2013
DOI: 10.2337/dc13-0451
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Plasma Lipopolysaccharide Is Closely Associated With Glycemic Control and Abdominal Obesity

Abstract: OBJECTIVEIt is of vital importance to elucidate the triggering factors of obesity and type 2 diabetes to improve patient care. Bariatric surgery has been shown to prevent and even cure diabetes, but the mechanism is unknown. Elevated levels of lipopolysaccharide (LPS) predict incident diabetes, but the sources of LPS are not clarified. The objective of the current study was to evaluate the potential impact of plasma LPS on abdominal obesity and glycemic control in subjects undergoing bariatric surgery.RESEARCH… Show more

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Cited by 177 publications
(161 citation statements)
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“…Since subjects from the present study had similar energy and macronutrient intakes, it is possible that higher LPS concentrations influence the accumulation of central fat and insulin resistance. A current hypothesis holds that translocation of gut-derived molecules to adipose tissue localized in close proximity to the gut, such as mesenteric fat, would trigger macrophage infiltration and inflammation, which, in turn, would stimulate expansion of this visceral depot [12,35]. The downstream signaling of the insulin receptor can be impaired by inflammatory signals, which can be directly induced by LPS stimulation [5,6].…”
Section: Discussionmentioning
confidence: 96%
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“…Since subjects from the present study had similar energy and macronutrient intakes, it is possible that higher LPS concentrations influence the accumulation of central fat and insulin resistance. A current hypothesis holds that translocation of gut-derived molecules to adipose tissue localized in close proximity to the gut, such as mesenteric fat, would trigger macrophage infiltration and inflammation, which, in turn, would stimulate expansion of this visceral depot [12,35]. The downstream signaling of the insulin receptor can be impaired by inflammatory signals, which can be directly induced by LPS stimulation [5,6].…”
Section: Discussionmentioning
confidence: 96%
“…Trøseid et al [12] presented evidences that plasma LPS concentrations were more strongly correlated with intra-abdominal fat than with subcutaneous fat volumes. The mechanisms underlying this association are unclear.…”
Section: Discussionmentioning
confidence: 98%
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