Plasma neutrophil gelatinase-associated lipocalin as a predictive biomarker for the detection of acute kidney injury in adult poisoning

Abstract

Plasma NGAL may serve as a good predictor of AKI in cases of adult poisoning.

Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth

“…NGALs role in innate immunity, inflammation and its increased production during epithelial damage has led to extensive investigation of NGAL proteoforms in urine as biomarkers of acute kidney injury. 26,27 The pattern of NGAL immunoreactivity has been proposed as marker to distinguish among different pathologic processes leading to kidney injury. Interestingly, the NGAL band detected at ~50 kDa under non-reducing conditions which most likely represents the dimeric form, has been previously identified in urine of patients with urinary tract infections and is thought to be preferentially secreted by activated neutrophils.…”

Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

“…4,24,25,26 Similar efforts are underway in veterinary medicine and show great promise. [28][29][30][31][32][33][34][35][36] (See also, Yerramilli in this issue) An AKI biomarker should be detectable in urine and/or plasma such that it can be assessed routinely and serve as an indicator of kidney function or dysfunction or response to injury. The ideal marker should reflect kidney specific events, be unique and specific to the kidney, and reflect very early and potentially sustained phases of the pathogenesis and repair processes.…”

Neutrophil gelatinase-associated lipocalin for early diagnosis of acute kidney injury in patients with acute decompensated heart failure

“…NGAL -гликопротеин, который высвобождается из клеток канальцев во время воспаления или травмы [6][7][8][9]. Первоначально NGAL был обнаружен как важ ный компонент антимикробного врожденного имму нитета [10,11] и признан белком острой фазы [12,13].…”

“…В ряде исследований показано, что NGAL образует ся в почках после ишемического или нефротоксического повреждения [7,8]. NGAL повышается в крови пациен тов с ОПП в течение 2 ч [18,19] и достигает пика при мерно через 6 ч после ОПП.…”