Plasma lysolecithinase activity in pregnancy

Portman, Oscar W.; Soltys, Patricia A.; Alexander, Manfred

doi:10.1016/0005-2744(68)90052-1

Cited by 14 publications

(2 citation statements)

References 12 publications

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“…Lysophosphatidylcholin wird nach seiner Entstehung durch eine im Plasma v o r k o m m e n d e Lysophospholipase weiter abgebaut [13,52,60,61]. Lysophosphatidylcholin wird nach seiner Entstehung durch eine im Plasma v o r k o m m e n d e Lysophospholipase weiter abgebaut [13,52,60,61].…”

Section: Abhiingigkeit Der Lysophosphatidylcholinkonzentration Iunclassified

“…Es wird durch die Lecithin-Cholesterin-Acyltransferase (LCAT), die in der Leber synthetisiert wird [25,48], durch Abspaltung der Fetts~iure an der ]?-Position des lipoproteingebundenen Phosphatidylcholin (Lecithin) gebildet [25] und an Albumin gebunden [26,34,62,69]. Der weitere Abbau zu Glycerophosphorylcholin erfolgt ebenfalls enzymatisch [13,52], m6glicherweise durch zwei verschiedene Lysophospholipasen [61].…”

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�ber die Bedeutung der W�rmestabilisierung einer beschleunigten Blutk�rperchensenkung in der klinischen Diagnostik

Adlkofer

Armbrecht

et al. 1978

Klin Wochenschr

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Heat-induced inhibition of erythrocyte sedimentation (HIES) was examined in 158 cases. HIES is significantly lower in patients with a liver cell damage isolated or due to metastases of a neoplastic process in comparison to that in patients suffering from inflammation or malign tumor not involving the liver. Generally, HIES depends upon the concentration of lysophosphatidyl choline (lysolecithin) which is set free in plasma by lecithin-cholesterol-acyltransferase (LCAT) during incubation. In patients with lever cell damage, LCAT is diminished. HIES is being influenced by several factors: Lysophosphatidyl choline is bound to albumin, and this prevents its reaction on the erythrocyte surface. Lysophospholipase reduces the concentration of lysophosphatidyl choline in the plasma by splitting off its fatty acid in the alpha-position. Specific serum proteins, the so-called agglomerines, which are responsible for the acceleration of erythrocyte sedimentation, are counteracting the HIES. The concentration of albumin and agglomerines in plasma and the activity of lysophospholipase are subject to physiologically and pathologically caused deviations. Thereby, HIES is being influenced individually at varying degrees. This makes it difficult to estimate the LCAT activity which represents the principal cause of HIES. As a consequence, HIES seems not to be suitable for clinical diagnostics.

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Section: Abhiingigkeit Der Lysophosphatidylcholinkonzentration Iunclassified

unclassified

�ber die Bedeutung der W�rmestabilisierung einer beschleunigten Blutk�rperchensenkung in der klinischen Diagnostik

Adlkofer

Armbrecht

et al. 1978

Klin Wochenschr

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The fatty acid composition of the main phospholipid fractions of the rumen and abomasum tissues of foetal and adult sheep

Body¹,

Shorland²

1974

J Sci Food Agric

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The fatty acid composition has been determined on phosphatidyl choline, phosphatidyl ethanolamine and sphingomyelin fractions earlier isolated from the rumen and abomasum tissues of foetal and of adult Romney sheep.The major proportion of polyunsaturated fatty acids was found in the phosphatidyl ethanolamine (17 to 43 %) fraction and this was reduced in the phosphatidyl choline (7 to 25 %) and sphingomyelin (1 to 4 %) fractions. These features are in keeping with the results for mammalian tissues generally. The phosphatidyl ethanolamine fractions were further characterised by the low content of palmitic acid (4 %) compared with 25 to 30% in the phosphatidyl choline fractions and 29 to 52 % in the sphingomyelin fractions and by the occurrence of cyclopropane fatty acids. Consistent with the findings of other workers on mammalian tissues, the sphingomyelin fractions contained a relatively high content (16 to 27%) of higher maturated fatty acids including 22: 0,23 : 0,24: 0 and 25 : 0 and of tetracos-14-enoic (24: 1 w9) acid (5 to 16%). The total amounts of acids above Czo tended to vary inversely with the levels of palmitic acid whereas the levels of stearic acid were relatively constant at 13 to 17%. Changes in fatty acid composition with age were generally not marked but the tissues of the foetus were distinguished from those of the adult by their substantial amount of eicosa-5,8,1l-trienoic (20: 3 09) acid together with relatively low contents of linoleic (18: 2 w6) and linolenic (1 8: 3 w3) acids and to a lesser extent by reduced level of acids of the w3 series. This was particularly reflected by the ratios of w6/w3 Czo + Cz2 acids in the phosphatidyl ethanolamine fractions, the values for the foetal rumen and abomasum tissues being 1.03 and 1.07, respectively, compared with corresponding values of 0.78 and 0.72 found in adult sheep.The results are consistent with a requirement for Czo and C,, polyunsaturated acids of the w3 and w6 series and some penetration of maternal fatty acids through the placenta. The resemblance between the fatty acid make-up and composition of foetal and maternal phospholipids suggests the possibility of transference of intact or lyso-phospholipids from the mother to the foetus through the placenta. However, such a possibility is counter-indicated by consideration of previous work using labelled intermediates and by the mechanism of conversion of linoleic and linolenic acids requiring their CoA derivatives in the formation of the corresponding polyunsaturated Cz0 4 Czz acids. Nevertheless, the sharp cut-off of exogenous maternal fatty acids from the foetal triglycerides and their inclusion in the foetal phospholipids are not readily explainable.

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