Plasma metals and serum bilirubin levels in workers from manganese-exposed workers healthy cohort (MEWHC)

Ge, Xiaoting; Liu, Zhenfang; Hou, Qingzhi; Huang, Lulu; Zhou, Yanting; Li, Defu; Huang, Sifang; Luo, Xiaoyu; Lv, Yingnan; Li, Longman; Cheng, Hong; Chen, Xiang; Zan, Gaohui; Tan, Yanli; Liu, Chaoqun; Zou, Yue; Yang, Xiaobo

doi:10.1016/j.envpol.2019.113683

Cited by 28 publications

(10 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liver is a major target organ of Mn exposures [ 4 , 14 , 35 , 40 ]. Chronic liver diseases further contribute to excessive accumulation of Mn in the brain leading to Mn hepatic encephalopathy [ 17 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Occupational exposures to Mn occur primarily through the steel industry, smelters and welding [ 4 , 10 , 15 , 24 ]. Overexposure to Mn is known to cause clinical syndromes, including the neurologic disorder like Parkinsonism, dystonia, neuropsychiatric symptoms, motor activity impairment, subclinical liver dysfunction and increased serum bilirubin levels [ 14 , 27 , 34 , 40 ]. Mn neurotoxicity is known to specifically damage the basal ganglia in humans [ 1 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

“…Manganism and hepatic encephalopathy are the most common pathologies from Mn exposures [ 35 ]. Liver dysfunction and injury are frequently observed in Mn exposed workers [ 4 , 14 , 35 , 40 ], and Manganism patients are often associated with liver diseases [ 23 ]. Chronic liver diseases can result in an excessive accumulation of Mn in brain with ensuing signs and symptoms clinically called Mn hepatic encephalopathy [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats

et al. 2020

View full text Add to dashboard Cite

Subacute exposure to manganese (Mn) produced Parkinson's disease-like syndrome called Manganism. Chronic onset and progression are characteristics of Manganism, therefore, this study aimed to examine Mn toxicity following chronic exposures. Male Sprague-Dawley rats were injected Mn 2+ 1 and 5 mg/kg, every 10 days for 150 days (15 injections). Animal body weight and behavioral activities were recorded. At the end of experiments, the brain and liver were collected for morphological and molecular analysis. Chronic Mn exposure did not affect animal body weight gain, but the high dose of Mn treatment caused 20% mortality after 140 days of administration. Motor activity deficits were observed in a dose-dependent manner at 148 days of Mn administration. Immunofluorescence double staining of substantia nigra pars compacta (SNpc) revealed the activation of microglia and loss of dopaminergic neurons. The chronic neuroinflammation mediators TNFα, inflammasome Nlrp3, Fc fragment of IgG receptor IIb, and formyl peptide receptor-1 were increased, implicating chronic Mn-induced neuroinflammation. Chronic Mn exposure also produced liver injury, as evidenced by hepatocyte degeneration with pink, condensed nuclei, indicative of apoptotic lesions. The inflammatory cytokines TNFα, IL-1β, and IL-6 were increased, alone with stress-related genes heme oxygenase-1, NAD(P)H:quinone oxidoreductase-1 and metallothionein. Hepatic transporters, such as multidrug resistant proteins (Abcc1, Abcc2, and Abcc3) and solute carrier family proteins (Slc30a1, Slc39a8 and Slc39a14) were increased in attempt to eliminate Mn from the liver. In summary, chronic Mn exposure produced neuroinflammation and dopaminergic neuron loss in the brain, but also produced inflammation to the liver, with upregulation of hepatic transporters.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…We used an inductively coupled plasma mass spectrometry (ICP-MS, Perkin Elmer NexION 350xX, USA) to measure the serum metal concentrations of FAMHES and plasma metal concentrations of MEWHC, respectively. Our previous research also introduced the corresponding methods 89 , 92 . Specifically, each serum/plasma sample was diluted 20 times by using acidic solution containing 0.01% Triton TM X-100, 0.5% n-butyl alcohol and 1% nitric acid.…”

Section: Methodsmentioning

confidence: 99%

Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans

Yang

Feng

et al. 2022

Commun Biol

Self Cite

View full text Add to dashboard Cite

Metal elements are present in the human body, and their levels in the blood have important impacts on health. In this study, 2488 Chinese individuals were included in a genome-wide association study of 21 serum metal levels, with approximately 179,000 East Asian individuals in a bidirectional two-sample Mendelian randomization (MR) analysis, and 628,000 Europeans in a two-sample MR analysis. We identified two single nucleotide polymorphisms (SNPs) rs35691438 and rs671 that were significantly associated with serum copper levels (SCLs). The bidirectional two-sample MR analysis in the East Asian population showed that gamma-glutamyl transpeptidase levels have a causal effect on SCLs. SCLs have causal effects on six outcomes, namely risks of esophageal varix, glaucoma, sleep apnea syndrome, and systemic lupus erythematosus, white blood cell count, and usage of drugs affecting bone structure and mineralization. The two-sample MR analyses in the European population showed causal effects of erythrocyte copper levels on risks of carpal tunnel syndrome and compression fracture. Our results provide original insights into the causal relationship between blood metal levels and multiple human phenotypes.

show abstract

“…Current toxicological or epidemiological studies mainly focus on the single‐metal exposure effects, which have some weaknesses, such as the inability to consider the co‐exposure of pollutants and the complex interaction of metals in the body (Ge et al, 2020). Therefore, it is quite essential to figure out combined effects of multiple metals on health.…”

Section: Introductionmentioning

confidence: 99%

Heavy metals exposure is associated with early liver dysfunction among rural residents aged 40–75 years in southwest China

Yang

Tian

et al. 2021

J of Applied Toxicology

View full text Add to dashboard Cite

Heavy metals exposure has been associated with liver dysfunction in recent reports, while the hepatoxicity of lead (Pb) and cadmium (Cd) has been well established.However, the combined effects of multi-metal in real-world scenario on liver dysfunction are still unclear. This cross-sectional study examined associations between 10 biomarkers of early liver injury and multiple heavy metals levels. The levels of heavy metals/metalloid (magnesium [Mg], calcium [Ca], iron [Fe], zinc [Zn], arsenic [As], Cd, copper [Cu], and Pb) were measured in blood and urinary sample collected from 725 participants in a Cd-polluted area and an unpolluted area in southwest China. The early liver dysfunction biomarkers included the liver enzymes (ALT, ALP, AST, and GGT), proteins (TP, ALB, and GLO), and bilirubin (TBIL, DBIL, and IBIL).Confounder-adjusted beta coefficients were determined using multiple linear regression model analysis for the group-classified and gender-classified samples. Our results showed that blood Fe, Cd, and Cu levels were found to be positively related to elevated ALT levels and blood Cu was positively associated with AST levels in the Cd-polluted area, while the highest blood Zn quartile in the polluted area and blood Mg quartile in the unpolluted area were associated with lower ALT levels. Our finding implies that industrial pollution results in heavy metals of Cd and Pb exposure and effects of Fe, Cd, Cu, and Pb in the Cd-polluted area may be the main contributors to increase the risk of liver dysfunction while Zn in the Cd-polluted area and Mg in the unpolluted area may be the protective factors.

show abstract

Plasma metals and serum bilirubin levels in workers from manganese-exposed workers healthy cohort (MEWHC)

Cited by 28 publications

References 52 publications

Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats

Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats

Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans

Heavy metals exposure is associated with early liver dysfunction among rural residents aged 40–75 years in southwest China

Contact Info

Product

Resources

About