Plasma Lipidomics of Healthy Japanese Adults Reveals Gender- and Age-Related Differences

Maekawa, Keiko; Okemoto, Kazuo; Ishikawa, Masaki; Tanaka, Rieko; Kumagai, Yoshito; Saito, Yoshiro

doi:10.1016/j.xphs.2017.05.002

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…Cholesterol metabolism is regulated in a sex-specific manner and is associated with distinct risk profiles in men and women [25]. Several investigators have shown that metabolite fingerprints in men and women vary significantly in an age-specific manner [26,27]. Understanding the age and sex interaction within lipid metabolism is important for biomarker identification and will be necessary for precision medicine.…”

Section: Introductionmentioning

confidence: 99%

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

et al. 2020

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Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these diseases calls for better understanding of the age-and sex-related metabolic consequences. High-throughput lipidomic analyses of population-based cohorts offer an opportunity to identify disease-risk-associated biomarkers and to improve our understanding of lipid metabolism and biology at a population level. Here, we comprehensively examined the relationship between lipid classes/subclasses and molecular species with age, sex, and body mass index (BMI). Furthermore, we evaluated sex specificity in the association of the plasma lipidome with age and BMI. Some 747 targeted lipid measures, representing 706 molecular lipid species across 36 classes/subclasses, were measured using a high-performance liquid chromatography coupled mass spectrometer on a total of 10,339 participants from the Australian Diabetes, Obesity and Lifestyle Study (AusDiab), with 563 lipid species being validated externally on 4,207 participants of the Busselton Health Study (BHS). Heat maps were constructed to visualise the relative differences in lipidomic profile between men and women. Multivariable linear regression analyses, including sex-interaction terms, were performed to assess the associations of lipid species with cardiometabolic phenotypes. Associations with age and sex were found for 472 (66.9%) and 583 (82.6%) lipid species, respectively. We further demonstrated that age-associated lipidomic fingerprints differed by sex. Specific classes of ether-phospholipids and lysophospholipids (calculated as the sum composition of the species within the class) were inversely associated with age in men only. In analyses with women alone, higher triacylglycerol and lower lysoalkylphosphatidylcholine species were observed among postmenopausal women compared

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Section: Introductionmentioning

confidence: 99%

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

et al. 2020

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“…We had not hypothesized this change, but several previous studies have related odd-numbered chain fatty acids to estrogens. For example, PC(17:0/20:4) is higher in the plasma from women than in the plasma from men (Maekawa et al 2017). Consistently, tamoxifen also decreases the glycerophospholipids with odd-numbered chain fatty acids (Saito et al 2017).…”

Section: Upregulation Of Glycerolipids With Highly Unsaturated and Odmentioning

confidence: 71%

“…Several previous studies have related the glycerolipids with highly unsaturated fatty acids to estrogens. For example, PC(16:0/20:5), and TG(62:12) are upregulated in the blood plasma from women in comparison with men (Maekawa et al 2017). Highly unsaturated triacylglycerides and PC(40:8) (putatively PC(20:4/20:4) (Balgoma et al 2010a, b)) are upregulated in a model of estrogen-related endometriosis (Dutta et al 2016).…”

Section: Upregulation Of Glycerolipids With Highly Unsaturated and Odmentioning

confidence: 99%

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

et al. 2020

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Introduction The abuse of anabolic androgenic steroids (AASs) is a source of public concern because of their adverse effects. Supratherapeutic doses of AASs are known to be hepatotoxic and regulate the lipoproteins in plasma by modifying the metabolism of lipids in the liver, which is associated with metabolic diseases. However, the effect of AASs on the profile of lipids in plasma is unknown. Objectives To describe the changes in the plasma lipidome exerted by AASs and to discuss these changes in the light of previous research about AASs and de novo lipogenesis in the liver. Methods We treated male Wistar rats with supratherapeutic doses of nandrolone decanoate and testosterone undecanoate. Subsequently, we isolated the blood plasma and performed lipidomics analysis by liquid chromatography-high resolution mass spectrometry. Results Lipid profiling revealed a decrease of sphingolipids and glycerolipids with palmitic, palmitoleic, stearic, and oleic acids. In addition, lipid profiling revealed an increase in free fatty acids and glycerophospholipids with odd-numbered chain fatty acids and/or arachidonic acid. Conclusion The lipid profile presented herein reports the imprint of AASs on the plasma lipidome, which mirrors the downregulation of de novo lipogenesis in the liver. In a broader perspective, this profile will help to understand the influence of androgens on the lipid metabolism in future studies of diseases with dysregulated lipogenesis (e.g. type 2 diabetes, fatty liver disease, and hepatocellular carcinoma).

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“…This is essential to further elucidate the role of the many lipid species in health maintenance. Investigating healthy aged individuals enables the disentanglement of age- from disease-related metabolic changes, which is rarely done as most human ageing studies enrolled patients already suffering from chronic diseases or centenarians of unspecified or poorly characterised health status [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. Moreover, the few studies which claimed to have examined the metabolic profile of healthy individuals did not report on or adjust for physical activity levels [ 47 , 48 , 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolic View on Human Healthspan: A Lipidome-Wide Association Study

et al. 2021

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As ageing is a major risk factor for the development of non-communicable diseases, extending healthspan has become a medical and societal necessity. Precise lipid phenotyping that captures metabolic individuality could support healthspan extension strategies. This study applied ‘omic-scale lipid profiling to characterise sex-specific age-related differences in the serum lipidome composition of healthy humans. A subset of the COmPLETE-Health study, composed of 73 young (25.2 ± 2.6 years, 43% female) and 77 aged (73.5 ± 2.3 years, 48% female) clinically healthy individuals, was investigated, using an untargeted liquid chromatography high-resolution mass spectrometry approach. Compared to their younger counterparts, aged females and males exhibited significant higher levels in 138 and 107 lipid species representing 15 and 13 distinct subclasses, respectively. Percentage of difference ranged from 5.8% to 61.7% (females) and from 5.3% to 46.0% (males), with sphingolipid and glycerophophospholipid species displaying the greatest amplitudes. Remarkably, specific sphingolipid and glycerophospholipid species, previously described as cardiometabolically favourable, were found elevated in aged individuals. Furthermore, specific ether-glycerophospholipid and lyso-glycerophosphocholine species displayed higher levels in aged females only, revealing a more favourable lipidome evolution in females. Altogether, age determined the circulating lipidome composition, while lipid species analysis revealed additional findings that were not observed at the subclass level.

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Plasma Lipidomics of Healthy Japanese Adults Reveals Gender- and Age-Related Differences

Cited by 8 publications

References 17 publications

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Metabolic View on Human Healthspan: A Lipidome-Wide Association Study

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