA) levels.ResultsEight weeks of amlodipine treatment significantly reduced the levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides in the group on the hypercholesterolaemic diet (p < 0.05). In the blood, the level of thiobarbituric acid-reactive substances increased in the rabbits on the 2% cholesterol diet (group 2) and 2% cholesterol-plusamlodipine diet (group 4) and decreased in the amlodipineonly group (group 3) (p < 0.05). Lipid peroxidation in the heart tissue was similar to that in the blood, except in the amlodipine-only group (group 3). In the blood, the activity of total SOD (tSOD) decreased in the group on the 2% cholesterol diet (group 2) (p < 0.05) and markedly increased in the amlodipine-only (group 3) and 2% cholesterol-plusamlodipine groups (group 4) (p < 0.05).ConclusionAmlodipine decreased oxidative stress in the heart and blood and improved the lipid profile in cholesterolfed rabbits. Therefore, it may be considered a useful tool for the reduction of oxidative stress and improvement of lipid profiles in diseases related to atherosclerosis.

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Plasma Lipid Peroxidation and Total Antioxidant Status among Dyslipidaemic and Hypertensive Nigerians with High Risk of Coronary Heart Disease

Cited by 9 publications

References 14 publications

Study of Some Markers of Oxidative Stress Statues in Cardiovascular Disease Patients

Study of Some Markers of Oxidative Stress Statues in Cardiovascular Disease Patients

Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease

Amlodipine attenuates oxidative stress in the heart and blood of high-cholesterol diet rabbits

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