Plasma Noradrenaline and Clinical Psychopathology in Schizophrenia

Dajas, Federico; Barbeito, Luis; Martinez-Pesquera, G.; Lista, Alvaro; Puppo, D.; Puppo-Touriz, H.

doi:10.1159/000117988

Cited by 21 publications

(9 citation statements)

References 9 publications

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“…In particular, biochemical data indicate that a dysfunction of the N A system is as sociated with acute psychosis [1][2][3][4][5][6] or with paranoia [7,8] in schizophrenia. Most NA in the brain is ulti mately metabolized to 3-methoxy-4-hydroxyphenylglycol (M H PG).…”

Section: Introductionmentioning

confidence: 99%

Plasma Free 3-Methoxy-4- Hydroxyphenylglycol in Acute Schizophrenics before and after Treatment

Kaneko

Honda²,

Kanno³

et al. 1992

Neuropsychobiology

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Plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG) was measured in 19 patients with acute schizophrenia before and after neuroleptic therapy. Plasma antinoradrenergic activity (pANA) of the neuroleptics used was measured after treatment. Before treatment, pMHPG was higher in the patients than in 20 normal controls. There was a positive correlation between pMHPG level and the global severity of positive symptoms. After neuroleptic therapy, pMHPG was reduced, and there was a significant correlation between the decline in pMHPG and the improvement in positive symptom score. The decline in pMHPG was also correlated with pANA. These results suggest that there is a dysfunction of the noradrenergic system in the brains of some acute schizophrenics with mainly positive symptoms, and that this dysfunction may be improved, along with positive symptom score, after neuroleptic therapy.

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Section: Introductionmentioning

confidence: 99%

Plasma Free 3-Methoxy-4- Hydroxyphenylglycol in Acute Schizophrenics before and after Treatment

Kaneko

Honda²,

Kanno³

et al. 1992

Neuropsychobiology

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“…Present results must be considered when analyzing similar changes appearing in other disorders like depression or schizophrenia (Koslow et al, 1983;Dajas et al, 1983;Barbeito et aL, 1984). Even though the noradrenergic overactivity found in these disorders is higher than in anxious patients, the role of anxiety cannot be discarded.…”

Section: Resultsmentioning

confidence: 70%

Urinary norepinephrine excretion in panic and phobic disorders

Dajas

Nin

Barbeito

1986

J. Neural Transmission

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Morning urinary norepinephrine (NE) was assessed in 36 patients suffering from panic and phobic disorders according to DSM III. Urinary NE excretion was significantly higher in this group than in a normal control one. Phobic patients excreted lower levels of NE than panic ones. No significant association was found between urinary NE levels and anxiety scores according to Zung's Anxiety Status Inventory or Wittenborn Psychiatric Rating Scale. The NE increase is interpreted as reflecting a sympathetic nervous system hyperactivity in anxiety. A concomitant effect upon NE metabolism of benzodiazepine withdrawal cannot be discarded since the group of patients previously medicated showed the highest NE excretion.

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“…In the context of perceptual inference, sensory areas of the cerebral cortex may be regarded as comparators in a closed feedback loop, similar to the better known reflexes in the sensorimotor system and akin to a servomechanism, as proposed by some current models of statistical inference and by statistical decision theory. Aggelopoulos and Edgley (1995), Briand et al (2007), Cisek and Kalaska (2005), Collerton et al (2005), Corbetta et al (2008), Dajas et al (1983), Dominey and Arbib (1992), Dzirasa et al (2006), Fienberg (2006), Fujita et al (1992), Gross et al (1972), Hohwy et al (2008), Ito et al (1994), Itti and Koch (2000), Iwabuchi (1998), James (1890, Knill and Richards (1996), Kobatake and Tanaka (1994), von der Malsburg and Schneider (1986), Nielsen et al (2006), Renshaw (1946), Treisman (1985), Treisman (1986) and Zinke et al (2006).…”

Section: Resultsmentioning

confidence: 99%

Perceptual inference

Aggelopoulos

2015

Neuroscience & Biobehavioral Reviews

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Perceptual inference refers to the ability to infer sensory stimuli from predictions that result from internal neural representations built through prior experience. Methods of Bayesian statistical inference and decision theory model cognition adequately by using error sensing either in guiding action or in "generative" models that predict the sensory information. In this framework, perception can be seen as a process qualitatively distinct from sensation, a process of information evaluation using previously acquired and stored representations (memories) that is guided by sensory feedback. The stored representations can be utilised as internal models of sensory stimuli enabling long term associations, for example in operant conditioning. Evidence for perceptual inference is contributed by such phenomena as the cortical co-localisation of object perception with object memory, the response invariance in the responses of some neurons to variations in the stimulus, as well as from situations in which perception can be dissociated from sensation. In the context of perceptual inference, sensory areas of the cerebral cortex that have been facilitated by a priming signal may be regarded as comparators in a closed feedback loop, similar to the better known motor reflexes in the sensorimotor system. The adult cerebral cortex can be regarded as similar to a servomechanism, in using sensory feedback to correct internal models, producing predictions of the outside world on the basis of past experience.

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Plasma Noradrenaline and Clinical Psychopathology in Schizophrenia

Cited by 21 publications

References 9 publications

Plasma Free 3-Methoxy-4- Hydroxyphenylglycol in Acute Schizophrenics before and after Treatment

Plasma Free 3-Methoxy-4- Hydroxyphenylglycol in Acute Schizophrenics before and after Treatment

Urinary norepinephrine excretion in panic and phobic disorders

Perceptual inference

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